Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nicholas Treen"'
Autor:
Nicholas Treen, Shunsuke F. Shimobayashi, Jorine Eeftens, Clifford P. Brangwynne, Michael Levine
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of He
Externí odkaz:
https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc
Publikováno v:
Developmental Biology. 498:26-34
Publikováno v:
Genes & Development. 37:80-85
Zygotic genome activation has been extensively studied in a variety of systems including flies, frogs, and mammals. However, there is comparatively little known about the precise timings of gene induction during the earliest phases of embryogenesis.
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Phase separation underlies the organization of the nucleus, including the biogenesis of nucleoli and the packaging of heterochromatin. Here we explore the regulation of transcription factor condensates involved in gene repression by ERK signaling in
Autor:
Yasunori Sasakura, Yukako Tajima, Nicholas Treen, Takashi Yamamoto, Keita Yoshida, Akiko Hozumi, Tetsushi Sakuma
Publikováno v:
Developmental Biology. 458:120-131
Species-specific traits are thought to have been acquired by natural selection. Transcription factors play central roles in the evolution of species-specific traits. Hox genes encode a set of conserved transcription factors essential for establishing
Autor:
Jorine M. Eeftens, Clifford P. Brangwynne, Nicholas Treen, Michael Levine, Shunsuke F. Shimobayashi
There is emerging evidence for transcription condensates in the activation of gene expression1–3. However, there is considerably less information regarding transcriptional repression, despite its pervasive importance in regulating gene expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7604b3f7c50839214d7ecdf9782f78
Autor:
Keisuke Sakurai, Takashi Yamamoto, Yasunori Sasakura, Kaoru Mita, Takaho Sugihara, Mayuko Hamada, Akira Shiraishi, Tetsushi Sakuma, Noriyuki Satoh, Honoo Satake, Takeo Horie, Shohei Matsunobu, Nicholas Treen, Akiko Hozumi
Publikováno v:
Current Biology. 30:1555-1561.e4
Metamorphosis, a widespread life history strategy in metazoans, allows dispersal and use of different ecological niches through a dramatic body change from a larval stage [1, 2]. Despite its conservation and importance, the molecular mechanisms under
Autor:
Keita Yoshida, Nicholas Treen
Publikováno v:
Transgenic Ascidians ISBN: 9789811075445
Targeted mutagenesis of genes-of-interest is a powerful method of addressing the functions of genes. Genome editing techniques, such as transcriptional activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcbd84edd47689f27872495f1130691d
https://doi.org/10.1007/978-981-10-7545-2_12
https://doi.org/10.1007/978-981-10-7545-2_12
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1630
The ascidian Ciona intestinalis is an important model animal for studying developmental mechanisms for constructing the chordate body. Although molecular and embryological techniques for manipulating Ciona genes were developed a long time ago, recent
Autor:
Azusa Nakahata, Takashi Yamamoto, Keita Yoshida, Nicholas Treen, Yasunori Sasakura, Tetsushi Sakuma
Publikováno v:
Development.
The pharynx, possessing gill slits and the endostyle, is a characteristic of chordates that is a complex of multiple tissues well organized along the anterior-posterior (AP) axis. Although Hox genes show AP coordinated expression in the pharyngeal en