Výsledky vyhledávání - "Nicholas S. R. Sanderson"

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

Autor: Martin Diebold, Edoardo Galli, Andreas Kopf, Nicholas S R Sanderson, Ilaria Callegari, Pascal Benkert, Nicolás Gonzalo Núñez, Florian Ingelfinger, Stefan Herms, Sven Cichon, Ludwig Kappos, Jens Kuhle, Burkhard Becher, Manfred Claassen, Tobias Derfuss

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 119(31), e2205042119 (2022). doi:10.1073/pnas.2205042119
Proceedings of the National Academy of Sciences of the United States of America, 119 (31)

Dimethyl fumarate (DMF) is an immunomodulatory treatment for multiple sclerosis (MS). Despite its wide clinical use, the mechanisms underlying clinical response are not understood. This study aimed to reveal immune markers of therapeutic response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d26ff76a23541494dfbb780996c6108
https://doi.org/10.1073/pnas.2205042119

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Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities

Autor: Natalie Rose, Sebastian Holdermann, Ilaria Callegari, Hyein Kim, Isabelle Fruh, Ludwig Kappos, Jens Kuhle, Matthias Müller, Nicholas S. R. Sanderson, Tobias Derfuss

Publikováno v: Acta neuropathologica. 144(5)

Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the neuromuscular junction (NMJ). The most common autoantibody target is the acetylcholine receptor (AChR). Three m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d5bb6a417f9e7ecd1a267567a5ad12
https://pubmed.ncbi.nlm.nih.gov/36074148

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Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch

Autor: Ilaria Callegari, Mika Schneider, Giuliano Berloffa, Tobias Mühlethaler, Sebastian Holdermann, Edoardo Galli, Tim Roloff, Renate Boss, Laura Infanti, Nina Khanna, Adrian Egli, Andreas Buser, Gert Zimmer, Tobias Derfuss, Nicholas S R Sanderson

Publikováno v: Callegari, Ilaria; Schneider, Mika; Berloffa, Giuliano; Mühlethaler, Tobias; Holdermann, Sebastian; Galli, Edoardo; Roloff, Tim; Boss, Renate; Infanti, Laura; Khanna, Nina; Egli, Adrian; Buser, Andreas; Zimmer, Gert; Derfuss, Tobias; Sanderson, Nicholas S R (2022). Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch. EMBO reports, 23(7), e53956. EMBO press 10.15252/embr.202153956

To investigate the class-dependent properties of anti-viral IgM antibodies, we use membrane antigen capture activated cell sorting to isolate spike-protein-specific B cells from donors recently infected with SARS-CoV-2, allowing production of recombi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8deff3b366d2a75cb1f6bcdd9e36e97
https://pubmed.ncbi.nlm.nih.gov/35548920

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Mass Cytometry of CSF Identifies an MS-Associated B-cell Population

Autor: Camille Regairaz, Guglielmo Roma, Jens Kuhle, Martin Diebold, José M. Carballido, Layla Raad, Ilaria Callegari, Annick Waldt, Julien Roux, Rachel Cuttat, Edoardo Galli, Tobias Derfuss, Nicholas S. R. Sanderson, Céline Rauld, Burkhard Becher, David Johansson

Publikováno v: Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3

ObjectiveTo identify an MS-specific immune cell population by deep immune phenotyping and relate it to soluble signaling molecules in CSF.MethodsWe analyzed surface expression of 22 markers in paired blood/CSF samples from 39 patients using mass cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8c0b6a79a07ff26a6bbf5872eaf8b1
https://pubmed.ncbi.nlm.nih.gov/33589541

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Akademický článek

Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain.

Autor: Mariana Puntel, Robert Barrett, Nicholas S R Sanderson, Kurt M Kroeger, Niyati Bondale, Mia Wibowo, Sean Kennedy, Chunyan Liu, Maria G Castro, Pedro R Lowenstein

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23523 (2011)

CD8(+) T cells infiltrate the brain during an anti-viral immune response. Within the brain CD8(+) T cells recognize cells expressing target antigens, become activated, and secrete IFNγ. However, there are no methods to recognize individual cells tha

Externí odkaz: https://doaj.org/article/56d63cd621844155953612e6ed9b7931

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Akademický článek

T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.

Autor: Carlos Barcia, Nicholas S R Sanderson, Robert J Barrett, Kolja Wawrowsky, Kurt M Kroeger, Mariana Puntel, Chunyan Liu, Maria G Castro, Pedro R Lowenstein

Publikováno v: PLoS ONE, Vol 3, Iss 8, p e2977 (2008)

Astrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T cells is poorly understood. Effector T cells establish specific contacts with target cells, kn

Externí odkaz: https://doaj.org/article/b5648ab732a5454e9e7696deb81e3252

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Cocapture of cognate and bystander antigens can activate autoreactive B cells

Autor: Raija L.P. Lindberg, Stephanie K. Dougan, Hidde L. Ploegh, Luca Eilinger, Celine Gubser, Ludwig Kappos, Tobias Derfuss, Maria Zimmermann, Nicholas S. R. Sanderson, Nicole Schaeren-Wiemers

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated encephalomyelitis (ADEM). For ADEM, it is speculated that a preceding infection is the trigger of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486d5c5a136452bf3ab349870b36fa79
https://doi.org/10.1073/pnas.1614472114

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GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis

Autor: Manfred Claassen, Nicholas S. R. Sanderson, Eirini Arvaniti, Felix J. Hartmann, Martin Diebold, Burkhard Becher, Mohsen Khademi, Fredrik Piehl, Dunja Mrdjen, Tobias Derfuss, Edoardo Galli, Tomas Olsson, Christine Stadelmann, Faiez Al Nimer, Carsten Krieg, Bettina Schreiner, Franziska van der Meer, Florian Ingelfinger

Publikováno v: Nature Medicine, 25 (8)
Nature medicine

Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine polarization profile in patients with relapsing-remitting multiple scle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a434cdccc36318aa14dc13a933c6c7
https://pubmed.ncbi.nlm.nih.gov/31358988

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B Cells and Autoantibodies in Multiple Sclerosis

Autor: Tobias Derfuss, Nicholas S. R. Sanderson, Anne-Katrin Pröbstel

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 16576-16592 (2015)
International Journal of Molecular Sciences

While over the past decades T cells have been considered key players in the pathogenesis of multiple sclerosis (MS), it has only recently become evident that B cells have a major contributing role. Our understanding of the role of B cells has evolved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c989ed81ad9a50ab6779c1bacd9036de
http://www.mdpi.com/1422-0067/16/7/16576

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