Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Nicholas Schwab"'
Autor:
Valerie E. Teschner, Ann-Katrin Fleck, Carolin Walter, Anna-Sophie Schwarze, Melanie Eschborn, Timo Wirth, Olga V. Steinberg, Andreas Schulte-Mecklenbeck, I-Na Lu, Marisol Herrera-Rivero, Claudia Janoschka, Jan D. Lünemann, Nicholas Schwab, Gerd Meyer zu Hörste, Julian Varghese, Catharina C. Gross, Refik Pul, Christoph Kleinschnitz, Simone Mader, Edgar Meinl, Monika Stoll, Heinz Wiendl, Luisa Klotz
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background: Cladribine is a highly effective immunotherapy that is applied in two short-term courses over 2 years and reduces relapse rate and disease progression in patients with relapsing multiple sclerosis (MS). Despite the short treatment period,
Externí odkaz:
https://doaj.org/article/620f3b4ae03d47ceb2b1381faa850bb4
Autor:
Eli Hatchwell, Edward B. Smith, Shapour Jalilzadeh, Christopher D. Bruno, Yassine Taoufik, Houria Hendel-Chavez, Roland Liblau, David Brassat, Guillaume Martin-Blondel, Heinz Wiendl, Nicholas Schwab, Irene Cortese, Maria Chiara Monaco, Luisa Imberti, Ruggero Capra, Jorge R. Oksenberg, Jacques Gasnault, Bruno Stankoff, Todd A. Richmond, David M. Rancour, Igor J. Koralnik, Barbara A. Hanson, Eugene O. Major, Christina R. Chow, Peggy S. Eis
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundProgressive multifocal leukoencephalopathy (PML) is a rare and often lethal brain disorder caused by the common, typically benign polyomavirus 2, also known as JC virus (JCV). In a small percentage of immunosuppressed individuals, JCV is re
Externí odkaz:
https://doaj.org/article/1490902a359c49238be460026325caaf
Autor:
Catharina C. Gross, Céline Meyer, Urvashi Bhatia, Lidia Yshii, Ilka Kleffner, Jan Bauer, Anna R. Tröscher, Andreas Schulte-Mecklenbeck, Sebastian Herich, Tilman Schneider-Hohendorf, Henrike Plate, Tanja Kuhlmann, Markus Schwaninger, Wolfgang Brück, Marc Pawlitzki, David-Axel Laplaud, Delphine Loussouarn, John Parratt, Michael Barnett, Michael E. Buckland, Todd A. Hardy, Stephen W. Reddel, Marius Ringelstein, Jan Dörr, Brigitte Wildemann, Markus Kraemer, Hans Lassmann, Romana Höftberger, Eduardo Beltrán, Klaus Dornmair, Nicholas Schwab, Luisa Klotz, Sven G. Meuth, Guillaume Martin-Blondel, Heinz Wiendl, Roland Liblau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model,
Externí odkaz:
https://doaj.org/article/4c98395f104445a7a39848447428e6cc
Autor:
Jan Thompson, Baskar Ganapathysubramanian, Wei Chen, Michael Dorneich, Philip Gassman, Caroline Krejci, Matthew Liebman, Ajay Nair, Ulrike Passe, Nicholas Schwab, Kurt Rosentrater, Tiffanie Stone, Yiming Wang, Yuyu Zhou
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
Most people in the world live in urban areas, and their high population densities, heavy reliance on external sources of food, energy, and water, and disproportionately large waste production result in severe and cumulative negative environmental eff
Externí odkaz:
https://doaj.org/article/5baee25854ea43ffa63c47c287a9cfa7
Autor:
Tim Sinnecker, Jeffrie Hadisurya, Tilman Schneider-Hohendorf, Nicholas Schwab, Karsten Wrede, Oliver Gembruch, Ralf Gold, Kerstin Hellwig, Sara Pilgram-Pastor, Ortwin Adams, Philipp Albrecht, Hans-Peter Hartung, Orhan Aktas, Markus Kraemer
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-6 (2019)
Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinu
Externí odkaz:
https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1
Autor:
Ramy A. Arnaout, Eline T. Luning Prak, Nicholas Schwab, Florian Rubelt, the Adaptive Immune Receptor Repertoire Community, Rohit Arora, Rachael Bashford-Rogers, Felix Breden, Syed Ahmad Chan Bukhari, Brian Corrie, Lindsay G. Cowell, Sol Efroni, Christopher Gooley, Victor Greiff, Jason Vander Heiden, Yoshinobu Koguchi, Ton Langerak, Theam Soon Lim, Eline Luning Prak, Encarnita Mariotti-Ferrandiz, Susanna Marquez, Pieter Meysman, Enkelejda Miho, Keshav Motwani, Nima Nouri, Milena Pavlović, Geir Kjetil Sandve, Igor Snapkov, Cinque Soto, Ulrik Stervbo, Johannes Trück, Henk-Jan van den Ham, Corey Watson, Cédric R. Weber
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
It is increasingly clear that an extraordinarily diverse range of clinically important conditions—including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers—leave telltale signatures in the mil
Externí odkaz:
https://doaj.org/article/722776cd07cd4898b11d91fbcc3ffabd
Autor:
Lisa Zondler, Sebastian Herich, Petra Kotte, Katharina Körner, Tilman Schneider-Hohendorf, Heinz Wiendl, Nicholas Schwab, Alexander Zarbock
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and caus
Externí odkaz:
https://doaj.org/article/48f05921969d47bbb25f27ee3c4a33d6
Autor:
Johanna Breuer, Eva Korpos, Melanie-Jane Hannocks, Tilman Schneider-Hohendorf, Jian Song, Lisa Zondler, Sebastian Herich, Ken Flanagan, Thomas Korn, Alexander Zarbock, Tanja Kuhlmann, Lydia Sorokin, Heinz Wiendl, Nicholas Schwab
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Very late antigen 4 (VLA-4; integrin α4β1) is critical for transmigration of T helper (TH) 1 cells into the central nervous system (CNS) under inflammatory conditions such as multiple sclerosis (MS). We have previously shown tha
Externí odkaz:
https://doaj.org/article/ad681e70065a4e31ad301967c1b2efd7
Autor:
Luisa Klotz, Joachim Havla, Nicholas Schwab, Reinhard Hohlfeld, Michael Barnett, Stephen Reddel, Heinz Wiendl
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
In recent years, there has been a paradigm shift in the treatment of multiple sclerosis (MS) owing to the approval of a number of new drugs with very distinct mechanisms of action. All approved disease-modifying drugs primarily work directly on the i
Externí odkaz:
https://doaj.org/article/577600add0b04a2ab82a8172d5d0f004
Autor:
Tilman Schneider-Hohendorf, Hema Mohan, Christian G. Bien, Johanna Breuer, Albert Becker, Dennis Görlich, Tanja Kuhlmann, Guido Widman, Sebastian Herich, Christiane Elpers, Nico Melzer, Klaus Dornmair, Gerhard Kurlemann, Heinz Wiendl, Nicholas Schwab
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Rasmussen Encephalitis is a rare neurological disease accompanied by inflammation and T cell infiltration in the brain. Here the authors show that the severity of this disease correlates with clonal CD8 T cell expansion.
Externí odkaz:
https://doaj.org/article/628a86018f024cc3bd4d4ee72d33b5f0