Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Nicholas S. Caron"'
Autor:
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials. Sensiti
Externí odkaz:
https://doaj.org/article/89b2e043ae1a4ef094cfbb9512ed2741
Autor:
Paweł Joachimiak, Adam Ciesiołka, Emilia Kozłowska, Paweł M. Świtoński, Grzegorz Figura, Agata Ciołak, Grażyna Adamek, Magdalena Surdyka, Żaneta Kalinowska-Pośka, Maciej Figiel, Nicholas S. Caron, Michael R. Hayden, Agnieszka Fiszer
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The majority of genes in the human genome is present in two copies but the expression levels of both alleles is not equal. Allelic imbalance is an aspect of gene expression relevant not only in the context of genetic variation, bu
Externí odkaz:
https://doaj.org/article/b4208318decb46dc9b945542e1422b52
Autor:
Siddharth Nath, Nicholas S. Caron, Linda May, Oxana B. Gluscencova, Jill Kolesar, Lauren Brady, Brett A. Kaufman, Gabrielle L. Boulianne, Amadeo R. Rodriguez, Mark A. Tarnopolsky, Ray Truant
Publikováno v:
Human Genome Variation, Vol 9, Iss 1, Pp 1-12 (2022)
Neurodegenerative disease: Finding new mutations associated with ataxia Two genetic mutations combine to cause a novel variant of spinocerebellar ataxia (SCA), a rare neurodegenerative disease. SCA affects the cerebellum, a brain region that controls
Externí odkaz:
https://doaj.org/article/3daafa26d2c04bf0a4a4c5ae75472e88
Autor:
Nicholas S. Caron, Raul Banos, Amirah E. Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M. Anderson, Benjamin Gordon, Amber L. Southwell, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 166, Iss , Pp 105652- (2022)
Huntington disease (HD) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the HTT gene encoding an elongated polyglutamine tract in the huntingtin (HTT) protein. Expanded mutant HTT (mHTT) is toxic and leads to regional atr
Externí odkaz:
https://doaj.org/article/60744919d1f14be893b4b7443dbd2e49
Autor:
Fanny L. Lemarié, Nicholas S. Caron, Shaun S. Sanders, Mandi E. Schmidt, Yen T.N. Nguyen, Seunghyun Ko, Xiaohong Xu, Mahmoud A. Pouladi, Dale D.O. Martin, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105479- (2021)
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. HTT is subject to multiple post-translational modifications (PTMs) that
Externí odkaz:
https://doaj.org/article/2444a423afaf47e1a97c55c90c9868f3
Autor:
Mandi E. Schmidt, Nicholas S. Caron, Amirah E. Aly, Fanny L. Lemarié, Louisa Dal Cengio, Yun Ko, Nikola Lazic, Lisa Anderson, Betty Nguyen, Lynn A. Raymond, Michael R. Hayden
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Huntington disease (HD) is a devastating neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Disrupted cortico-striatal transmission is an early event that contributes to neuronal spine and synapse dysfunction primaril
Externí odkaz:
https://doaj.org/article/b4cb13fb61c5467bbd2761b7d6e1c14c
Autor:
Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates
Externí odkaz:
https://doaj.org/article/927e14de01344da3b997cbcf2b24e178
Autor:
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi, Michael R. Hayden
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo load
Externí odkaz:
https://doaj.org/article/3098d7176f61480fbe25947e9399afed
Autor:
Magdalena Surdyka, Anna Niewiadomska-Cimicka, Zaneta Kalinowska-Poska, Ewelina Jesion, Elisabeth Singer-Mikosch, Lorraine Fievet, Agnieszka Fiszer, Nicholas S Caron, Michael R Hayden, Huu Phuc Nguyen, Yvon Trottier, Maciej Figiel
Publikováno v:
I: Experimental therapeutics – preclinical.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb81ee75aae73da402ff9063015ba9d
https://doi.org/10.1136/jnnp-2022-ehdn.229
https://doi.org/10.1136/jnnp-2022-ehdn.229
Autor:
Nicholas S Caron, Arsalan S Haqqani, Akshdeep Sandhu, Amirah E Aly, Hailey Findlay Black, Jeffrey N Bone, Jodi L McBride, Abedelnasser Abulrob, Danica Stanimirovic, Blair R Leavitt, Michael R Hayden
Publikováno v:
D: Wet biomarkers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac93dea464c3251027ccc73e5851d63
https://doi.org/10.1136/jnnp-2022-ehdn.72
https://doi.org/10.1136/jnnp-2022-ehdn.72