Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nichole K. Escalante"'
Autor:
Kenny L. Chan, Theresa H. Tam, Parastoo Boroumand, David Prescott, Sheila R. Costford, Nichole K. Escalante, Noah Fine, YuShan Tu, Susan J. Robertson, Dilshaayee Prabaharan, Zhi Liu, Philip J. Bilan, Michael W. Salter, Michael Glogauer, Stephen E. Girardin, Dana J. Philpott, Amira Klip
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2415-2426 (2017)
Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets that leads to type 2 diabetes. It is hypothesized that lipids and gut bacterial compounds in particular contribute to metabolic inflammation by activating t
Externí odkaz:
https://doaj.org/article/d27abc9d34b1483fb1014debca2d6c7b
Autor:
Maya C. Poffenberger, Jennifer L. Bishop, Ryan J. Blackler, Kevin G. Haworth, Steven Booth, Shalla Hanson, Jeff R. Proctor, I-Ting Shao, Nichole K. Escalante, Dayananda Siddappa, Joel Smith, Gursev Anmole, Saki Konomura, Nicholas A. Dawson, Sifa Arrafi, Desmond Lau, Gerry Rowse, Rupert H. Davies, Thomas Spreter von Kreudenstein
Publikováno v:
Cancer Research. 83:2935-2935
IL-12 is a pleiotropic cytokine that potently stimulates anti-tumor cytotoxic T and NK cell mediated immunity. Recombinant IL-12 reduces tumor growth in multiple mouse models, but its therapeutic application has been limited by severe toxicities. Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce2847d4ba0b7753f41e7b03785e454
https://doi.org/10.1158/1538-7445.am2023-2935
https://doi.org/10.1158/1538-7445.am2023-2935
Autor:
Lisa Newhook, Purva P. Bhojane, Peter W. Repenning, Diego Perez Escanda, Nichole K. Escalante, Patricia Zwierzchowski, Alec Robinson, Lauren Clifford, Harsh Pratap, David N. Douda, Chayne L. Piscitelli, Nicole J. Afacan, Thomas Spreter von Kreudenstein, Nina E. Weisser
Publikováno v:
Cancer Research. 83:5121-5121
Bispecific T cell engager (TCE) therapies have exhibited clinical utility against hematological cancers, but limited success in solid tumors. Treatment of solid tumors has additional challenges - including immunosuppressive environments and low T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce0b30ab0d4c4263c81cb50f1010c356
https://doi.org/10.1158/1538-7445.am2023-5121
https://doi.org/10.1158/1538-7445.am2023-5121
Autor:
Anuradha Surendra, Nichole K. Escalante, Susan J. Robertson, Stephanie Fieve, Qiaochu Lin, David S. Guttman, Dana J. Philpott, Catherine J. Streutker, Cynthia X. Guo, Thierry Mallevaey, Thirumahal Selvanantham
Publikováno v:
The Journal of Immunology. 197:4464-4472
NKT cells are unconventional T cells that respond to self and microbe-derived lipid and glycolipid Ags presented by the CD1d molecule. Invariant NKT (iNKT) cells influence immune responses in numerous diseases. Although only a few studies have examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e24c6f6a59e6fd0c83d9e2469fc94ce
https://doi.org/10.4049/jimmunol.1601410
https://doi.org/10.4049/jimmunol.1601410
Autor:
Jeffrey Downey, Leandro Silva da Costa, Armin Farahvash, Stephen E. Girardin, Aaron Trotman-Grant, Ryan G. Gaudet, Maziar Divangahi, Leticia A.M. Carneiro, Damien Arnoult, Farshad C. Azimi, Jeffrey E. Lee, Charles C. Y. Lau, Raphael Molinaro, Nichole K. Escalante, Dave Prescott, Scott D. Gray-Owen, Elise Sofie Hovingh, J J Chen, Ahmed Outlioua, Dana J. Philpott, Jessica Tsalikis, Rob van Dalen, Mena Abdel-Nour
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2019, 365 (6448), pp.eaaw4144. ⟨10.1126/science.aaw4144⟩
