Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicholas T Henthorn"'
Autor:
Samuel P Ingram, Nicholas T Henthorn, John W Warmenhoven, Norman F Kirkby, Ranald I Mackay, Karen J Kirkby, Michael J Merchant
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008476 (2020)
Developments in the genome organisation field has resulted in the recent methodology to infer spatial conformations of the genome directly from experimentally measured genome contacts (Hi-C data). This provides a detailed description of both intra- a
Externí odkaz:
https://doaj.org/article/bca859834a4142c2833468df353a8cd5
Autor:
Hannah C. Wanstall, Pierre Korysko, Wilfred Farabolini, Roberto Corsini, Joseph J. Bateman, Vilde Rieker, Abigail Hemming, Nicholas T. Henthorn, Michael J. Merchant, Elham Santina, Amy L. Chadwick, Cameron Robertson, Alexander Malyzhenkov, Roger M. Jones
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical ener
Externí odkaz:
https://doaj.org/article/61a9decb02b44d5288fc685095853dbb
Autor:
Hannah C. Wanstall, Florian Burkart, Hannes Dinter, Max Kellermeier, Willi Kuropka, Frank Mayet, Thomas Vinatier, Elham Santina, Amy L. Chadwick, Michael J. Merchant, Nicholas T. Henthorn, Michael Köpke, Blae Stacey, Sonja Jaster-Merz, Roger M. Jones
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Very high energy electrons (VHEE) are a potential candidate for radiotherapy applications. This includes tumours in inhomogeneous regions such as lung and prostate cancers, due to the insensitivity of VHEE to inhomogeneities. This study expl
Externí odkaz:
https://doaj.org/article/bfb410ec9cca477e9bd0fe99839476d7
Autor:
Nickolay Korabel, John W. Warmenhoven, Nicholas T. Henthorn, Samuel Ingram, Sergei Fedotov, Charlotte J. Heaven, Karen J. Kirkby, Michael J. Taylor, Michael J. Merchant
Publikováno v:
Entropy, Vol 26, Iss 6, p 502 (2024)
The process of end-joining during nonhomologous repair of DNA double-strand breaks (DSBs) after radiation damage is considered. Experimental evidence has revealed that the dynamics of DSB ends exhibit subdiffusive motion rather than simple diffusion
Externí odkaz:
https://doaj.org/article/b1ffe8c2c55749f8912a4a623ebb2857
Autor:
Samuel P. Ingram, John-William Warmenhoven, Nicholas T. Henthorn, Amy L. Chadiwck, Elham E. Santina, Stephen J. McMahon, Jan Schuemann, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
PyFoci is a tool that simulates distributions of fluorescently labeled DNA double-strand break marker protein foci and allows the estimation of miscounting under different radiation types, doses and microscopy settings.
Externí odkaz:
https://doaj.org/article/12f2d24396fc42b6b08bfd133060527c
Autor:
Hannah C Wanstall, Nicholas T Henthorn, James Jones, Elham Santina, Amy L Chadwick, Deepa Angal-Kalinin, Geoffrey Morris, John-William Warmenhoven, Rob Smith, Storm Mathisen, Michael J Merchant, Roger M Jones
Publikováno v:
Journal of Radiation Research. 64:547-557
The pBR322 plasmid DNA was irradiated with 35 MeV electrons, 228 MeV protons and 300 kVp X-rays to quantify DNA damage and make comparisons of DNA damage between radiation modalities. Plasmid was irradiated in a medium containing hydroxyl radical sca
Autor:
Nicholas T. Henthorn, Olga Sokol, Marco Durante, Ludovic De Marzi, Frederic Pouzoulet, Justyna Miszczyk, Pawel Olko, Sytze Brandenburg, Marc Jan van Goethem, Lara Barazzuol, Makbule Tambas, Johannes A. Langendijk, Marie Davídková, Vladimír Vondráĉek, Elisabeth Bodenstein, Joerg Pawelke, Antony J. Lomax, Damien C. Weber, Alexandru Dasu, Bo Stenerlöw, Per R. Poulsen, Brita S. Sørensen, Cai Grau, Mateusz K. Sitarz, Anne-Catherine Heuskin, Stephane Lucas, John W. Warmenhoven, Michael J. Merchant, Ran I. Mackay, Karen J. Kirkby
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biologi
Externí odkaz:
https://doaj.org/article/88275246ca1f4bacb94b8d81b66f3077
Autor:
Nicholas T. Henthorn, Lydia L. Gardner, Adam H. Aitkenhead, Benjamin C. Rowland, Jungwook Shin, Edward A.K. Smith, Michael J. Merchant, Ranald I. Mackay, Karen J. Kirkby, Pankaj Chaudhary, Kevin M. Prise, Stephen J. McMahon, Tracy S.A. Underwood
Publikováno v:
International Journal of Radiation Oncology
Autor:
Charlotte J Heaven, Hannah C Wanstall, Nicholas T Henthorn, John-William Warmenhoven, Samuel P Ingram, Amy L Chadwick, Elham Santina, Jamie Honeychurch, Christine K Schmidt, Karen J Kirkby, Norman F Kirkby, Neil G Burnet, Michael J Merchant
Publikováno v:
Heaven, C J, Wanstall, H C, Henthorn, N T, Warmenhoven, J-W, Ingram, S P, Chadwick, A L, Santina, E, Honeychurch, J, Schmidt, C K, Kirkby, K J, Kirkby, N F, Burnet, N G & Merchant, M J 2022, ' The suitability of micronuclei as markers of relative biological effect ', Mutagenesis, vol. 37, no. 1, pp. 3-12 . https://doi.org/10.1093/mutage/geac001
Mutagenesis
Mutagenesis
Micronucleus (MN) formation is routinely used as a biodosimeter for radiation exposures and has historically been used as a measure of DNA damage in cells. Strongly correlating with dose, MN are also suggested to indicate radiation quality, different
Autor:
Marios, Sotiropoulos, Nicholas T, Henthorn, John W, Warmenhoven, Ranald I, Mackay, Karen J, Kirkby, Michael J, Merchant
Publikováno v:
Nanoscale. 9(46)
Gold nanoparticles have been proven as potential radiosensitizer when combined with protons. Initially the radiosensitization effect was attributed to the physical interactions of radiation with the gold and the production of secondary electrons that