Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicholas Tolwinski"'
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the development of associated pathologies after surgeries with contaminated instruments and intr
Externí odkaz:
https://doaj.org/article/138af1cc6e0145c7ac61284247af3f6e
Autor:
Maximilian Unfried, Li Fang Ng, Amaury Cazenave-Gassiot, Krishna Chaithanya Batchu, Brian K. Kennedy, Markus R. Wenk, Nicholas Tolwinski, Jan Gruber
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Complexity is a fundamental feature of biological systems. Omics techniques like lipidomics can simultaneously quantify many thousands of molecules, thereby directly capturing the underlying biological complexity. However, this approach transfers the
Externí odkaz:
https://doaj.org/article/2a96c447671244d59c6b41d401f2d7b2
Autor:
Emelyne Teo, Soon Yew John Lim, Sheng Fong, Anis Larbi, Graham D. Wright, Nicholas Tolwinski, Jan Gruber
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 11-21 (2020)
Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD manifests on several scales (molecular, cellular
Externí odkaz:
https://doaj.org/article/2c7e77291e524e2eb5996ee15a6c1919
Autor:
Emelyne Teo, Sudharshan Ravi, Diogo Barardo, Hyung-Seok Kim, Sheng Fong, Amaury Cazenave-Gassiot, Tsze Yin Tan, Jianhong Ching, Jean-Paul Kovalik, Markus R Wenk, Rudiyanto Gunawan, Philip K Moore, Barry Halliwell, Nicholas Tolwinski, Jan Gruber
Publikováno v:
eLife, Vol 8 (2019)
Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key event in the etiology of AD. We have previously modeled amyloid-beta (Aβ)-induced mitochond
Externí odkaz:
https://doaj.org/article/eb3eb4a1028f48789394b89e79678ebd
Autor:
Li Zhou, Mandy Yu Theng Lim, Prameet Kaur, Abil Saj, Diane Bortolamiol-Becet, Vikneswaran Gopal, Nicholas Tolwinski, Greg Tucker-Kellogg, Katsutomo Okamura
Publikováno v:
eLife, Vol 7 (2018)
Mature microRNAs (miRNAs) are processed from primary transcripts (pri-miRNAs), and their expression is controlled at transcriptional and post-transcriptional levels. However, how regulation at multiple levels achieves precise control remains elusive.
Externí odkaz:
https://doaj.org/article/c9772bd6dd7c4c899dfdf3fba6adcffc
Autor:
Nicholas Tolwinski, Prabhat Tiwari
Publikováno v:
International Journal of Molecular Sciences. 24:4300
Across the world a dementia case is diagnosed every three seconds. Alzheimer’s disease (AD) causes 50–60% of these cases. The most prominent theory for AD correlates the deposition of amyloid beta (Aβ) with the onset of dementia. Whether Aβ is
Autor:
Maximilian Unfried, Li Fang Ng, Amaury Cazenave-Gassiot, Krishna Chaithanya Batchu, Brian K. Kennedy, Markus R. Wenk, Nicholas Tolwinski, Jan Gruber
Publikováno v:
Frontiers in aging. 3
Complexity is a fundamental feature of biological systems. Omics techniques like lipidomics can simultaneously quantify many thousands of molecules, thereby directly capturing the underlying biological complexity. However, this approach transfers the