Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Nicholas V Hud"'
Autor:
Anton S Petrov, Chad R Bernier, Burak Gulen, Chris C Waterbury, Eli Hershkovits, Chiaolong Hsiao, Stephen C Harvey, Nicholas V Hud, George E Fox, Roger M Wartell, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88222 (2014)
Accurate secondary structures are important for understanding ribosomes, which are extremely large and highly complex. Using 3D structures of ribosomes as input, we have revised and corrected traditional secondary (2°) structures of rRNAs. We identi
Externí odkaz:
https://doaj.org/article/753e7f655e844b92ae3b749e03d9e869
Autor:
Shreyas S Athavale, J Jared Gossett, Jessica C Bowman, Nicholas V Hud, Loren Dean Williams, Stephen C Harvey
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54384 (2013)
Satellite tobacco mosaic virus (STMV) is a T = 1 icosahedral virus with a single-stranded RNA genome. It is widely accepted that the RNA genome plays an important structural role during assembly of the STMV virion. While the encapsidated form of the
Externí odkaz:
https://doaj.org/article/5c09eaad003243618e69e4dd2a23585b
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34166 (2012)
Many models for the origin of life have focused on understanding how evolution can drive the refinement of a preexisting enzyme, such as the evolution of efficient replicase activity. Here we present a model for what was, arguably, an even earlier st
Externí odkaz:
https://doaj.org/article/d22f2bb9819746a192cb19972633e377
Autor:
Shreyas S Athavale, Anton S Petrov, Chiaolong Hsiao, Derrick Watkins, Caitlin D Prickett, J Jared Gossett, Lively Lie, Jessica C Bowman, Eric O'Neill, Chad R Bernier, Nicholas V Hud, Roger M Wartell, Stephen C Harvey, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38024 (2012)
Mg²⁺ shares a distinctive relationship with RNA, playing important and specific roles in the folding and function of essentially all large RNAs. Here we use theory and experiment to evaluate Fe²⁺ in the absence of free oxygen as a replacement f
Externí odkaz:
https://doaj.org/article/68414350f7b84ae5b7fba11e7849ef2a
Autor:
Tyler P. Roche, Pranav J. Nedumpurath, Suneesh C. Karunakaran, Gary B. Schuster, Nicholas V. Hud
Publikováno v:
Life, Vol 13, Iss 11, p 2200 (2023)
Most contemporary theories for the chemical origins of life include the prebiotic synthesis of informational polymers, including strong interpretations of the RNA World hypothesis. Existing challenges to the prebiotic emergence of RNA have encouraged
Externí odkaz:
https://doaj.org/article/c5284636e0084d08af32a84476f634d5
Autor:
Moran Frenkel-Pinter, Jay W. Haynes, Ahmad M. Mohyeldin, Martin C, Alyssa B. Sargon, Anton S. Petrov, Ramanarayanan Krishnamurthy, Nicholas V. Hud, Loren Dean Williams, Luke J. Leman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support f
Externí odkaz:
https://doaj.org/article/ce86f8db408449cc807579afb0ac893f
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 344-349 (2019)
Externí odkaz:
https://doaj.org/article/669809fe836d49a9a99bb722017f3af3
Autor:
Nicholas V. Hud
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-4 (2018)
The nucleotides of RNA appear to be products of evolution. Experimental studies are showing that plausible proto-nucleotides can be formed in simulated early Earth environments. In turn, these results help to clarify the prebiotic processes that give
Externí odkaz:
https://doaj.org/article/cc3609935234499ba2c45dca17822b32
Publikováno v:
The Journal of Physical Chemistry B. 126:10758-10767
Understanding the interactions and thermodynamic parameters that govern the structure and stability of supramolecular polymers is challenging because of their flexible nature and high sensitivity to weak intermolecular interactions. The application o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9de3ac1dca014719374bcf53113988
https://doi.org/10.1021/acs.jpcb.2c05934
https://doi.org/10.1021/acs.jpcb.2c05934
Autor:
Moran Frenkel-Pinter, Kaitlin C. Jacobson, Jonathan Eskew-Martin, Jay G. Forsythe, Martha A. Grover, Loren Dean Williams, Nicholas V. Hud
Publikováno v:
Life, Vol 12, Iss 2, p 265 (2022)
The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids. It is likely that the prebiotic forerunners of proteins, or protopeptid
Externí odkaz:
https://doaj.org/article/b72948f0feba4f9bbc863250f99e04f8