Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nichole E. LaPointe"'
Autor:
Rebecca L. Best, Kevin Ruan, Leslie Wilson, Nichole E. LaPointe, Jiahao Liang, Madeleine F. Shade, Stuart C. Feinstein
Publikováno v:
The Journal of biological chemistry, vol 294, iss 33
J Biol Chem
J Biol Chem
The microtubule (MT)-associated protein tau regulates the critical growing and shortening behaviors of MTs, and its normal activity is essential for neuronal development and maintenance. Accordingly, aberrant tau action is tightly associated with Alz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5a2de53a785947324399fdcbc9080d
https://doi.org/10.1074/jbc.ra119.009124
https://doi.org/10.1074/jbc.ra119.009124
Autor:
Abhinaya Iyer, Nichole E Lapointe, Krzysztof Zielke, Mariusz Berdynski, Elmer Guzman, Anna Barczak, Małgorzata Chodakowska-Żebrowska, Maria Barcikowska, Stuart Feinstein, Cezary Zekanowski
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76409 (2013)
Over two dozen mutations in the gene encoding the microtubule associated protein tau cause a variety of neurodegenerative dementias known as tauopathies, including frontotemporal dementia (FTD), PSP, CBD and Pick's disease. The vast majority of these
Externí odkaz:
https://doaj.org/article/f20d01dc6d6a4752b89ec843954ba1dc
Autor:
Rebecca L. Best, Stephen Chih, Olga Azarenko, Nichole E. LaPointe, Herb P. Miller, Ben-Quan Shen, Nicola J. Stagg, Leslie Wilson, Christine Genualdi, Stuart C. Feinstein, Mary Ann Jordan
Publikováno v:
Toxicology and Applied Pharmacology. 421:115534
Monomethyl auristatin E (MMAE) is a potent anti-cancer microtubule-targeting agent (MTA) used as a payload in three approved MMAE-containing antibody drug conjugates (ADCs) and multiple ADCs in clinical development to treat different types of cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c347f080013425334e6d226e2cf654
https://doi.org/10.1016/j.taap.2021.115534
https://doi.org/10.1016/j.taap.2021.115534
Autor:
Nichole E. LaPointe, Natália E. C. de Almeida, Thanh D. Do, Stuart C. Feinstein, Michael Tro, Joan-Emma Shea, Michael T. Bowers
Publikováno v:
ACS Chemical Neuroscience. 7:218-226
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by extracellular deposits of amyloid β-protein (Aβ) in the brain. The conversion of soluble monomers to amyloid Aβ fibrils is a complicated process and involves several transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa12079b52dc59237c183b6a21f821dc
https://doi.org/10.1021/acschemneuro.5b00280
https://doi.org/10.1021/acschemneuro.5b00280
Autor:
Brett, Cook, Duncan, Proctor, Rachel, Bromberg, Nichole E, LaPointe, Stuart C, Feinstein, Leslie, Wilson
Publikováno v:
Methods in cell biology. 141
The proper organization and function of the mammalian nervous system relies on neuronal processes or "neurites," extended morphological projections that include axons and dendrites. Tau is a structural microtubule-associated protein that is widely ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f883641500f27db7aadbdf730075f2a
https://pubmed.ncbi.nlm.nih.gov/28882303
https://pubmed.ncbi.nlm.nih.gov/28882303
Autor:
Rebecca L, Best, Peter J, Chung, Sarah J, Benbow, April, Savage, Nichole E, LaPointe, Cyrus R, Safinya, Stuart C, Feinstein
Publikováno v:
Methods in cell biology. 141
In this chapter, we describe methods for the purification of both untagged and polyhistidine-tagged tau protein. These protocols utilize a bacterial expression system to produce the tau isoform of interest, followed by heat treatment and column chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8beb0d9466ceda2f106018b8642188e9
https://pubmed.ncbi.nlm.nih.gov/28882309
https://pubmed.ncbi.nlm.nih.gov/28882309
Publikováno v:
Methods in cell biology. 141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912bd718513ceb7807dd90e4e03e311e
https://pubmed.ncbi.nlm.nih.gov/28882314
https://pubmed.ncbi.nlm.nih.gov/28882314
Autor:
Stuart C. Feinstein, Joan-Emma Shea, Natália E. C. de Almeida, Nichole E. LaPointe, Thanh D. Do, Michael Tro, Michael T. Bowers
The early oligomerization of amyloid β-protein (Aβ) is a crucial step in the etiology of Alzheimer’s disease (AD), in which soluble and highly neurotoxic oligomers are produced and accumulated inside neurons. In search of therapeutic solutions fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea3c833c02aa4f742af07c5ddfb0d86
https://escholarship.org/uc/item/14q867m3
https://escholarship.org/uc/item/14q867m3
Autor:
Leslie Wilson, Nichole E. LaPointe, Mary Ann Jordan, Gregoriy Smiyun, Herbert P. Miller, Olga Azarenko, Alexander Rifkind
Publikováno v:
Cancer chemotherapy and pharmacology. 80(1)
Cabazitaxel is a novel taxane approved for treatment of metastatic hormone-refractory prostate cancer in patients pretreated with docetaxel. Cabazitaxel, docetaxel, and paclitaxel bind specifically to tubulin in microtubules, disrupting functions ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1353cc3d4127d086eb27c6e0d48b32e9
https://pubmed.ncbi.nlm.nih.gov/28567478
https://pubmed.ncbi.nlm.nih.gov/28567478
Autor:
Sarah J. Benbow, Peter J. Chung, Nichole E. LaPointe, Stuart C. Feinstein, Rebecca L. Best, Cyrus R. Safinya, April Savage
In this chapter, we describe methods for the purification of both untagged and polyhistidine-tagged tau protein. These protocols utilize a bacterial expression system to produce the tau isoform of interest, followed by heat treatment and column chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b32f14ac1d2ab42df19ffbdfbab4926
https://doi.org/10.1016/bs.mcb.2017.06.001
https://doi.org/10.1016/bs.mcb.2017.06.001