Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nicholas T. Salzameda"'
Autor:
Cecilia Rodriguez, Dema Ramlaoui, Nardin Georgeos, Briea Gasca, Camila Leal, Tomás Subils, Marisel R. Tuttobene, Rodrigo Sieira, Nicholas T. Salzameda, Robert A. Bonomo, Raúl Raya, María Soledad Ramirez
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Carbapenem-resistant Acinetobacter baumannii (CRAB) is a recognized nosocomial pathogen with limited antibiotic treatment options. Lactic acid bacteria (LAB) constitute a promising therapeutic alternative. Here we studied the antibacterial p
Externí odkaz:
https://doaj.org/article/b40dd5a3884e4382b2014e363efb0f62
Autor:
Nicholas T. Salzameda, Scott D. Rychnovsky, Wendy T. Dao, Bo Qu, Christina Mitilian, Charles J. Dooley, Alexander Burtea
Publikováno v:
The Journal of Organic Chemistry. 85:10750-10759
The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode's chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa449f8af3a23cc9669f55c7a695194
https://doi.org/10.1021/acs.joc.0c01275
https://doi.org/10.1021/acs.joc.0c01275
Autor:
Martin Amezcua, Ricardo S. Cruz, Alex Ku, Wilfred Moran, Marcos E. Ortega, Nicholas T. Salzameda
Publikováno v:
Toxicon. 214:S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4be38e925662eb61600a0ae00daa3f
https://doi.org/10.1016/j.toxicon.2021.11.017
https://doi.org/10.1016/j.toxicon.2021.11.017
Autor:
Marcos E. Ortega, Alex Ku, Wilfred Moran, Martin Amezcua, Nicholas T. Salzameda, Ricardo Saul Cruz
Publikováno v:
ACS Med Chem Lett
[Image: see text] The botulinum neurotoxin, the caustic agent that causes botulism, is the most lethal toxin known to man. The neurotoxin composed of a heavy chain (HC) and a light chain (LC) enters neurons and cleaves SNARE proteins, leading to flac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927bbf77dd0c2ebbc5b5a0858995ced9
https://pubmed.ncbi.nlm.nih.gov/33603978
https://pubmed.ncbi.nlm.nih.gov/33603978
Autor:
Alejandra Y. Palomino, Thanh Lien, Jordan C. Thompson, Martin Amezcua, Sandra L. Rodriguez-Beltran, Alex Ku, Nicholas T. Salzameda, Wendy T. Dao
Publikováno v:
Bioorganicmedicinal chemistry. 28(18)
The botulinum neurotoxin (BoNT) is the most lethal protein known to man causing the deadly disease botulinum. The neurotoxin, composed of a heavy (HC) and light (LC) chain, work in concert to cause muscle paralysis. A therapeutic strategy to treat in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be47b7de2660d75201a2296e5d075e8
https://pubmed.ncbi.nlm.nih.gov/32828426
https://pubmed.ncbi.nlm.nih.gov/32828426
Publikováno v:
Journal of Chemical Education. 93:1460-1463
We present a novel guided inquiry second semester organic chemistry laboratory rearrangement experiment. Students performed the Favorskii Rearrangement to obtain methyl cyclopentanecarboxylate in good yields. The students learned about the individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7674cdf875e1d8f7333b5fca7cf6f5b6
https://doi.org/10.1021/acs.jchemed.5b00588
https://doi.org/10.1021/acs.jchemed.5b00588
Autor:
Anastasia A. Martinez, Bianca A. Espinosa, Niroshika Keppetipola, Nicholas T. Salzameda, Rebecca N. Adamek, Brent A. Thomas, Jennifer Chau, Edwardo Gonzalez
Publikováno v:
European journal of medicinal chemistry. 157
The West Nile virus (WNV) has spread throughout the world causing neuroinvasive diseases with no treatments available. The viral NS2B-NS3 protease is essential for WNV survival and replication in host cells and is a promising drug target. Through an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3989c99d075ea71802f495f90a98fe5
https://pubmed.ncbi.nlm.nih.gov/30193218
https://pubmed.ncbi.nlm.nih.gov/30193218
Publikováno v:
Med. Chem. Commun.. 5:706-710
Through the use of chemical synthesis and high throughput screening, we discovered a sulfonamide hydroxamic acid inhibitor for the botulinum neurotoxin serotype A light chain. A structure activity relationship study of the parent inhibitor resulted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27a1db605f140f8ec38db7c49da04ba6
https://doi.org/10.1039/c4md00053f
https://doi.org/10.1039/c4md00053f
Publikováno v:
Supramolecular Chemistry. 23:226-238
Hydrogen bonding between carboxylic acid and amide groups was demonstrated for a series of amides called [n]-semirubins consisting of a dipyrrinone attached to the end of an n-carbon alkanoic acid. Such hydrogen bonding is more effective than the alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d08b94c5b5d231f9dc532aa4ad67d0
https://doi.org/10.1080/10610278.2010.521836
https://doi.org/10.1080/10610278.2010.521836
Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease
Autor:
Mark S. Hixon, Lisa M. Eubanks, Joseph S. Zakhari, Feng Xiaochuan, Charles B. Shoemaker, Kim D. Janda, Joseph T. Barbieri, Nicholas T. Salzameda, Peter Šilhár
Publikováno v:
ACS Medicinal Chemistry Letters. 1:268-272
Botulinum neurotoxins (BoNTs) are the etiological agents responsible for botulism, a disease characterized by peripheral neuromuscular blockade and a characteristic flaccid paralysis of humans. BoNTs are the most lethal known poisons affecting humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359850738acc0e227d182a0ddd509ed1
https://doi.org/10.1021/ml100074s
https://doi.org/10.1021/ml100074s