Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicholas V. Borrero"'
Autor:
Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens III, Frederic J. Kaye, Maria Zajac-Kaye
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Although thymidylate synthase (TYMS) inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells exploit for drug
Externí odkaz:
https://doaj.org/article/880157298af5466e978ad20aa4f783da
Autor:
Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens, Frederic J. Kaye, Maria Zajac-Kaye
Publikováno v:
Cancer Research. 82:4055-4055
Thymidylate synthase (TS) inhibitors are an integral component of chemotherapy regimens for difficult to treat cancer subtypes. Despite initial therapeutic benefit, current inhibitors induce TS overexpression or alter folate transport metabolism feed
Autor:
Shouguang Jin, Nicholas V. Borrero, Benjamin Q. Duong, Cristian Perez, James R. Rocca, Robert W. Huigens, Fang Bai
Publikováno v:
Org. Biomol. Chem.. 12:881-886
Nearly all clinically used antibiotics have been (1) discovered from microorganisms (2) using phenotype screens to identify inhibitors of bacterial growth. The effectiveness of these antibiotics is attributed to their endogenous roles as bacterial wa
Autor:
Aaron Aponick, Nicholas V. Borrero
Publikováno v:
The Journal of Organic Chemistry. 77:8410-8416
The total synthesis of acortatarin A relying on a Pd(II)-catalyzed spiroketalization is reported. This strategy allows a single stereocenter in the spiroketalization substrate to produce the target efficiently under mild conditions, installing the ne
Autor:
Lais Ferreira Barbosa, Khalil A. Abboud, Nicholas V. Borrero, Lindsey G. DeRatt, Aaron Aponick
Publikováno v:
ChemInform. 46
A gold-catalyzed synthesis of cyclic 2-oxodienes from readily prepared propargyl alcohols and the subsequent Diels—Alder reaction are reported.
Autor:
Khalil A. Abboud, Aaron Aponick, Nicholas V. Borrero, Lindsey G. DeRatt, Lais Ferreira Barbosa
Publikováno v:
Organic letters. 17(7)
A gold-catalyzed synthesis of cyclic 2-oxodienes from readily prepared propargyl alcohols and the subsequent Diels–Alder reaction are reported. The dehydrative cyclization reactions proceeded smoothly, and the dienes formed in situ were demonstrate