Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas S. Giacobbi"'
Publikováno v:
Viruses, Vol 16, Iss 2, p 302 (2024)
There is great enthusiasm toward the development of novel immunotherapies for the treatment of cancer, and given their roles in immune system regulation, chemokines stand out as promising candidates for use in new cancer therapies. Many previous stud
Externí odkaz:
https://doaj.org/article/7d41231be88b48e3abc4019653d00370
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008814 (2020)
Externí odkaz:
https://doaj.org/article/f85fea7f68004657ba36f04c967fe0e6
Autor:
Nicolas Sluis Cremer, Ryan L. Slack, Rieko Ishima, Gota Kawai, Nicholas S. Giacobbi, Tatiana V Ilina, Michael A. Parniak, Stefan G. Sarafianos, Zhaoyong Xi
Publikováno v:
Structure
HIV-1 reverse transcriptase (RT) is translated as part of the Gag-Pol polyprotein that is proteolytically processed by HIV-1 protease (PR) to finally become a mature heterodimer, composed of a p66 and a p66-derived 51 kDa subunit, p51. Our prior work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62907cae452de16bc31fd72ee6465e5
https://pubmed.ncbi.nlm.nih.gov/31471129
https://pubmed.ncbi.nlm.nih.gov/31471129
Autor:
Phalguni Gupta, Narasimhan J. Venkatachari, Feng Han, Nicholas S. Giacobbi, Nicolas Sluis-Cremer, Benni Vargas, Anwesha Sanyal
Signaling pathways play a key role in HIV-1 latency. In this study, we used the 24ST1NLESG cell line of HIV-1 latency to screen a library of structurally diverse, medicinally active, cell permeable kinase inhibitors, which target a wide range of sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92ee024163fe8dfacd0eb4883784919
https://europepmc.org/articles/PMC6355603/
https://europepmc.org/articles/PMC6355603/
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 9, p e1008814 (2020)
PLoS Pathogens, Vol 16, Iss 9, p e1008814 (2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e235cc21e5143b864eec703073654d94
https://doi.org/10.1371/journal.ppat.1008814
https://doi.org/10.1371/journal.ppat.1008814
Autor:
Thomas J. Smith, Peter Thielen, Naiwen Cui, Adrian W.R. Serohijos, Nicholas S. Giacobbi, James M. Pipas, Jeffrey S. Lin, Susan Wu, Jeong-Mo Choi, Thomas Mehoke, Hua Zhang, David A. Weitz, Lloyd W. Ung, Ye Tao, Audrey Fischer, João V. Rodrigues, Joshua T. Wolfe, Andrew B. Feldman, Eugene I. Shakhnovich, Abimbola O. Kolawole, Connie B. Chang, Stephan A. Koehler, Plamen A. Demirev, Kellogg J. Schwab, Timothy R. Julian, Assaf Rotem, Christiane E. Wobus
Publikováno v:
Molecular Biology and Evolution
Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive. Here, we apply a biophysical fitness mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0f479e2ee679ad27ce0dc79d5630c0
https://pubmed.ncbi.nlm.nih.gov/29955873
https://pubmed.ncbi.nlm.nih.gov/29955873
Publikováno v:
Virology. 476:377-385
Ectopic expression of Simian Virus 40 (SV40) large T antigen (LT) in mouse embryonic fibroblasts (MEFs) increased levels of mRNAs encoding interferon stimulated genes (ISGs). The mechanism by which T antigen increases levels of ISGs in MEFs remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e420a2532b11429878f84d71ca9996f
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Rilpivirine (RPV), dapivirine (DPV), and MIV-150 are in development as microbicides. It is not known whether they will block infection of circulating nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant human immunodeficiency virus type 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b48edae2af63edb20fe3aff4fac8a4
https://doi.org/10.1128/aac.00277-17
https://doi.org/10.1128/aac.00277-17
Autor:
Ming Ding, Jennifer M. Zerbato, Bruce K. Patterson, Nicolas Sluis-Cremer, Phalguni Gupta, Anwesha Sanyal, Amanda Chargin, Narasimhan J. Venkatachari, Nicholas S. Giacobbi, Deena Ratner, Yue Chen, Charles R. Rinaldo, Robbie B. Mailliard
Publikováno v:
Nature medicine
Although antiretroviral therapy can suppress HIV-1 infection to undetectable levels of plasma viremia, integrated latent HIV-1 genomes that encode replication competent virus persist in resting CD4+ T cells. This latent HIV-1 reservoir represents a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8defba603aaed24ef140385c7e540b66
https://pubmed.ncbi.nlm.nih.gov/28553933
https://pubmed.ncbi.nlm.nih.gov/28553933
Autor:
James M. Pipas, Saumendra N. Sarkar, Nicholas S. Giacobbi, Christopher J. Bakkenist, Adriana Forero, Ole Gjoerup, Kevin D. McCormick
Publikováno v:
The Journal of Immunology
Polyomaviruses encode a large T Ag (LT), a multifunctional protein essential for the regulation of both viral and host cell gene expression and productive viral infection. Previously, we have shown that stable expression of LT protein results in upre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b3ea11fb1a05852610067aa0cfd0d3
https://doi.org/10.4049/jimmunol.1303470
https://doi.org/10.4049/jimmunol.1303470