Science, American Association for the Advancement of Science, 2019, 365 (6448), pp.eaaw4144. ⟨10.1126/science.aaw4144⟩
Linking protein misfolding and innate immunity Multiple innate immune sensors undergo rapid assembly into large complexes known as signalosomes. This is an essential step during cellular responses to microbes and danger signals. How this process is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3b5e2219bef4b686ba89411fd9f65b
https://doi.org/10.1126/science.aaw4144
https://doi.org/10.1126/science.aaw4144
Autor:
Stephen E. Girardin, David Prescott, Catherine J. Streutker, Nichole K. Escalante, Paul Lemire, Arthur Mortha, Dana J. Philpott, Thierry Mallevaey, Mayra Cruz Tleugabulova
Publikováno v:
The Journal of Experimental Medicine
Escalante et al. show that a highly prevalent mouse intestinal protozoa, Tritrichomonas muris, was found to be a confounding factor in murine colitis. Mice infected with this parasite had elevated baseline levels of Th1 cytokines and developed exacer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757efe0383dfa1eb278d65f88b336c32
http://europepmc.org/articles/PMC5154950
http://europepmc.org/articles/PMC5154950
Autor:
Steven J. Berardinelli, Naotaka Tsutsumi, Jacob Piehler, Leon Su, Timothy M. Horton, K. Christopher Garcia, Nichole K. Escalante, Edgar G. Engleman, Kevin Jude, Robert S. Haltiwanger, Junel Sotolongo Bellón, Juan L. Mendoza
Publikováno v:
Nature. 567(7746)
The cytokine interferon-γ (IFNγ) is a central coordinator of innate and adaptive immunity, but its highly pleiotropic actions have diminished its prospects for use as an immunotherapeutic agent. Here, we took a structure-based approach to decouplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d49b7e4391c71ba11206a09513f7c8
https://pubmed.ncbi.nlm.nih.gov/31131497
https://pubmed.ncbi.nlm.nih.gov/31131497
Autor:
Thierry Mallevaey, Thirumahal Selvanantham, Stephanie Fieve, Dana J. Philpott, Nichole K. Escalante, Stephen E. Girardin, Mayra Cruz Tleugabulova
Publikováno v:
The Journal of Immunology. 191:5646-5654
Invariant NKT (iNKT) cells act at the crossroad between innate and adaptive immunity and are important players in the defense against microbial pathogens. iNKT cells can detect pathogens that trigger innate receptors (e.g., TLRs, Rig-I, Dectin-1) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c84dc8cb510e8fcbde2fdfc53792f1
https://doi.org/10.4049/jimmunol.1301412
https://doi.org/10.4049/jimmunol.1301412
Autor:
June Ereño-Orbea, Jean-Philippe Julien, Paul B. Savage, Shenglou Deng, Nichole K. Escalante, Mayra Cruz Tleugabulova, Stephanie Fieve, Thierry Mallevaey
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(10)
Invariant NKT (iNKT) cells develop and differentiate in the thymus, segregating into iNKT1/2/17 subsets akin to Th1/2/17 classical CD4+ T cells; however, iNKT TCRs recognize Ags in a fundamentally different way. How the biophysical parameters of iNKT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603802f31b4dd5d5dfd4241df6b24e2e
https://pubmed.ncbi.nlm.nih.gov/27798168
https://pubmed.ncbi.nlm.nih.gov/27798168
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1177-1184
Objective— CD155 is a cell surface protein that has recently been described to exert immune regulatory functions. We have characterized the expression of CD155 on human vascular endothelial cells (ECs) and examined its role in the regulation of T-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430a7b5679ee78331abb882ae5c1a2c5
https://doi.org/10.1161/atvbaha.111.224162
https://doi.org/10.1161/atvbaha.111.224162