Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicholas Z. Lue"'
Autor:
Allison P. Siegenfeld, Shelby A. Roseman, Heejin Roh, Nicholas Z. Lue, Corin C. Wagen, Eric Zhou, Sarah E. Johnstone, Martin J. Aryee, Brian B. Liau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibi
Externí odkaz:
https://doaj.org/article/0dbe0b6e225542a5b5d44d310c2d1f55
Publikováno v:
Nature Chemical Biology. 19:176-186
Autor:
Emma M. Garcia, Nicholas Z. Lue, Jessica K. Liang, Whitney K. Lieberman, Derek D. Hwang, James Woods, Brian B. Liau
DNA methyltransferase 3A (DNMT3A) is ade novocytosine methyltransferase responsible for establishing proper DNA methylation during mammalian development. Loss-of-function (LOF) mutations to DNMT3A, including the hotspot mutation R882H, frequently occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbef8a35fd944d3eb9bc01fa861bf4be
https://doi.org/10.1101/2023.04.12.536656
https://doi.org/10.1101/2023.04.12.536656
Autor:
Kevin Chun-Ho Ngan, Samuel M Hoenig, Hui Si Kwok, Nicholas Z Lue, Pallavi M Gosavi, David A Tanner, Emma M Garcia, Ceejay Lee, Brian B Liau
Publikováno v:
eLife. 12
Allostery enables dynamic control of protein function. A paradigmatic example is the tightly orchestrated process of DNA methylation maintenance. Despite the fundamental importance of allosteric sites, their identification remains highly challenging.
Autor:
Kevin Chun-Ho Ngan, Samuel M Hoenig, Hui Si Kwok, Nicholas Z Lue, Pallavi M Gosavi, David A Tanner, Emma M Garcia, Ceejay Lee, Brian B Liau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5af23885b076db27413b07fe53044042
https://doi.org/10.7554/elife.80640.sa2
https://doi.org/10.7554/elife.80640.sa2
Publikováno v:
Curr Protoc
CRISPR-Cas9 genome editing technologies have enabled complex genetic manipulations in situ, including large-scale, pooled screening approaches to probe and uncover mechanistic insights across various biological processes. The RNA-programmable nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8ced9e7f301500a1bcc2759c8d95dd
https://europepmc.org/articles/PMC10073897/
https://europepmc.org/articles/PMC10073897/
Autor:
Emma M. Garcia, Nicholas Z. Lue, Keith Rivera, Maya Virshup, Jessica K. Liang, Derek D. Hwang, Steven A. Carr, Brian B. Liau
Publikováno v:
Biophysical Journal. 122:352a