Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Nicholas W. Seeds"'
Publikováno v:
Neurochemistry International. 63:476-481
Neuroserpin, the major inhibitor of tissue plasminogen activator (tPA) in brain, has been shown to be up-regulated in Alzheimer’s disease (AD). Inhibition of tPA activity leads to reduced brain levels of plasmin, one of the main enzymes responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae33bdc350c2e2e5ac03fa695d6c0bd1
https://doi.org/10.1016/j.neuint.2013.08.010
https://doi.org/10.1016/j.neuint.2013.08.010
Publikováno v:
Journal of Neurochemistry. 118:928-938
Amyloid-beta (Aβ) plaques are a hallmark of Alzheimer's disease. Several proteases including plasmin are thought to promote proteolytic cleavage and clearance of Aβ from brain. The activity of both plasmin and tissue plasminogen activator are reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbaae892738af81b0bc378abfa41dac
https://doi.org/10.1111/j.1471-4159.2011.07359.x
https://doi.org/10.1111/j.1471-4159.2011.07359.x
Autor:
Nicholas W. Seeds, Kenneth Minor, Steve Mikesell, Rebekah S. Vest, Thomas H. Bugge, Kristin Schaller
Publikováno v:
Cellular and Molecular Neurobiology. 31:961-967
Plasminogen activators play an important role in synaptic plasticity associated with the crossed phrenic phenomenon (CPP) and recovery of respiratory function after spinal cord injury. A genetic approach using knockout mice lacking various genes in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cef66fb8cab9e2e6a3c5819f571eb6
https://doi.org/10.1007/s10571-011-9701-6
https://doi.org/10.1007/s10571-011-9701-6
Publikováno v:
Respiratory Physiology & Neurobiology. 169:141-149
Plasminogen activators play an active role in synaptic plasticity associated with the crossed phrenic phenomenon (CPP) and recovery of respiratory function following spinal cord injury. A genetic approach has been used to identify molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93aaed5e16f5058184634b0c98135811
https://doi.org/10.1016/j.resp.2009.07.021
https://doi.org/10.1016/j.resp.2009.07.021
Publikováno v:
Journal of Neurochemistry. 109:706-715
Following CNS injury, myelin-associated inhibitors represent major obstacles to axonal regeneration and functional recovery. The following study suggests that the proteolytic enzyme tissue plasminogen activator (tPA) plays a major function in 'condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774506f4196eb7f322316db9b8511ab5
https://doi.org/10.1111/j.1471-4159.2009.05977.x
https://doi.org/10.1111/j.1471-4159.2009.05977.x
Autor:
Shay Fabbro, Nicholas W. Seeds
Publikováno v:
Journal of Neurochemistry. 109:303-315
Amyloid-beta plaques are a pathological hallmark of Alzheimer's disease. Several proteases are known to cleave/remove amyloid-beta, including plasmin, the product of tissue plasminogen activator cleavage of the pro-enzyme plasminogen. Although plasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c8405dd28db9b1498be9f714b57a2b
https://doi.org/10.1111/j.1471-4159.2009.05894.x
https://doi.org/10.1111/j.1471-4159.2009.05894.x
Autor:
Nicholas W. Seeds, Mark E. Basham
Publikováno v:
Journal of Neurochemistry. 77:318-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c31b45bb1316fdc0ced81a3e16cf4c7
https://doi.org/10.1046/j.1471-4159.2001.00239.x
https://doi.org/10.1046/j.1471-4159.2001.00239.x
Autor:
Janet M. Collins, Nicholas W. Seeds
Publikováno v:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 1(1)
γ-Amino butyric acid (GABA) appears to be the inhibitory transmitter of various cerebellar interneurons, while glutamate has been suggested as the excitatory transmitter of granule cells. In this study we have determined the developmental profile fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8754b8a340fb208f24e052b6439275d3
https://pubmed.ncbi.nlm.nih.gov/24875601
https://pubmed.ncbi.nlm.nih.gov/24875601
Autor:
Nicholas W. Seeds, Lisa B. Siconolfi
Publikováno v:
The Journal of Neuroscience. 21:4348-4355
Axonal outgrowth during peripheral nerve regeneration relies on the ability of growth cones to traverse through an environment that has been altered structurally and along a basal lamina sheath to reinnervate synaptic targets. To promote migration, g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c816f27a00817fa16601ad94ff5461
https://doi.org/10.1523/jneurosci.21-12-04348.2001
https://doi.org/10.1523/jneurosci.21-12-04348.2001
Autor:
Mark E. Basham, Nicholas W. Seeds
Publikováno v:
Journal of Neurochemistry. 77:318-325
Tissue-type plasminogen activator (tPA) has been implicated in a variety of types of neural plasticity, including cell migration, occlusion-induced visual system plasticity, and learning. In the periphery, plasminogen serves as tPA's primary substrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3ad6476b6429e43b391a459212da4d
https://doi.org/10.1046/j.1471-4159.2001.t01-1-00239.x
https://doi.org/10.1046/j.1471-4159.2001.t01-1-00239.x