Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nichole Giles"'
Autor:
Nicholas Ariotti, James Rae, Nichole Giles, Nick Martel, Emma Sierecki, Yann Gambin, Thomas E Hall, Robert G Parton
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2005473 (2018)
We describe the development and application of a suite of modular tools for high-resolution detection of proteins and intracellular protein complexes by electron microscopy (EM). Conditionally stable GFP- and mCherry-binding nanobodies (termed csGBP
Externí odkaz:
https://doaj.org/article/3a04581909f74553b2a9b43340be88b5
Autor:
Sally Martin, Andreas Papadopulos, Vanesa M. Tomatis, Emma Sierecki, Nancy T. Malintan, Rachel S. Gormal, Nichole Giles, Wayne A. Johnston, Kirill Alexandrov, Yann Gambin, Brett M. Collins, Frederic A. Meunier
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 206-218 (2014)
Summary: Munc18-1 is a critical component of the core machinery controlling neuroexocytosis. Recently, mutations in Munc18-1 leading to the development of early infantile epileptic encephalopathy have been discovered. However, which degradative pathw
Externí odkaz:
https://doaj.org/article/2e7ca60d308c4c5082ebb337142d727b
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 655 (2016)
Protein self-association is a key feature that can modulate the physiological role of proteins or lead to deleterious effects when uncontrolled. Protein oligomerization is a simple way to modify the activity of a protein, as the modulation of binding
Externí odkaz:
https://doaj.org/article/dd98ffb12f8342989b28538ed46cafc6
Autor:
Nichole Giles, Mathias Francois, Dominic J. B. Hunter, Paulina Rudolffi Soto, Alex Jade McCann, Mehdi Moustaqil, Emma Sierecki, Akshay Bhumkar, Frank Fontaine, Timothy L. Bailey, Yann Gambin, Jeroen Overman
Publikováno v:
Nucleic Acids Research
During embryogenesis, vascular development relies on a handful of transcription factors that instruct cell fate in a distinct sub-population of the endothelium (1). The SOXF proteins that comprise SOX7, 17 and 18, are molecular switches modulating ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eafb53ed3251ef8e2ab735213c3249b
https://doi.org/10.1093/nar/gky897
https://doi.org/10.1093/nar/gky897
Autor:
Nichole Giles, Rachel S. Gormal, Frederic A. Meunier, Jürgen Götz, Isabel C. Morrow, Ye Jin Chai, Di Xia, Robert G. Parton, Brett M. Collins, Emma Sierecki, Vanesa M. Tomatis, Yann Gambin
Publikováno v:
The Journal of Cell Biology
Munc18-1 heterozygous mutations are associated with developmental diseases, including early infantile epileptic encephalopathy (EIEE). Chai et al. report that Munc18-1 acts as a chaperone for α-synuclein and controls its aggregative propensity. Munc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00479ea7e1c63bc3d6b60b39fe24f659
http://europepmc.org/articles/PMC5021092
http://europepmc.org/articles/PMC5021092
Autor:
Emma Suwanun Singer, Marc R. Wilkins, Nichole Giles, Veronica Mendoza-Reinoso, Annemiek Beverdam, Susan M. Corley, John E.A. Common
Publikováno v:
Cell Death and Disease, Vol 9, Iss 11, Pp 1-13 (2018)
Cell Death & Disease
Cell Death & Disease
Yes-associated protein (YAP) is a mechanosensor protein and a downstream effector of the Hippo kinase pathway, which controls organ growth, cell proliferation, survival, maintenance and regeneration. Unphosphorylated YAP translocates to the nucleus w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc9b43be0848111632884f53f7468c6
https://doi.org/10.1038/s41419-018-1141-5
https://doi.org/10.1038/s41419-018-1141-5
Autor:
Janina, Steinbeck, Ian L, Ross, Rosalba, Rothnagel, Philipp, Gäbelein, Stefan, Schulze, Nichole, Giles, Rubbiya, Ali, Rohan, Drysdale, Emma, Sierecki, Yann, Gambin, Henning, Stahlberg, Yuichiro, Takahashi, Michael, Hippler, Ben, Hankamer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(41)
Photosynthetic linear electron flow (LEF) produces ATP and NADPH, while cyclic electron flow (CEF) exclusively drives photophosphorylation to supply extra ATP. The fine-tuning of linear and cyclic electron transport levels allows photosynthetic organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e138d44ef7c34cf20dc59d0a88651a2
https://pubmed.ncbi.nlm.nih.gov/30254175
https://pubmed.ncbi.nlm.nih.gov/30254175
Autor:
Nick Martel, Emma Sierecki, Yann Gambin, Nicholas Ariotti, Nichole Giles, Thomas E. Hall, James Rae, Robert G. Parton
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2005473 (2018)
PLoS Biology
PLoS Biology
We describe the development and application of a suite of modular tools for high-resolution detection of proteins and intracellular protein complexes by electron microscopy (EM). Conditionally stable GFP- and mCherry-binding nanobodies (termed csGBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c1b0b9c6e33aec9853665b42912039
https://doaj.org/article/3a04581909f74553b2a9b43340be88b5
https://doaj.org/article/3a04581909f74553b2a9b43340be88b5
Autor:
Emma Sierecki, Yann Gambin, Nichole Giles, Dominic J. B. Hunter, Mark E. Polinkovsky, Ailis O'Carroll
Publikováno v:
Journal of molecular biology. 430(4)
Single-molecule fluorescence has the unique ability to quantify small oligomers and track conformational changes at a single-protein level. Here we tackled one of the most extreme protein behaviors, found recently in an inflammation pathway. Upon dan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3f7fdf2097229051e0eea60634f47c
https://pubmed.ncbi.nlm.nih.gov/29526304
https://pubmed.ncbi.nlm.nih.gov/29526304
Autor:
Nichole Giles, Brian Gabrielli, Charlotte Widberg, John F. Hancock, Andrew Goodall, Elizabeth Payne, Tanya Pike
Publikováno v:
Cellular Signalling. 25:1423-1428
The primary endpoint of signalling through the canonical Raf-MEK-ERK MAP kinase cascade is ERK activation. Here we report a novel signalling outcome for this pathway. Activation of the MAP kinase pathway by growth factors or phorbol esters during G2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55d0caf9fbaebf1a2ab1b27e5ec2463
https://doi.org/10.1016/j.cellsig.2013.03.014
https://doi.org/10.1016/j.cellsig.2013.03.014