Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nicholas T, Lam"'
Autor:
Nicholas T. Lam, Ngoc Uyen Nhi Nguyen, Mahmoud Salama Ahmed, Ching-Cheng Hsu, Pamela E. Rios Coronado, Shujuan Li, Ivan Menendez-Montes, Suwannee Thet, Waleed M. Elhelaly, Feng Xiao, Xiaoyu Wang, Noelle S. Williams, Diana C. Canseco, Kristy Red-Horse, Beverly A. Rothermel, Hesham A. Sadek
Publikováno v:
Nature Cardiovascular Research. 1:679-688
Autor:
Chukwuemeka George Anene-Nzelu, Michael Kinter, Hesham A. Sadek, Jainy J. Savla, Salim Abdisalaam, Luke I. Szweda, Abdallah Elnwasany, Roger Foo, Ursa Bezan Petric, Ana Helena Macedo Pereira, Ivan Menendez-Montes, Mohammed Kanchwala, Chalermchai Khemtong, Yuji Nakada, Wilson Lek Wen Tan, Shujuan Li, Craig R. Malloy, Mahmoud S. Ahmed, Kaitlyn M. Eckert, Ngoc Uyen Nhi Nguyen, A. Dean Sherry, Emily L Ensley, Aroumougame Asaithamby, Gaurav Sharma, Gonçalo Vale, Chao Xing, Linzhang Huang, Matthew A. Mitsche, Nicholas T. Lam, Philip W. Shaul, Alisson C. Cardoso, Joseph A. Hill, Waleed M. Elhelaly, Jeffrey G. McDonald
Publikováno v:
Nature Metabolism. 2:167-178
The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the first week of life, which coincides with a postnatal shift from anaerobic glycolysis to mitochondri
Autor:
Ivan Menendez-Montes, Zhaoning Wang, Alisson C. Cardoso, Andrew Lemoff, Miao Cui, Mohammad Goodarzi, John M. Shelton, Ngoc Uyen Nhi Nguyen, Ana Helena Macedo Pereira, Shujuan Li, Shah R. Ali, Feng Xiao, Waleed M. Elhelaly, Nicholas T. Lam, Abdallah Elnwasany, Michael Kinter, Hesham A. Sadek, Wataru Kimura, Suwannee Thet, Luke I. Szweda
To identify non-cell-autonomous effectors of cardiomyocyte mitosis, we analyzed a transcriptomic screen of regenerating and non-regenerating neonatal hearts for differentially-expressed secreted proteins – which we hypothesized could include candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::868ea862c7969bb49863246fb5285e55
https://doi.org/10.1101/2021.09.16.460522
https://doi.org/10.1101/2021.09.16.460522
Autor:
Nicholas T. Lam, Hesham A. Sadek, Salim Abdisalaam, Shibani Mukherjee, Aroumougame Asaithamby, Ivan Menendez-Montes, Feng Xiao, Luke I. Szweda
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The inability of adult mammalian cardiomyocytes to proliferate underpins the development of heart failure following myocardial injury. Although the newborn mammalian heart can spontaneously regenerate for a short period of time after birth, this abil
Autor:
David Williams, Kylie M Venardos, Melissa Byrne, Mandar Joshi, Duncan Horlock, Nicholas T Lam, Paul Gregorevic, Sean L McGee, David M Kaye
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104643 (2014)
BackgroundImpaired mitochondrial function is fundamental feature of heart failure (HF) and myocardial ischemia. In addition to the effects of heightened oxidative stress, altered nitric oxide (NO) metabolism, generated by a mitochondrial NO synthase,
Externí odkaz:
https://doaj.org/article/f11909e9fbd049feb59ddde30b0a8a64
Autor:
Chao Xing, Ping Wang, Diana C. Canseco, Ngoc Uyen Nhi Nguyen, Nicholas T. Lam, Shujuan Li, Feng Xiao, Suwannee Thet, Roger J. Hajjar, Mohammed Kanchwala, Xiang Luo, Wataru Kimura, Rohit Singh, Hesham A. Sadek, Waleed M. Elhelaly, Sakthivel Sadayappan, Joseph A. Hill
Recent interest in understanding cardiomyocyte cell-cycle has been driven by potential therapeutic applications in cardiomyopathy. However, despite recent advances, cardiomyocyte mitosis remains a poorly understood process. For example, it is unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d5368f8399f352c0fa872368a46028f
