Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas Wayham"'
Autor:
Rena A. Mizrahi, Wendy Y. Lin, Ashley Gras, Ariel R. Niedecken, Ellen K. Wagner, Sheila M. Keating, Nikita Ikon, Vishal A. Manickam, Michael A. Asensio, Jackson Leong, Angelica V. Medina-Cucurella, Emily Benzie, Kyle P. Carter, Yao Chiang, Robert C. Edgar, Renee Leong, Yoong Wearn Lim, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Dirk Büscher, Jose Vicente Terencio, Clara Di Germanio, Steven M. Chamow, Charles Olson, Paula A. Pino, Jun-Gyu Park, Amberlee Hicks, Chengjin Ye, Andreu Garcia-Vilanova, Luis Martinez-Sobrido, Jordi B. Torrelles, David S. Johnson, Adam S. Adler
Publikováno v:
Pathogens, Vol 11, Iss 7, p 806 (2022)
Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating infections where no treatment is available. This is especially important where multi-epitope neutral
Externí odkaz:
https://doaj.org/article/30fbcf61da8b46ddab93ba7e247ee57f
Autor:
Jan Fredrik Simons, Yoong Wearn Lim, Kyle P. Carter, Ellen K. Wagner, Nicholas Wayham, Adam S. Adler, David S. Johnson
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated an
Externí odkaz:
https://doaj.org/article/ac6112ed99b44416933c0b907771131b
Autor:
Eser Kirkizlar, Bernhard Zimmermann, Tudor Constantin, Ryan Swenerton, Bin Hoang, Nicholas Wayham, Joshua E. Babiarz, Zachary Demko, Robert J. Pelham, Stephanie Kareht, Alexander L. Simon, Kristine N. Jinnett, Matthew Rabinowitz, Styrmir Sigurjonsson, Matthew Hill
Publikováno v:
Translational Oncology, Vol 8, Iss 5, Pp 407-416 (2015)
We demonstrate proof-of-concept for the use of massively multiplexed PCR and next-generation sequencing (mmPCR-NGS) to identify both clonal and subclonal copy-number variants (CNVs) in circulating tumor DNA. This is the first report of a targeted met
Externí odkaz:
https://doaj.org/article/7d066fbaf8d04bb1b6461ca5636564b1
Autor:
Angélica V. Medina-Cucurella, Rena A. Mizrahi, Michael A. Asensio, Robert C. Edgar, Jackson Leong, Renee Leong, Yoong Wearn Lim, Ayla Nelson, Ariel R. Niedecken, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Adam S. Adler, David S. Johnson
Publikováno v:
Antibodies, Vol 8, Iss 1, p 17 (2019)
To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (
Externí odkaz:
https://doaj.org/article/4a06d9d0e77d4bfe97384b6e3af1b455
Autor:
Erica Stone, Kyle Carter, Ellen Wagner, Michael Asensio, Emily Benzie, Yao Chiang, Garry Coles, Chelsea Edgar, Bishal Gautam, Ashley Gras, Jackson Leong, Renee Leong, Vishal Manickam, Rena Mizrahi, Ariel Niedecken, Jasmeen Saini, Savreet Sandhu, Jan Fredrick Simons, Kacy Stadtmiller, Brendan Tinsley, LaRee Tracy, Nicholas Wayham, Yoong Wearn Lim, David Johnson, Adam Adler
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Christine V.F. Carrington, Steven M Chamow, Adam S. Adler, Matthew Adams, Sheila M. Keating, Emma Pearce, Ashley Gras, Robert C. Edgar, Charles Olson, Dirk Büscher, Jasmeen Saini, Kyle P Carter, Ariel R Niedecken, Heather E. Lynch, Rachel Mosher, Ellen K. Wagner, Vishal A. Manickam, Renee Leong, Bishal K. Gautam, Jan Fredrik Simons, Marcus O. Muench, Matthew J. Spindler, Jose Vicente Terencio, LaRee Tracy, Brendan Tinsley, Thomas H. Oguin, David S. Johnson, Yao Chiang, Nicholas Wayham, Everett Meyer, Rena A. Mizrahi, Anushka T. Ramjag, Carl A. Ross, Carina Vingsbo Lundberg, David Goldblatt, Matthew J Walch, Yoong Wearn Lim, Jackson Leong, Michael A. Asensio, Lucy Roalfe, Robert Jeanfreau, Emily Benzie, Christopher R. Bartley, Graham Simmons, Hayley Richardson, Bryan Monroe, Angélica V Medina-Cucurella, Kacy Stadtmiller
