Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nicholas Wheeler"'
Autor:
Yuk Yee Leung, Adam C. Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Amanda B. Kuzma, Wan-Ping Lee, Laura Cantwell, Heather Nicaretta, Alzheimer’s Disease Sequencing Project, Jonathan Haines, Lindsay Farrer, Sudha Seshadri, Zoran Brkanac, Carlos Cruchaga, Margaret Pericak-Vance, Richard P. Mayeux, William S. Bush, Anita Destefano, Eden Martin, Gerard D. Schellenberg, Li-San Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across nine studies and sequenced
Externí odkaz:
https://doaj.org/article/378dd02a30dd4635913bd42d5ec182d0
Autor:
Sultan Tousif, Anand P. Singh, Prachi Umbarkar, Cristi Galindo, Nicholas Wheeler, Angelica Toro Cora, Qinkun Zhang, Sumanth D. Prabhu, Hind Lal
Publikováno v:
Circulation Research. 132:267-289
Background: The tyrosine kinase inhibitor ponatinib is the only treatment option for chronic myelogenous leukemia patients with T315I (gatekeeper) mutation. Pharmacovigilance analysis of Food and Drug Administration and World Health Organization data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::853ec3ba880789977f881534cda955db
https://doi.org/10.1161/circresaha.122.321504
https://doi.org/10.1161/circresaha.122.321504
Publikováno v:
Expert Opinion on Drug Safety. 20:1443-1450
D-penicillamine (D-pen) is a copper-chelating drug and has immune-modulatory properties. D-pen is used to treat rheumatoid arthritis, Wilson's disease, and kidney stones (cystinuria). However, associated adverse events (AEs) of D-pen treatment are fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22867283940ab8f5b86226b4a6efdb50
https://doi.org/10.1080/14740338.2021.1956460
https://doi.org/10.1080/14740338.2021.1956460
Autor:
Prachi Umbarkar, Cristi L Galindo, Sultan Tousif, Anand Prakash Singh, Sumanth D. Prabhu, Nicholas Wheeler, Hind Lal, Qinkun Zhang
Publikováno v:
Circulation Research. 129
Background: Ponatinib is a third-generation tyrosine kinase inhibitor (TKI) for chronic myelogenous leukemia (CML) treatment. Of note, ponatinib is the only treatment option for CML patients with T315I (gatekeeper) mutation. Unexpected clinical cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3f1b300579091625321d39284120295
https://doi.org/10.1161/res.129.suppl_1.117
https://doi.org/10.1161/res.129.suppl_1.117
Autor:
Bowen Jin, John A. Capra, Penelope Benchek, Nicholas Wheeler, Adam C. Naj, Kara L. Hamilton-Nelson, John J. Farrell, Yuk Yee Leung, Brian Kunkle, Badri Vadarajan, Gerard D. Schellenberg, Richard Mayeux, Li-San Wang, Lindsay A. Farrer, Margaret A. Pericak-Vance, Eden R. Martin, Jonathan L. Haines, Dana C. Crawford, William S. Bush
Publikováno v:
Genome research. 32(4)
More than 90% of genetic variants are rare in most modern sequencing studies, such as the Alzheimer's Disease Sequencing Project (ADSP) whole-exome sequencing (WES) data. Furthermore, 54% of the rare variants in ADSP WES are singletons. However, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c477ee833520b7a6df4e2fd5066950
https://pubmed.ncbi.nlm.nih.gov/35210353
https://pubmed.ncbi.nlm.nih.gov/35210353
Autor:
Bowen Jin, John A. Capra, Penelope Benchek, Nicholas Wheeler, Adam C. Naj, Kara L. Hamilton-Nelson, John J. Farrell, Yuk Yee Leung, Brian Kunkle, Badri Vadarajan, Gerard D. Schellenberg, Richard Mayeux, Li-San Wang, Lindsay A. Farrer, Margaret A. Pericak-Vance, Eden R. Martin, Jonathan L. Haines, Dana C. Crawford, William S. Bush
Publikováno v:
Genome Research. 32:1228_1-1228_1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606a9642e9dbbc7a430ec0c8b453f108
https://doi.org/10.1101/gr.276900.122
https://doi.org/10.1101/gr.276900.122
Autor:
Lin Zhong, Cristi L. Galindo, Aaron Heck, Andrew Gutierrez, Cassandra P. Awgulewitsch, Marcus Negron, Gabrielle Kitchen, Nicholas Wheeler, Kylee Meece, Gabriel Herckerman
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1971c939b6851ba400bda20b92f3f3b8
https://doi.org/10.1096/fasebj.2021.35.s1.05498
https://doi.org/10.1096/fasebj.2021.35.s1.05498
Autor:
Emily Greenfest-Allen, Otto Valladares, Pavel P. Kuksa, Prabhakaran Gangadharan, Wan-Ping Lee, Jeffrey Cifello, Zivadin Katanic, Amanda B. Kuzma, Nicholas Wheeler, William S. Bush, Yuk Yee Leung, Gerard Schellenberg, Christian J. Stoeckert, Li-San Wang
INTRODUCTION: The NIAGADS Alzheimer9s Genomics Database is an interactive knowledgebase for AD genetics that provides access to GWAS summary statistics datasets deposited at NIAGADS, a national genetics data repository for AD and related dementia (AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a740b3bdbca6da559dec0e5882173082
https://doi.org/10.1101/2020.09.23.310276
https://doi.org/10.1101/2020.09.23.310276
Publikováno v:
Journal of Forestry. 113:500-510
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db86c8e503b1bda1ac3c9747563077e
https://doi.org/10.5849/jof.14-120
https://doi.org/10.5849/jof.14-120