Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nicholas Spellmon"'
Autor:
Nicholas Spellmon, Artur Muszyński, Ireneusz Górniak, Jiri Vlach, David Hahn, Parastoo Azadi, Jochen Zimmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gram negative microbes strategically equip lipopolysaccharides with O antigens to expand the extracellular envelope. Here, the authors examine how the O antigen is captured by a special class of ABC transporters containing a carbohydrate-binding modu
Externí odkaz:
https://doaj.org/article/f351dd5029a24ec6aa893c69d590cdab
Publikováno v:
AIMS Biophysics, Vol 4, Iss 4, Pp 557-575 (2017)
To date, X-ray crystallography remains the gold standard for the determination of macromolecular structure and protein substrate interactions. However, the unpredictability of obtaining a protein crystal remains the limiting factor and continues to b
Externí odkaz:
https://doaj.org/article/df4af2053005419cbe6ee1f0528ab46e
Autor:
Nicholas Spellmon, Xiaonan Sun, Wen Xue, Joshua Holcomb, Srinivas Chakravarthy, Weifeng Shang, Brian Edwards, Nualpun Sirinupong, Chunying Li, Zhe Yang
Publikováno v:
AIMS Biophysics, Vol 4, Iss 1, Pp 1-18 (2016)
SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in
Externí odkaz:
https://doaj.org/article/0dd7be38221c45bea0461db5c912b8c3
Publikováno v:
AIMS Biophysics, Vol 3, Iss 4, Pp 450-455 (2016)
Externí odkaz:
https://doaj.org/article/048c389625f44eb0a81f7f76a7aae4ef
Autor:
Joshua Holcomb, Maysaa Doughan, Nicholas Spellmon, Brianne Lewis, Emerson Perry, Yingxue Zhang, Lindsey Nico, Junmei Wan, Srinivas Chakravarthy, Weifeng Shang, Qing Miao, Timothy Stemmler, Zhe Yang
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191371 (2018)
The Nogo-B receptor (NgBR) is involved in oncogenic Ras signaling through directly binding to farnesylated Ras. It recruits farnesylated Ras to the non-lipid-raft membrane for interaction with downstream effectors. However, the cytosolic domain of Ng
Externí odkaz:
https://doaj.org/article/0d670d4ba5bf484b825e3347043161db
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145758 (2015)
SMYD proteins are an exciting field of study as they are linked to many types of cancer-related pathways. Cardiac and skeletal muscle development and function also depend on SMYD proteins opening a possible avenue for cardiac-related treatment. Previ
Externí odkaz:
https://doaj.org/article/2ab6e32050cd4f43a3c0a5507791a6b3
Autor:
Stephanie Hayden, Kaitlyn Martin, Nicholas Spellmon, Kendall M. Muzzarelli, Zhe Yang, Ladislau C. Kovari, Wen Xue, Yingxue Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 550:1-7
Studying thermal stability of proteins not only provides insight into protein structure but also is instrumental in identifying previously unknown interaction partners. We develop a machine learning strategy that combines orthogonal partial least squ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b47a318b11e0ddb95b1c516d6d278f
https://doi.org/10.1016/j.bbrc.2021.02.073
https://doi.org/10.1016/j.bbrc.2021.02.073
Publikováno v:
Annual Review of Biochemistry. 89:741-768
Complex carbohydrates are essential for many biological processes, from protein quality control to cell recognition, energy storage, and cell wall formation. Many of these processes are performed in topologically extracellular compartments or on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e714151e65ebcf603738e2499db67c58
https://doi.org/10.1146/annurev-biochem-011520-104707
https://doi.org/10.1146/annurev-biochem-011520-104707
Autor:
Shaoman Zhou, Franck Amblard, Peng Liu, Zhe Yang, Iulia A. Kovari, Ladislau C. Kovari, Justin Hackett, Nicholas Spellmon, Raymond F. Schinazi, Benjamin D. Kuiper, Joseph S. Brunzelle, Kendall M. Muzzarelli
Publikováno v:
Biochemistry
Norovirus is the leading cause of acute gastroenteritis worldwide with a yearly reported 700 million cases driving a $60 billion global socioeconomic burden. With no United States Food and Drug Administration approved therapeutics and the chance for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bce1cc9516236e879fe619c50d5e2c
https://doi.org/10.1021/acs.biochem.8b01063
https://doi.org/10.1021/acs.biochem.8b01063
Autor:
Fatme Hachem, Vishakha Choudhary, Yingxue Zhang, Joshua Holcomb, Junmei Wan, Joseph S. Brunzelle, Andrea Niu, Maysaa Doughan, Nicholas Spellmon, Stephanie Hayden, Zhe Yang, Chunying Li, Xiaonan Sun
Publikováno v:
Biochemical and Biophysical Research Communications. 485:529-534
The CXC chemokine receptor 2 (CXCR2) is a G protein coupled receptor mediating interleukin-8 chemotactic signaling and plays an important role in neutrophil mobility and tumor migration. However, efficient CXCR2 signaling requires PDZ domain-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d26fd8cc5633ee27a93543c0fa1700
https://doi.org/10.1016/j.bbrc.2017.02.010
https://doi.org/10.1016/j.bbrc.2017.02.010