Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nicholas Suen"'
Autor:
Mehaben Patel, Yorick Post, Natalie Hill, Asmiti Sura, Jay Ye, Trevor Fisher, Nicholas Suen, Mengrui Zhang, Leona Cheng, Ariel Pribluda, Hui Chen, Wen-Chen Yeh, Yang Li, Hélène Baribault, Russell B. Fletcher
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human diseases such as idio
Externí odkaz:
https://doaj.org/article/f27d31a51f9a492fa22352567892c341
Autor:
Parthasarathy Sampathkumar, Heekyung Jung, Hui Chen, Zhengjian Zhang, Nicholas Suen, Yiran Yang, Zhong Huang, Tom Lopez, Robert Benisch, Sung-Jin Lee, Jay Ye, Wen-Chen Yeh, Yang Li
Publikováno v:
eLife, Vol 13 (2024)
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti-ASGR1 a
Externí odkaz:
https://doaj.org/article/a9f6fd6b3417451d9b40177a6d13884a
Autor:
Hui Chen, Sung-Jin Lee, Ryan Li, Asmiti Sura, Nicholas Suen, Archana Dilip, Yan Pomogov, Meghah Vuppalapaty, Timothy T Suen, Chenggang Lu, Yorick Post, Yang Li
Publikováno v:
eLife, Vol 12 (2024)
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we have termed
Externí odkaz:
https://doaj.org/article/b18a4fedb9594fe39bd8ab03b0fe2af9
Autor:
Huy, Nguyen, Hui, Chen, Meghah, Vuppalapaty, Elizabeth, Whisler, Kelsey Ronarda, Logas, Parthasarathy, Sampathkumar, Russell Byron, Fletcher, Asmiti, Sura, Nicholas, Suen, Suhani, Gupta, Tom, Lopez, Jay, Ye, Shengjiang, Tu, Menaka, Bolaki, Wen-Chen, Yeh, Yang, Li, Sung-Jin, Lee
Publikováno v:
Translational Vision Science & Technology. 11:19
There remains a high unmet need for therapies with new mechanisms of action to achieve reperfusion of ischemic retina in diabetic retinopathy. We examined whether a novel frizzled class receptor 4 (FZD4) agonist could promote regeneration of function