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pro vyhledávání: '"Nicholas Z. Kerin"'
Autor:
Nicholas Z. Kerin
Publikováno v:
Cardiology. 140(3)
The pharmacologic treatment of arrhythmias has seen little advance over the past few years. Physicians treating life threatening or hemodynamically destabilizing arrhythmias depend almost entirely on intravenous (IV) amiodarone. This is regrettable d
Publikováno v:
American Journal of Therapeutics. 18:241-260
Atrial fibrillation (AF) is one of the most common arrhythmia encountered in clinical practice. Although AF is due to the structural and electrophysiological alterations in the atria, its sustainability is multifactorial, and the actual mechanisms ar
Autor:
Janos Molnar, Steven J. Bailin, John C. Somberg, Jozsef Borbola, Walter P Paladino, Istvan Sarosi, Sandor Timar, Jeno Tarjan, Ferenc Lakatos, Duane E. Bridges, Nicholas Z. Kerin, Charles I. Haffajee
Publikováno v:
The American Journal of Cardiology. 93:576-581
Hypotension is the most frequent adverse event reported with intravenous amiodarone. Hypotension has been attributed to the vasoactive solvents of the standard formulation (Cordarone IV) and is not dose related, but related to the rate of infusion. D
Autor:
Walter P Paladino, Janos Molnar, Duane E. Bridges, Nicholas Z. Kerin, Charles I. Haffajee, Sandor Timar, John C. Somberg, Steven J. Bailin
Publikováno v:
The American Journal of Cardiology. 90:853-859
The effectiveness of intravenous amiodarone for the treatment of incessant (shock resistant) ventricular tachycardia (VT) has not been established. This study evaluated the efficacy of a water-soluble amiodarone preparation or lidocaine for the treat
Publikováno v:
American Journal of Therapeutics. 5:59-66
The purpose of this study was to investigate the effect of multiple doses of orally administered isradipine on atrioventricular nodal conduction in patients with first-degree atrioventricular block. Forty-eight patients with a P-R interval > or =0.22
Autor:
H. E. Haber, Gerald C. Timmis, Robert Singer, William L. Meengs, David Salerno, Nicholas Z. Kerin
Publikováno v:
Cardiovascular Drugs and Therapy. 11:169-175
Procainamide is a class IA antiarrhythmic drug indicated for the treatment of life-threatening or symptomatic ventricular arrhythmias. The current sustained-release formulation requires 6-hour dosing (qid). To improve patient compliance, a new sustai
Autor:
Nicholas Z. Kerin, Kathy Faitel
Publikováno v:
American Journal of Therapeutics. 3:225-228
The effectiveness of an antiarrhythmic drug is judged by the degree of ventricular arrhythmia suppressed by the drug. It has been suggested that a certain degree of ventricular arrhythmia suppression should be targeted to prove efficacy. Targets used
Autor:
John C. Somberg, Nicholas Z. Kerin
Publikováno v:
American Heart Journal. 128:575-585
“Proarrhythmia” or “arrhythmogenicity” indicates the capacity of a cardiac or noncardiac drug to aggravate an existing arrhythmia or provoke a new arrhythmia at therapeutic or subtherapeutic levels. This definition excludes arrhythmias induce
Autor:
Nicholas Z. Kerin, Sony Jacob
Publikováno v:
The American journal of medicine. 124(9)
Objective Supraventricular tachyarrhythmias including atrial fibrillation are common and troubling complications after cardiac surgery, and thus considerable interest in pharmacologic prophylaxis has developed. The aim of this study was to evaluate t
Publikováno v:
American Heart Journal. 126:201-205
Proarrhythmic effects of nonantiarrhythmic drugs have not been as extensively studied or reported compared with the effects of antiarrhythmic drugs. The proarrhythmic incidence of many of these agents is not accurately known. In some instances, the f