Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicholas W Florek"'
Autor:
Nicholas W Florek, Attapon Kamlangdee, James P Mutschler, Brock Kingstad-Bakke, Nancy Schultz-Darken, Karl W Broman, Jorge E Osorio, Thomas C Friedrich
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181738 (2017)
The rapid antigenic evolution of influenza viruses requires frequent vaccine reformulations. Due to the economic burden of continuous vaccine reformulation and the threat of new pandemics, there is intense interest in developing vaccines capable of e
Externí odkaz:
https://doaj.org/article/6b775ff51ce24d07b4679365e19c3efd
Publikováno v:
PLoS Pathogens
Identifying viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution. We describe a high-throughput approach to quantify the selection that monoclonal antibodies exert on all s
Autor:
Nicholas W. Florek, Emilia Caselli, Hollister C. Swanson, Robert A. Bonomo, Bradley J. Wallar, Fabio Prati, Magdalena A. Taracila, Rachel A. Powers, Chiara Romagnoli
Publikováno v:
Biochemistry
β-Lactam resistance in Acinetobacter baumannii presents one of the greatest challenges to contemporary antimicrobial chemotherapy. Much of this resistance to cephalosporins derives from the expression of the class C β-lactamase enzymes, known as Ac
Autor:
Nicholas W. Florek, Karl W. Broman, Masato Hatta, Subash C. Das, Jason T. Weinfurter, Thomas C. Friedrich, Tim D. Powell, Joseph N. Brewoo, Yoshihiro Kawaoka, Ginger Young, Stephen J. Kent, Susanne Gjeruldsen Dudman, Jorge E. Osorio, Dan T. Stinchcomb, Olav Hungnes, Sinthujan Jegaskanda
Publikováno v:
Journal of Virology. 88:13418-13428
Current influenza virus vaccines primarily aim to induce neutralizing antibodies (NAbs). Modified vaccinia virus Ankara (MVA) is a safe and well-characterized vector for inducing both antibody and cellular immunity. We evaluated the immunogenicity an
Autor:
Huong Q. McLean, Katarina M. Braun, Thomas C. Friedrich, Nicholas W. Florek, Brendan Flannery, Luiza M. Campos, Jennifer P. King, Edward A. Belongia
Publikováno v:
Vaccine. 36(5)
Influenza vaccination may provide a "back-boost" to antibodies against previously encountered strains. If the back-boost effect is common, this could allow more aggressive vaccine updates, as emerging variants would be expected to both elicit de-novo
Autor:
Brock Kingstad-Bakke, Karl W. Broman, Jorge E. Osorio, Thomas C. Friedrich, Nicholas W. Florek, Attapon Kamlangdee, Nancy Schultz-Darken, James Mutschler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0181738 (2017)
PLoS ONE, Vol 12, Iss 8, p e0181738 (2017)
The rapid antigenic evolution of influenza viruses requires frequent vaccine reformulations. Due to the economic burden of continuous vaccine reformulation and the threat of new pandemics, there is intense interest in developing vaccines capable of e
Autor:
Jorge M. Dinis, Nicholas W. Florek, Edward A. Belongia, Jennifer K. Meece, Omolayo O. Fatola, Olivia K. Charlier, James Mutschler, Louise H. Moncla, Thomas C. Friedrich
Publikováno v:
Journal of virology. 90(7)
Influenza vaccines must be frequently reformulated to account for antigenic changes in the viral envelope protein, hemagglutinin (HA). The rapid evolution of influenza virus under immune pressure is likely enhanced by the virus's genetic diversity wi
Autor:
Louise H. Moncla, Edward A. Belongia, Omolayo O. Fatola, James Mutschler, Olivia K. Charlier, Thomas C. Friedrich, Nicholas W. Florek, Jennifer K. Meece, Jorge M. Dinis
Publikováno v:
Journal of Virology. 90:8029-8029
Influenza vaccines must be frequently reformulated to account for antigenic changes in the viral envelope protein, hemagglutinin (HA). The rapid evolution of influenza virus under immune pressure is likely enhanced by the virus's genetic diversity wi