Výsledky vyhledávání - "Nicholas U, Raja"

Multi-antigen vaccines based on complex adenovirus vectors induce protective immune responses against H5N1 avian influenza viruses

Autor: John Y. Dong, David H. Holman, Danher Wang, Nicholas U. Raja, Nutan Mytle, Min Luo, Kevin M. Moore, Jan Woraratanadharm

Publikováno v: Vaccine. 26:2627-2639

There are legitimate concerns that the highly pathogenic H5N1 avian influenza virus could adapt for human-to-human transmission and cause a pandemic similar to the 1918 "Spanish flu" that killed 50 million people worldwide. We have developed pandemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ed7f55ab4f11afd0097e1306fe38c5
https://doi.org/10.1016/j.vaccine.2008.02.053

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INDUCTION OF BIVALENT IMMUNE RESPONSES BY EXPRESSION OF DENGUE VIRUS TYPE 1 AND TYPE 2 ANTIGENS FROM A SINGLE COMPLEX ADENOVIRAL VECTOR

Autor: Laure Y. Juompan, Jianghui Zhang, Nicholas U. Raja, David H. Holman, Stephen B. Deitz, Danher Wang, Min Luo, Kevin R. Porter, John Y. Dong, Kanakatte Raviprakash

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 76:743-751

There are approximately 100 million new cases of dengue (DEN) virus infection each year. Infection can result in illness ranging from a mild fever to hemorrhaging, shock, or even death. There are four serotypes of dengue virus (DEN1-4), and immunity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f2cb12bfc1ba09dbaf3e4b4591e6fa6
https://doi.org/10.4269/ajtmh.2007.76.743

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Two Complex, Adenovirus-Based Vaccines That Together Induce Immune Responses to All Four Dengue Virus Serotypes

Autor: Danher Wang, Kanakatte Raviprakash, Nicholas U. Raja, Kevin R. Porter, Jianghui Zhang, John Y. Dong, Min Luo, David H. Holman

Publikováno v: Clinical and Vaccine Immunology

Dengue virus infections can cause hemorrhagic fever, shock, encephalitis, and even death. Worldwide, approximately 2.5 billion people live in dengue-infested regions with about 100 million new cases each year, although many of these infections are be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d051879cdb8e94232c4933e74f4fc124

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Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges

Autor: Min Luo, Stephen B. Deitz, Michael Hevey, Laure Y. Juompan, Charles M. Trubey, Kevin M. Moore, Jan Woraratanadharm, Nicholas U. Raja, Hong Yu, Danher Wang, John Y. Dong, Benjamin M. Swain

Publikováno v: Virology. 353(2):324-332

The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5bff7293c7a1d2b1e9426ad5988089

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De novo syntheses of Marburg virus antigens from adenovirus vectors induce potent humoral and cellular immune responses

Autor: Charles M. Trubey, Nicholas U. Raja, Alan L. Schmaljohn, Benjamin M. Swain, William D. Pratt, Kevin M. Moore, Min Luo, Hong Yu, Danher Wang, David H. Holman, Jan Woraratanadharm, Laure Y. Juompan, John Y. Dong, Stephen B. Deitz

Publikováno v: Vaccine. 24:2975-2986

Marburg virus (MARV) is an African filovirus that causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, there are no MARV vaccines or therapies approved for human use. We hypothesized that developing a vaccine that induces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b550553f7162f38aacc5a6981712c472
https://doi.org/10.1016/j.vaccine.2005.11.046

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Development of a cAdVax-Based Bivalent Ebola Virus Vaccine That Induces Immune Responses against both the Sudan and Zaire Species of Ebola Virus

Autor: Min Luo, Jan Woraratanadharm, John Y. Dong, Laure Y. Juompan, Stephen B. Deitz, Nicholas U. Raja, William D. Pratt, Kevin M. Moore, Hong Yu, Benjamin M. Swain, Danher Wang, Mary Kate Hart, Charles M. Trubey

Publikováno v: Journal of Virology. 80:2738-2746

Ebola virus (EBOV) causes a severe hemorrhagic fever for which there are currently no vaccines or effective treatments. While lethal human outbreaks have so far been restricted to sub-Saharan Africa, the potential exploitation of EBOV as a biological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc4b36ed1f159605ad165d18ace714a
https://doi.org/10.1128/jvi.80.6.2738-2746.2006

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Analysis of endoproteolytic cleavage and intracellular transport of human immunodeficiency virus type 1 envelope glycoproteins using mutant CD4 molecules bearing the transmembrane endoplasmic reticulum retention signal

Autor: M A Jabbar, Nicholas U. Raja, Martin J. Vincent

Publikováno v: Journal of General Virology. 74:2085-2097

We investigated endoproteolytic processing of the human immunodeficiency virus (HIV) envelope glycoprotein precursor, gp160, as well as envelope-mediated membrane fusion in the presence of CD4 molecules that were either partially or fully retained in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2251594953847b2204519b3edf453c3
https://doi.org/10.1099/0022-1317-74-10-2085

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Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum

Autor: Martin J. Vincent, Nicholas U. Raja, M A Jabbar

Publikováno v: Journal of Virology. 67:5538-5549

The human immunodeficiency virus type 1 (HIV-1) Vpu protein is a transmembrane phosphoprotein which induces rapid degradation of CD4 in the endoplasmic reticulum (ER). To identify sequences in CD4 for Vpu-induced degradation, we generated four chimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7989639f9f612a72905f94de166822ca
https://doi.org/10.1128/jvi.67.9.5538-5549.1993

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Induction of bivalent immune responses by expression of dengue virus type 1 and type 2 antigens from a single complex adenoviral vector

Autor: Nicholas U, Raja, David H, Holman, Danher, Wang, Kanakatte, Raviprakash, Laure Y, Juompan, Stephen B, Deitz, Min, Luo, Jianghui, Zhang, Kevin R, Porter, John Y, Dong

Publikováno v: The American journal of tropical medicine and hygiene. 76(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d0edefdef7cb62aaecc148da32a3d4e
https://pubmed.ncbi.nlm.nih.gov/17426182

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Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vpu Transmembrane Domain That Promotes the Enhanced Release of Virus-Like Particles from the Plasma Membrane of Mammalian Cells

Autor: Nicholas U. Raja, Suparna Mazumder, Mousumi Paul, M.Abdul Jabbar

Human immunodeficiency virus type 1 Vpu is a multifunctional phosphoprotein composed of the N-terminal transmembrane (VpuTM) and C-terminal cytoplasmic domains. Each of these domains regulates a distinct function of the protein; the transmembrane dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed0c03e25eb40db76270066d97fc8ca
https://europepmc.org/articles/PMC124605/

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