Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nicholas Smithers"'
Autor:
Gemma D. Banham, Colin Y. C. Lee, John R. Ferdinand, Rebeccah J. Matthews, Chenzhi Jing, Nicholas Smithers, Rab K. Prinjha, Menna R. Clatworthy
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to widespread changes i
Externí odkaz:
https://doaj.org/article/e322c97f57e446f2ad778535777f905e
Autor:
Valentina S. Caputo, Nikolaos Trasanidis, Xiaolin Xiao, Mark E. Robinson, Alexia Katsarou, Kanagaraju Ponnusamy, Rab K. Prinjha, Nicholas Smithers, Aristeidis Chaidos, Holger W. Auner, Anastasios Karadimitris
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101989- (2021)
Summary: Osteoclast (OC) development in response to nuclear factor kappa-Β ligand (RANKL) is critical for bone homeostasis in health and in disease. The early and direct chromatin regulatory changes imparted by the BET chromatin readers Brd2-4 and O
Externí odkaz:
https://doaj.org/article/5937c26f23c24a70a47ad818b646ebb2
Autor:
Clovis Chabert, Saadi Khochbin, Sophie Rousseaux, Sylvie Veyrenc, Rebecca Furze, Nicholas Smithers, Rab K Prinjha, Uwe Schlattner, Christophe Pison, Hervé Dubouchaud
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2224 (2018)
Pulmonary hypertension is a co-morbidity, which strongly participates in morbi-mortality in patients with chronic obstructive pulmonary disease (COPD). Recent findings showed that bromodomain-containing proteins, in charge of reading histone acetylat
Externí odkaz:
https://doaj.org/article/c6d7b4acb2e44b78ba31a86adb7e1fc9
Autor:
Jude Alsarraj, Farhoud Faraji, Thomas R Geiger, Katherine R Mattaini, Mia Williams, Josephine Wu, Ngoc-Han Ha, Tyler Merlino, Renard C Walker, Allen D Bosley, Zhen Xiao, Thorkell Andresson, Dominic Esposito, Nicholas Smithers, Dave Lugo, Rab Prinjha, Anup Day, Nigel P S Crawford, Keiko Ozato, Kevin Gardner, Kent W Hunter
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80746 (2013)
Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases. BRD4, a target of BET inhibitors, encodes two isofo
Externí odkaz:
https://doaj.org/article/c2c9aa744b3a4146a566e38515814caa
Data from Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL
Autor:
Gianni Cazzaniga, Andrea Biondi, Rob Pieters, Ronald W. Stam, Giuseppe Basso, Geertruy Te Kronnie, Rab K. Prinjha, Nicholas Smithers, Mark Kerstjens, Eddy H.J. Van Roon, Grazia Fazio, Patricia Garrido Castro, Angela M. Savino, Margherita Vieri, Francesca Rizzo, Luca Trentin, Michela Bardini
MLL-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis. Despite the development of specific therapeutic protocols, infant patients with MLL-rearrange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f58741275371233589698b39895095
https://doi.org/10.1158/1535-7163.c.6539490
https://doi.org/10.1158/1535-7163.c.6539490
Autor:
Gianni Cazzaniga, Andrea Biondi, Rob Pieters, Ronald W. Stam, Giuseppe Basso, Geertruy Te Kronnie, Rab K. Prinjha, Nicholas Smithers, Mark Kerstjens, Eddy H.J. Van Roon, Grazia Fazio, Patricia Garrido Castro, Angela M. Savino, Margherita Vieri, Francesca Rizzo, Luca Trentin, Michela Bardini
Supplementary Methods: provide additional information about the methods used in the present study; Supplementary Figure S1: refers to apoptosis analysis of patients-derived xenograft samples exposed to IBET151 ex vivo; Supplementary Figure S2: report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839d380f218b8fadea99c5caa872c7fc
https://doi.org/10.1158/1535-7163.22510059
https://doi.org/10.1158/1535-7163.22510059
Autor:
John Toubia, Hannah McCalmont, Debora A. Casolari, Chelsea Mayoh, Saumya E. Samaraweera, Richard J D'Andrea, Sarah C Bray, Ka Leung Li, Ian D. Lewis, Rab K. Prinjha, Nicholas Smithers, Luke Jones, Shudong Wang, Richard B. Lock
Publikováno v:
Blood Advances. 4:296-300
Chromosomal rearrangements of the lysine methyltransferase 2A (KMT2A or MLL) gene are observed in ;10% of all acute leukemias, with particularly high frequency (;80%) in infant acute lymphoblastic leukemia (ALL),1 where, despite aggressive chemothera
Autor:
Trees Jansen, Rab K. Prinjha, Anaísa V Ferreira, Rebecca C. Furze, Nicholas Smithers, Mihai G. Netea, Jorge Domínguez-Andrés
Publikováno v:
European Journal of Immunology, 49, 2044-2050
European Journal of Immunology, 49, 11, pp. 2044-2050
European Journal of Immunology
European Journal of Immunology, 49, 11, pp. 2044-2050
European Journal of Immunology
Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in i
Autor:
Mark Robinson, Anastasios Karadimitris, Alexia Katsarou, Xiaolin Xiao, Kanagaraju Ponnusamy, Valentina S. Caputo, Aristeidis Chaidos, Holger W. Auner, Nicholas Smithers, Rab K. Prinjha, Nikolaos Trasanidis
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101989-(2021)
iScience
iScience
Summary Osteoclast (OC) development in response to nuclear factor kappa-Β ligand (RANKL) is critical for bone homeostasis in health and in disease. The early and direct chromatin regulatory changes imparted by the BET chromatin readers Brd2-4 and OC
Autor:
Ronald W. Stam, Grazia Fazio, Giovanni Cazzaniga, Angela Maria Savino, Geertruy te Kronnie, Patricia Garrido Castro, Francesca Rizzo, Eddy H.J. van Roon, Andrea Biondi, Mark Kerstjens, Luca Trentin, Margherita Vieri, Michela Bardini, Rab K. Prinjha, Giuseppe Basso, Nicholas Smithers, Rob Pieters
Publikováno v:
Molecular Cancer Therapeutics, 17(8), 1705-1716. American Association for Cancer Research Inc.
MLL-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis. Despite the development of specific therapeutic protocols, infant patients with MLL-rearrange