https://doi.org/10.1101/2020.12.24.424022
https://doi.org/10.1101/2020.12.24.424022
Autor:
Tanya L Medley, Milena Furtado, Nicholas T Lam, Rejhan Idrizi, David Williams, Paul J Verma, Mauro Costa, David M Kaye
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80280 (2013)
BackgroundDisturbances in oxygen levels have been found to impair cardiac organogenesis. It is known that stem cells and differentiating cells may respond variably to hypoxic conditions, whereby hypoxia may enhance stem cell pluripotency, while diffe
Externí odkaz:
https://doaj.org/article/31b2bbdba9884fb7b07f61bcbf04b3ec
Autor:
Roy Jagoree, Maimon E. Hubbi, Nicholas T. Lam, Shalini Muralidhar, Shujuan Li, Zhaoning Wang, Roger Foo, Wilson Lek Wen Tan, Beverly A. Rothermel, Jainy J. Savla, Ngoc Uyen Nhi Nguyen, Waleed M. Elhelaly, Diana C. Canseco, Suwannee Thet, Joseph A. Hill, Yuji Nakada, Shah R. Ali, Elisa Villalobos, Chukwuemeka George Anene-Nzelu, Mahmoud S. Ahmed, Feng Xiao, Jesung Moon, Hesham A. Sadek, Ivan Menendez-Montes, Martha S. Cyert
Publikováno v:
Circulation Research. 127
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. Our group recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury throu
Autor:
Alisson C, Cardoso, Nicholas T, Lam, Jainy J, Savla, Yuji, Nakada, Ana Helena M, Pereira, Abdallah, Elnwasany, Ivan, Menendez-Montes, Emily L, Ensley, Ursa Bezan, Petric, Gaurav, Sharma, A Dean, Sherry, Craig R, Malloy, Chalermchai, Khemtong, Michael T, Kinter, Wilson Lek Wen, Tan, Chukwuemeka George, Anene-Nzelu, Roger Sik-Yin, Foo, Ngoc Uyen Nhi, Nguyen, Shujuan, Li, Mahmoud Salama, Ahmed, Waleed M, Elhelaly, Salim, Abdisalaam, Aroumougame, Asaithamby, Chao, Xing, Mohammed, Kanchwala, Goncalo, Vale, Kaitlyn M, Eckert, Matthew A, Mitsche, Jeffrey G, McDonald, Joseph A, Hill, Linzhang, Huang, Philip W, Shaul, Luke I, Szweda, Hesham A, Sadek
Publikováno v:
Nature metabolism
The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the first week of life, which coincides with a postnatal shift from anaerobic glycolysis to mitochondri
Autor:
Shalini Muralidhar, Martha S. Cyert, Jainy J. Savla, Shujuan Li, Jagoree Roy, Yuji Nakada, Maimon E. Hubbi, Beverly A. Rothermel, Roger Foo, Shah R. Ali, Wilson Lek Wen Tan, Mahmoud S. Ahmed, Feng Xiao, Jesung Moon, Kareem A. Zidan, Magid S. Mohamed, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Hesham A. Sadek, Diana C. Canseco, Victoria Le, Chukwuemeka George Anene-Nzelu, Xun Meng, Suwannee Thet, Mohammed Kanchwala, Elisa Villalobos, Nicholas T. Lam, Chao Xing, Joseph A. Hill, Waleed M. Elhelaly, Zhaoning Wang, Victor Le, Hamed W. El-Feky
Publikováno v:
Nguyen, N U N, Canseco, D C, Xiao, F, Nakada, Y, Li, S, Lam, N T, Muralidhar, S A, Savla, J J, Hill, J A, Le, V, Zidan, K A, El-feky, H W, Wang, Z, Ahmed, M S, Hubbi, M E, Menendez-montes, I, Moon, J, Ali, S R, Le, V, Villalobos, E, Mohamed, M S, Elhelaly, W M, Thet, S, Anene-nzelu, C G, Tan, W L W, Foo, R S, Meng, X, Kanchwala, M, Xing, C, Roy, J, Cyert, M S, Rothermel, B A & Sadek, H A 2020, ' A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes ', Nature, vol. 582, no. 7811, pp. 271-276 . https://doi.org/10.1038/s41586-020-2228-6
Nature
Nature
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159c9a7761d7e144ce14b016c92808b2
https://www.pure.ed.ac.uk/ws/files/155195562/ppnature17051.pdf
https://www.pure.ed.ac.uk/ws/files/155195562/ppnature17051.pdf