Výsledky vyhledávání - "Nicholas Willcox"

Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis

Autor: John Newsom-Davis, Daniel C. Douek, Nicholas Willcox, Camilla Buckley, Angela Vincent

Publikováno v: Annals of Neurology. 50:64-72

Antibodies to muscle acetylcholine receptors, to other muscle antigens, and to some cytokines are found in the majority of patients with thymic tumors (thymomas) and myasthenia gravis (MG). The role of the tumor in initiating autoimmunity, however, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c3cca941b118706ab677afa3555719
https://doi.org/10.1002/ana.1017

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Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: Clues to arthritogenic peptide motifs

Autor: Nicholas Willcox, Hidenori Matsuo, Shrikant Deshpande, Michael W. Nicolle, Paul C. Driscoll, Simon Hawke, Edward G. Spack, Paul Wordsworth, Louise Corlett

Publikováno v: Arthritis & Rheumatism. 42:1040-1050

Objective. To identify distinctive sequence motifs required for productive peptide presentation by those HLA-DR alleles/DR4 subtypes that predispose to rheumatoid arthritis (RA). Methods. We tested 10 different HLA-DR4 subtypes for presentation of ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fdee6f62bf108757758c199bc46bdb
https://doi.org/10.1002/1529-0131(199905)42:5<1040::aid-anr25>3.0.co

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Antibodies Affecting Ion Channel Function in Acquired Neuromyotonia, in Seropositive and Seronegative Myasthenia Gravis, and in Antibody-mediated Arthrogryposis Multiplex Congenita

Autor: Nicholas Willcox, Angela Vincent, Sara Ghorazian, Leslie Jacobson, Paul Plested, John Newsdom-Davis, Cal Maclenan, Jeremy Farrar, Agata Polizzi, Teresa Tang, Claire Newland, David Beeson, Sietske Riemersma

Publikováno v: Annals of the New York Academy of Sciences. 841:482-496

A new autoimmune disease affecting the neuromuscular junction has been defined. Acquired neuromyotonia is associated with antibodies to voltage-gated potassium channels that act, at least in part, by reducing potassium channel function with resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf32fa01a11365bc9149657bb3a31e0
https://doi.org/10.1111/j.1749-6632.1998.tb10968.x

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Differences in processing of an autoantigen by DR4:Dw4.2 and DR4:Dw14.2 antigen-presenting cells

Autor: Angela Vincent, Michael W. Nicolle, Nicholas Willcox, Simon Hawke

Publikováno v: European Journal of Immunology. 25:2119-2122

Variations in antigen processing can influence class II-restricted T cell responses. We now report a highly significant difference (p < 0.001) between the ability of antigen-presenting cells from three HLA-DR4:Dw14.2 (Arg71) and six DR4:Dw4.2 (Lys71)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f922e62627e069b08a5ffa20dc3e8f0e
https://doi.org/10.1002/eji.1830250749

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Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08

Publikováno v: Annals of neurology. 72(6)

OBJECTIVE: The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG). METHODS: We have carried out a 2-stage genome-wide association study on a total of 649 North European EOMG patients. Cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755c0e9bc5c173b6a5a15d56e97ab9b4
https://pubmed.ncbi.nlm.nih.gov/23055271

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Clonal expansions of CD4+ B helper T cells in autoimmune myasthenia gravis

Autor: Jens Kruth, Bernhard Hemmer, Wolfgang H. Oertel, Nicholas Willcox, Björn Tackenberg, Norbert Sommer, Kerstin Schlegel, Johanna E. Bartholomaeus

Publikováno v: European journal of immunology. 37(3)

The weakness in myasthenia gravis (MG) is mediated by T helper cell (Th)-dependent autoantibodies against neuromuscular epitopes. So far, analyzing Th phenotypes or antigen specificities has yielded very few clues to pathogenesis. Here we adopt an al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a5579d4febb2e2d8b3bd46d77c6c36
https://pubmed.ncbi.nlm.nih.gov/17323412

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Control of autoimmunity by 'epitope theft'

Autor: Nicholas Willcox, Kamil R. Kranc, Lars Fugger, Andrew M Taylor

Publikováno v: Trends in molecular medicine. 11(1)

We all possess T cells with autoaggressive potential. Knowledge of their regulation is crucial for elucidating pathogenetic pathways and designing effective treatments for autoimmune diseases. A novel mechanism of T-cell silencing – in an autoimmun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74466d46e03f0d68a33849c85e4dcff3
http://ora.ox.ac.uk/objects/uuid:fc97b82b-286b-4228-a17e-0ff84cf1c13b

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