Defining the proteolytic landscape during enterovirus infection.

Autor: Mohsan Saeed, Sebastian Kapell, Nicholas T Hertz, Xianfang Wu, Kierstin Bell, Alison W Ashbrook, Milica Tesic Mark, Henry A Zebroski, Maxwell L Neal, Malin Flodström-Tullberg, Margaret R MacDonald, John D Aitchison, Henrik Molina, Charles M Rice

Publikováno v: PLoS Pathogens, Vol 16, Iss 9, p e1008927 (2020)

Viruses cleave cellular proteins to remodel the host proteome. The study of these cleavages has revealed mechanisms of immune evasion, resource exploitation, and pathogenesis. However, the full extent of virus-induced proteolysis in infected cells is

Externí odkaz: https://doaj.org/article/a0af98e83ecb4080aebefd1e79bfc91f

Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain

Autor: Michael P. Dugan, Laura B. Ferguson, Nicholas T. Hertz, Robert J. Chalkley, Alma L. Burlingame, Kevan M. Shokat, Peter J. Parker, Robert O. Messing

Publikováno v: Molecular & cellular proteomics : MCP, vol 22, iss 4
Mol Cell Proteomics

Protein kinase C epsilon (PKCε) plays important roles in behavioral responses to alcohol and in anxiety-like behavior in rodents, making it a potential drug target for reducing alcohol consumption and anxiety. Identifying signals downstream of PKCε

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab9ce87ea8b634bfa042889711baa16
https://escholarship.org/uc/item/5jw1n92s

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

Autor: Courtney M Schroeder, Jonathan ML Ostrem, Nicholas T Hertz, Ronald D Vale

Publikováno v: eLife, Vol 3 (2014)

Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor hea

Externí odkaz: https://doaj.org/article/fb088b2b884a4368904703967d69fa52

p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin

Autor: Aminah A. Loonat, James Clark, Katharina Tilgner, Pelin Arabacilar, Nicholas T. Hertz, Max Thomas, Michael S. Marber, Negin Sarafraz-Shekary, Kevan M. Shokat, E Denise Martin, Alma L. Burlingame, Shahzan Uddin, Rebecca S. Levin

Publikováno v: Loonat, A A, Martin, E D, Sarafraz-Shekary, N, Tilgner, K, Hertz, N T, Levin, R, Shokat, K M, Burlingame, A L, Arabacilar, P, Uddin, S, Thomas, M, Marber, M S & Clark, J E 2019, ' p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin ', Faseb Journal, vol. 33, no. 12, pp. 13131-13144 . https://doi.org/10.1096/fj.201701545R

Despite the high and preferential expression of p38γ MAPK in the myocardium, little is known about its function in the heart. The aim of the current study was to elucidate the physiologic and biochemical roles of p38γ in the heart. Expression and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6495c6e9f2f2092f9b7c4ede0c6d39e
https://kclpure.kcl.ac.uk/ws/files/123773029/fj.201701545r.pdf

Neuronally-enriched RUFY3 is Required for Caspase-Mediated Axon Degeneration

Autor: Charles W. Morgan, Melanie K. O’Rourke, David J. Simon, Nicholas Sinnott Armstrong, Michael C. Bassik, Rebecca J. Shen, Olav Olsen, Trevor R. Mileur, Henry Zebroski, Ross A. Weber, Michael Wainberg, James A. Wells, Angela M. Hitchcock, Marc Tessier-Lavigne, Henrik Molina, Eliza L. Adams, Nicholas T. Hertz

Publikováno v: Neuron

Summary Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09848c781caaf292a12fe7324925aaa5
https://europepmc.org/articles/PMC8024238/