Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicholas W. Warne"'
Autor:
Nicholas W. Warne, Mikael Dolsten, Kathy Fernando, John E. Burkhardt, Andrew E. Prigodich, Patrick Robert Verhoest, Charlotte Moira Norfor Allerton, Shuntai Wang
Publikováno v:
Drug discovery today. 26(10)
Innovation has a crucial role in developing breakthrough drugs and vaccines that can change patients’ lives. To better understand this role, we evaluated recent outcomes for assets developed using different types of innovation. Although all approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2dbb219574004284d9e204f9fd4d768
https://pubmed.ncbi.nlm.nih.gov/34015542
https://pubmed.ncbi.nlm.nih.gov/34015542
In this volume, the authors discuss the many significant challenges currently faced in biotechnology dosage form development, providing guidance, shared experience and thoughtful reflection on how best to address these potential concerns. As the fiel
Publikováno v:
Challenges in Protein Product Development ISBN: 9783319906010
Lifecycle management of biotherapeutic dosage forms has become an increasingly important strategy for providing patients with enhanced convenience during storage and administration as well as providing companies with an opportunity to compete in an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41d05515319240fd4e22dcec811e5e6b
https://doi.org/10.1007/978-3-319-90603-4_25
https://doi.org/10.1007/978-3-319-90603-4_25
Autor:
Patrick M. Buck, Satish K. Singh, Davin Boardman, Li Li, Nicholas Luksha, Nicholas W. Warne, Sandeep Kumar, Christopher J. Burns, Pilarin E. Nichols, Janelle Lavoie
Publikováno v:
Pharmaceutical Research. 31:3161-3178
Early identification of monoclonal antibody candidates whose development, as high concentration (≥100 mg/mL) drug products, could prove challenging, due to high viscosity, can help define strategies for candidate engineering and selection. Concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a938384ee98a046f37abd2401df8ed
https://doi.org/10.1007/s11095-014-1409-0
https://doi.org/10.1007/s11095-014-1409-0
Publikováno v:
Protein Science. 22:1118-1123
Previous publications demonstrated that the extrapolated solubility by polyethylene glycol (PEG) precipitation method (Middaugh et al., J Biol Chem 1979; 254:367–370; Juckes, Biochim Biophys Acta 1971; 229:535–546; Foster et al., Biochim Biophys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2d1e66fe24d9aa33dbe6951ab473b2
https://doi.org/10.1002/pro.2289
https://doi.org/10.1002/pro.2289
Publikováno v:
Journal of Pharmaceutical Sciences. 98:3145-3166
The purpose of this study is to investigate the impact of sucrose level on storage stability of dried proteins and thus better understand the mechanism of protein stabilization by disaccharides in lyophilized protein products. Five proteins were free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c7fbd8bd818b72b8f24a3a25844792
https://doi.org/10.1002/jps.21622
https://doi.org/10.1002/jps.21622
Autor:
Edward R. Lavallie, Maximillian Follettie, Elizabeth DiBlasio-Smith, Mark J. Williamson, John M. Mccoy, Zhijian Lu, Nicholas W. Warne, Lisa A. Collins-Racie, Kathleen L. Grant
Publikováno v:
Journal of Biological Chemistry. 271:5059-5065
A cluster of surface amino acid residues on Escherichia coli thioredoxin were systematically mutated in order to provide the molecule with an ability to chelate metal ions. The combined effect of two histidine mutants, E30H and Q62H, gave thioredoxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e565b91736b7999b53000150dc12298e
https://doi.org/10.1074/jbc.271.9.5059
https://doi.org/10.1074/jbc.271.9.5059
Autor:
Richard A. Kenley, Nicholas W. Warne
Publikováno v:
Pharmaceutical Research. 11:72-76
Recombinant human interleukin 11 (rhIL-11) is a multispectrum cytokine that plays an important role in megakaryocytopoiesis and platelet production. Probing rhIL-11 chemical reactivity in aqueous solution is an important initial step in developing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0648393f0367fa7fdc0132e505a369f1
https://doi.org/10.1023/a:1018945727640
https://doi.org/10.1023/a:1018945727640
Autor:
Nicholas W. Warne
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 78(2)
The development of highly concentrated solutions of monoclonal antibodies has become increasingly popular in biotechnology firms as doses increase, and the demand for sub-cutaneous injection formulations rises for reasons of convenience and complianc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d5f38ccb8d22f87f79be0cf090cae5
https://pubmed.ncbi.nlm.nih.gov/21406226
https://pubmed.ncbi.nlm.nih.gov/21406226
Autor:
Nicholas W. Warne, Wei Wang
Publikováno v:
Aggregation of Therapeutic Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb0fb5ef958624703438a544f63b8c28
https://doi.org/10.1002/9780470769829.ch8
https://doi.org/10.1002/9780470769829.ch8