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pro vyhledávání: '"Nicholas William Mazzanti"'
Autor:
Yuri Sykulev, Mizue Terai, Sergey Panteleev, Nicholas William Mazzanti, Nadia Anikeeva, Takami Sato
Publikováno v:
The Journal of Biological Chemistry
Although CAR-T cells are widely used to treat cancer, efficiency of CAR-T cell cytolytic responses has not been carefully examined. We engineered CAR specific for HMW-MAA (high-molecular-weight melanoma-associated antigen) and evaluated potency of CD
Publikováno v:
The Journal of Immunology. 198:73.17-73.17
Factors limiting highly sensitive and efficient responses of virus- and cancer-specific CTL have been extensively studied. However, the sensitivity and effectiveness of T cells transduced with CAR specific for target molecules on cancer cells have be