Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nicholas W. Mathy"'
Autor:
Zinat Sharmin, Kehua Jin, Ai-Yu Gong, Silu Deng, Chansorena Pok, Marion L. Graham, Shuhong Wang, Nicholas W. Mathy, Annemarie Shibata, Xian-Ming Chen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Intestinal epithelial cells possess the requisite molecular machinery to initiate cell-intrinsic defensive responses against intracellular pathogens, including intracellular parasites. Interferons(IFNs) have been identified as cornerstones of epithel
Externí odkaz:
https://doaj.org/article/08639b7b6277458cbbca556868d87ac1
Autor:
Carly E. Baker, Aaron G. Marta, Nathan D. Zimmerman, Zeljka Korade, Nicholas W. Mathy, Delaney Wilton, Timothy Simeone, Andrew Kochvar, Kenneth L. Kramer, Holly A. F. Stessman, Annemarie Shibata
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 914 (2024)
Carnitine palmitoyltransferase 2 (CPT2) is an inner mitochondrial membrane protein of the carnitine shuttle and is involved in the beta-oxidation of long chain fatty acids. Beta-oxidation provides an alternative pathway of energy production during ea
Externí odkaz:
https://doaj.org/article/5c24584a562e4ca981f37d81f069ab52
Autor:
Nicholas W. Mathy, Olivia Burleigh, Andrew Kochvar, Erin R. Whiteford, Matthew Behrens, Patrick Marta, Cong Tian, Ai-Yu Gong, Kristen M. Drescher, Peter S. Steyger, Xian-Ming Chen, Annemarie Shibata
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Microglia are resident immunocompetent and phagocytic cells in the CNS. Pro-inflammatory microglia, stimulated by microbial signals such as bacterial lipopolysaccharide (LPS), viral RNAs, or inflammatory cytokines, are neurotoxic
Externí odkaz:
https://doaj.org/article/c05633b3953e4b29bcf9fdd58896b15f
Autor:
Nicholas W. Mathy, Silu Deng, Ai-Yu Gong, Min Li, Yang Wang, Olivia Burleigh, Andrew Kochvar, Erin R. Whiteford, Annemarie Shibata, Xian-Ming Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The cells of the intestinal epithelium establish the frontline for host defense against pathogens in the gastrointestinal tract and play a vital role in the initiation of the immune response. Increasing evidence supports the role of long non-coding R
Externí odkaz:
https://doaj.org/article/1682e4a1ea924a9bb2e96bcd602b762c
Autor:
Ai-Yu Gong, Yang Wang, Min Li, Xin-Tian Zhang, Silu Deng, Jessie M. Chen, Eugene Lu, Nicholas W. Mathy, Gislaine A. Martins, Juliane K. Strauss-Soukup, Xian-Ming Chen
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can
Externí odkaz:
https://doaj.org/article/0801779eeecf4115bddb57f5ae461f83
Autor:
Wei He, Juan Li, Ai-Yu Gong, Silu Deng, Min Li, Yang Wang, Nicholas W. Mathy, Yaoyu Feng, Lihua Xiao, Xian-Ming Chen
Publikováno v:
Microorganisms, Vol 9, Iss 1, p 151 (2021)
Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against
Externí odkaz:
https://doaj.org/article/5608871d399846c1aec7f8fbfc2eb853
Autor:
Annemarie Shibata, Erin R. Whiteford, Xian Ming Chen, Alex N. Eischeid, Kristi Lorenzen, Jing Chen, Nicholas W. Mathy, Matthew Behrens
Publikováno v:
Molecular Biology Reports
Emerging evidence suggests that microglia can support neurogenesis. Little is known about the mechanisms by which microglia regulate the cortical environment and stimulate cortical neurogenesis. We used an in vitro co-culture model system to investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044acd8a11d51f88985cc4edfbe6d8d9
http://europepmc.org/articles/PMC7884585
http://europepmc.org/articles/PMC7884585
Autor:
Xian Ming Chen, Nicholas W. Mathy, Tao Yu, Rongrong Liang, Ting Chen, Ji-Hao Xu, Ai-Yu Gong, Kuangyi Tian, Qi-Kui Chen
Publikováno v:
Oncology Reports
N6-methyladenosine (m6A) RNA modification maintained by N6-methyltransferases and demethylases is involved in multiple biological functions. Methyltransferase like 3 (METTL3) is a major N6-methyltransferase. However, the role of METTL3 and its instal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dc7e9b5f1bdd2d7ca26cc47761e4bd
https://doi.org/10.3892/or.2020.7665
https://doi.org/10.3892/or.2020.7665
Autor:
Xin-Tian Zhang, Silu Deng, Juliane K. Strauss-Soukup, Gislaine A. Martins, Yang Wang, Xian Ming Chen, Ai-Yu Gong, Min Li, Nicholas W. Mathy, Jessie M Chen, Eugene Lu
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
Interferon (IFN) signaling is key to mucosal immunity in the gastrointestinal tract, but cellular regulatory elements that determine interferon gamma (IFN-γ)-mediated antimicrobial defense in intestinal epithelial cells are not fully understood. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74587dc61a2ddd52029f053a6683144e
https://journals.asm.org/doi/10.1128/mBio.02127-21
https://journals.asm.org/doi/10.1128/mBio.02127-21
Autor:
Xian Ming Chen, Min Li, Juliane K. Strauss-Soukup, Gislaine A. Martins, Xin Tian Zhang, Yang Wang, Ai Yu Gong, Nicholas W. Mathy
Publikováno v:
The Journal of Immunology. 201:3630-3640
Cryptosporidium is an important opportunistic intestinal pathogen for immunocompromised individuals and a common cause of diarrhea in young children in developing countries. Gastrointestinal epithelial cells play a central role in activating and orch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e927a2226abc9e1e410c64da7cf4d20d
https://doi.org/10.4049/jimmunol.1800566
https://doi.org/10.4049/jimmunol.1800566