Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Nicholas S. Tolwinski"'
Autor:
Nicholas S. Tolwinski
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 2, p 15 (2024)
In this Special Issue, titled “Drosophila—A Model System for Developmental Biology”, we present a series of articles and reviews looking at the diverse ways that researchers are using the humble fruit fly, also known as the vinegar fly, to tack
Externí odkaz:
https://doaj.org/article/d10b57d4ba1f44318814118bb90a0076
Autor:
Qian Hui Tan, Agimaa Otgonbaatar, Prameet Kaur, Angelica Faye Ga, Nathan P. Harmston, Nicholas S. Tolwinski
Publikováno v:
Cells, Vol 13, Iss 5, p 365 (2024)
Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes i
Externí odkaz:
https://doaj.org/article/0468d6e6377a4462942f40399028c691
Autor:
Jay B. Lusk, Ellora Hui Zhen Chua, Prameet Kaur, Isabelle Chiao Han Sung, Wen Kin Lim, Vanessa Yuk Man Lam, Nathan Harmston, Nicholas S. Tolwinski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Proper embryonic development requires directional axes to pattern cells into embryonic structures. In Drosophila, spatially discrete expression of transcription factors determines the anterior to posterior organization of the early embryo, w
Externí odkaz:
https://doaj.org/article/dfb761956de44fe5ad80f4623742e7b2
Autor:
Prabhat Tiwari, Nicholas S. Tolwinski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4300 (2023)
Across the world a dementia case is diagnosed every three seconds. Alzheimer’s disease (AD) causes 50–60% of these cases. The most prominent theory for AD correlates the deposition of amyloid beta (Aβ) with the onset of dementia. Whether Aβ is
Externí odkaz:
https://doaj.org/article/c83b052322414229a8c9837093c867e4
Autor:
Prameet Kaur, Ellora Hui Zhen Chua, Wen Kin Lim, Jiarui Liu, Nathan Harmston, Nicholas S. Tolwinski
Publikováno v:
Cells, Vol 11, Iss 2, p 281 (2022)
Patients with Alzheimer’s disease suffer from a decrease in brain mass and a prevalence of amyloid-β plaques. These plaques are thought to play a role in disease progression, but their exact role is not entirely established. We developed an optoge
Externí odkaz:
https://doaj.org/article/8b64a16f5e3e4962a0df8a123b0e5647
Autor:
Prameet Kaur, Vanessa Yuk Man Lam, Anirudh Gautam Mannava, Jahnavi Suresh, Andreas Jenny, Nicholas S. Tolwinski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during cano
Externí odkaz:
https://doaj.org/article/f0b54aded1a04e80b4c93f85536b5bf0
Autor:
Eungi Yang, Ofelia Tacchelly-Benites, Zhenghan Wang, Michael P. Randall, Ai Tian, Hassina Benchabane, Sarah Freemantle, Claudio Pikielny, Nicholas S. Tolwinski, Ethan Lee, Yashi Ahmed
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling
Externí odkaz:
https://doaj.org/article/3da63aa64149454db576577367439463
Autor:
Li Fang Ng, Prameet Kaur, Nawat Bunnag, Jahnavi Suresh, Isabelle Chiao Han Sung, Qian Hui Tan, Jan Gruber, Nicholas S. Tolwinski
Publikováno v:
Cells, Vol 8, Iss 8, p 826 (2019)
Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide ran
Externí odkaz:
https://doaj.org/article/074c049b19b44f2cbb64b04a02cf007a
Publikováno v:
Genes, Vol 9, Iss 2, p 101 (2018)
The discovery of induced pluripotent stem (iPS) cells, barely more than a decade ago, dramatically transformed the study of stem cells and introduced a completely new way to approach many human health concerns. Although advances have pushed the field
Externí odkaz:
https://doaj.org/article/36fe6bb93356496290df0d27d98719bf
Autor:
Nicholas S. Tolwinski
Publikováno v:
Journal of Developmental Biology, Vol 5, Iss 3, p 9 (2017)
Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used model organisms for biomedical science.[...]
Externí odkaz:
https://doaj.org/article/6be66956f23b4c159291e576939dbd91