Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nicholas S. Heaton"'
Autor:
Samantha Skavicus, Nicholas S. Heaton
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Externí odkaz:
https://doaj.org/article/7493513197e842a48f69114077d077e7
Autor:
Joseph D. Trimarco, Sarah L. Nelson, Ryan R. Chaparian, Alexandra I. Wells, Nathan B. Murray, Parastoo Azadi, Carolyn B. Coyne, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of host antiviral restriction factors could provide targets for antiviral therapy. Here, using a genome-wide CRISPR screen, the authors identify the glycosyltransferase B3GAT1 as a host protein which, when ectopically overexpressed, re
Externí odkaz:
https://doaj.org/article/421acf3c2de24f58bda9a6d24454f5bd
Autor:
Rebekah E. Dumm, Jessica K. Fiege, Barbara M. Waring, Chay T. Kuo, Ryan A. Langlois, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Infection of a cell with influenza B virus (IBV) often results in cell death and the role of surviving cells in pathogenesis is unclear. Here, Dumm et al. generate a recombinant IBV that activates a host-cell reporter to permanently label infected ce
Externí odkaz:
https://doaj.org/article/9031272241854e39a95eb61c490bdf38
Autor:
Alfred T. Harding, Nicholas S. Heaton
Publikováno v:
Cancers, Vol 14, Iss 4, p 909 (2022)
Sex hormones, such as estrogen and testosterone, are steroid compounds with well-characterized effects on the coordination and development of vertebrate reproductive systems. Since their discovery, however, it has become clear that these “sex hormo
Externí odkaz:
https://doaj.org/article/1e328cb3883a4159a6f7cddbdbde6004
Autor:
Brook E. Heaton, Edward M. Kennedy, Rebekah E. Dumm, Alfred T. Harding, Matthew T. Sacco, David Sachs, Nicholas S. Heaton
Publikováno v:
Cell Reports, Vol 20, Iss 7, Pp 1503-1512 (2017)
Influenza A virus (IAV) is a pathogen that poses significant risks to human health. It is therefore critical to develop strategies to prevent influenza disease. Many loss-of-function screens have been performed to identify the host proteins required
Externí odkaz:
https://doaj.org/article/e716c767ea214b789a87a430cce058b3
Autor:
Benjamin O. Fulton, David Sachs, Shannon M. Beaty, Sohui T. Won, Benhur Lee, Peter Palese, Nicholas S. Heaton
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1331-1338 (2015)
Measles virus undergoes error-prone replication like other RNA viruses, but over time, it has remained antigenically monotypic. The constraints on the virus that prevent the emergence of antigenic variants are unclear. As a first step in understandin
Externí odkaz:
https://doaj.org/article/572093e3f28746d19e5c05d542a4dbdd
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. To facilitate cost-effective growth, vaccine strains are serially passaged under production conditio
Externí odkaz:
https://doaj.org/article/903553c0d64a420585785726adc1a281
Autor:
Rebekah E. Dumm, Nicholas S. Heaton
Publikováno v:
Viruses, Vol 11, Iss 8, p 736 (2019)
Influenza B viruses (IBVs) are major contributors to total human influenza disease, responsible for ~1/3 of all infections. These viruses, however, are relatively less studied than the related influenza A viruses (IAVs). While it has historically bee
Externí odkaz:
https://doaj.org/article/6fbdbcf077584f8988c9f57564746b95
Autor:
Nicholas S. Heaton, Glenn Randall
Publikováno v:
Viruses, Vol 3, Iss 8, Pp 1332-1341 (2011)
Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM
Externí odkaz:
https://doaj.org/article/35d5fab0771b44cd98a8f77fda5a7849
Autor:
Alfred T. Harding, Nicholas S. Heaton
Publikováno v:
Vaccines, Vol 6, Iss 2, p 19 (2018)
Influenza viruses infect approximately 20% of the global population annually, resulting in hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) approved antiviral drugs for combating the disease, vaccination remains the
Externí odkaz:
https://doaj.org/article/f2363fc00f7b48ef821d2b6dc30e1f75