Publikováno v:
Nature biotechnology
Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient supply, and batch-to-batch variation. Here we describe a microfluidics and molecular genomic
Autor:
Kyle P Carter, Yao Y. Chiang, Vishal A. Manickam, Emily Benzie, Nicholas Wayham, David S. Johnson, Rena A. Mizrahi, Jasmeen Saini, Garry L. Coles, Savreet K. Sandhu, Eric A. Stone, Jan Fredrick Simons, Adam S. Adler, Ellen K. Wagner, Ashley Gras, Chelsea Edgar, LaRee Tracy, Brendan Tinsley, Jackson Leong, Kacy Stadtmiller, Ariel R Niedecken, Renee Leong, Yoong Wearn Lim, Bishal K. Gautam, Michael A. Asensio
Anti-CTLA-4 antibodies such as ipilimumab were among the first immune-oncology agents to show significantly improved outcomes for patients. However, existing anti-CTLA-4 therapies fail to induce a response in a majority of patients and can induce sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6edafd41945bb756870a8746a1366a
https://doi.org/10.1101/2021.07.12.452090
https://doi.org/10.1101/2021.07.12.452090
Autor:
Everett Meyer, David S. Johnson, Lucy Roalfe, Rena A. Mizrahi, Terencio Jv, David Goldblatt, Ariel R Niedecken, Marcus O. Muench, Jeanfreau R, Olson C, Heather E. Lynch, Matthew J. Spindler, Ashley Gras, Thomas H. Oguin, Emily Benzie, Graham Simmons, Kyle P Carter, Robert C. Edgar, Adam S. Adler, Emma Pearce, Yoong Wearn Lim, Kacy Stadtmiller, Jan Fredrik Simons, Hayley Richardson, Bishal K. Gautam, Renee Leong, Ellen K. Wagner, Angélica V Medina-Cucurella, Adams Ms, Chiang Y, Michael A. Asensio, Anushka T. Ramjag, LaRee Tracy, Brendan Tinsley, Jasmeen Saini, Jackson Leong, Christine V.F. Carrington, Sheila M. Keating, Monroe B, Carina Vingsbo Lundberg, Vishal A. Manickam, Chamow Sm, Büscher D, Nicholas Wayham
Plasma-derived polyclonal antibodies are polyvalent drugs used for many important clinical indications that require modulation of multiple drug targets simultaneously, including emerging infectious disease and transplantation. However, plasma-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b038c76143f6982660b22067931792
https://doi.org/10.1101/2020.08.05.232975
https://doi.org/10.1101/2020.08.05.232975
Autor:
Kyle P Carter, Jan Fredrik Simons, Adam S. Adler, Ellen K. Wagner, Nicholas Wayham, David S. Johnson, Yoong Wearn Lim
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated an
Autor:
Adam S. Adler, Kacy Stadtmiller, Angélica V Medina-Cucurella, Ayla Nelson, Jan Fredrik Simons, Robert C. Edgar, Matthew J. Spindler, Renee Leong, Ariel R Niedecken, Rena A. Mizrahi, David S. Johnson, Michael A. Asensio, Nicholas Wayham, Yoong Wearn Lim, Jackson Leong
Publikováno v:
Antibodies
Volume 8
Issue 1
Antibodies, Vol 8, Iss 1, p 17 (2019)
Volume 8
Issue 1
Antibodies, Vol 8, Iss 1, p 17 (2019)
To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (