Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nicholas S Wilson"'
Autor:
Randi B Gombos, Ana Gonzalez, Mariana Manrique, Dhan Chand, David Savitsky, Benjamin Morin, Ekaterina Breous-Nystrom, Christopher Dupont, Rebecca A Ward, Cornelia Mundt, Benjamin Duckless, Hao Tang, Mark A Findeis, Andrea Schuster, Jeremy D Waight, Dennis Underwood, Christopher Clarke, Gerd Ritter, Taha Merghoub, David Schaer, Jedd D Wolchok, Marc van Dijk, Jennifer S Buell, Jean-Marie Cuillerot, Robert Stein, Elise E Drouin, Nicholas S Wilson
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety o
Externí odkaz:
https://doaj.org/article/a2c5e638342c4ecea28b08aa00701413
Autor:
Marilyn Marques, Nicholas S. Wilson, Sylvia Dietrich, Jennifer Buell, Jeremy D. Waight, Rebecca Ward, Elena Paltrinieri, Dhan Chand, David Savitsky, Mark Bushell, Priyadarshini Iyer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an important negative regulator of the immune response to cancer that contributes to resistance/relapse to anti-PD-1 therapy.1 In clinical trials, anti-human (h) TIGIT antibodies ha
Autor:
Nicholas S. Wilson, Dhan Chand, Min Lim, Dennis J. Underwood, Anthony W. Tolcher, Irina M. Shapiro, Anna Wijatyk, Mark Findeis, David Savitsky, Richard D. Carvajal, Jennifer Buell, Vignesh Venkatraman, Lernik Ohanjanian, James Strauss, Marc Van Dijk, Marilyn Marques, Claire Galand, Olga Ignatovich, Benjamin Morin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background CD137 (4-1BB) represents a costimulatory pathway that promotes T, NK, and dendritic cell effector functions favorable for antitumor immunity. The extracellular domain of CD137, comprised of four cysteine-rich domains (CRD-I, CRD-II, CRD-II
Publikováno v:
Pattern Recognition. 124:108444
This paper presents a new approach to a robust Gaussian process regression, creating a non-parametric Bayesian regression estimate robust to outliers. Most existing approaches replace an outlier-prone Gaussian likelihood with a non-Gaussian likelihoo
Publikováno v:
Human Antibodies. 25:87-109
Co-stimulatory tumor necrosis factor receptors (TNFRs) can sculpt the responsiveness of T cells recognizing tumor-associated antigens. For this reason, agonist antibodies targeting CD137, CD357, CD134 and CD27 have received considerable attention for
Autor:
Dhan Chand, Benjamin Morin, Jennifer Buell, Ekaterina Breous-Nystrom, Jeremy D. Waight, Jedd D. Wolchok, Taha Merghoub, Elise Drouin, Nicholas S. Wilson, Christopher Clarke, Marc Van Dijk, Christopher D. Dupont, Cornelia Anne Mundt, David Savitsky, Andrea Schuster, Mark Findeis, Dennis J. Underwood, Benjamin Duckless, Mariana Manrique, Rebecca Ward, Gerd Ritter, Randi Gombos, Ana M. Martín González, Robert Stein, Jean Marie Cuillerot, Hao Tang, David Schaer
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)
PLoS ONE
PLoS ONE
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety o
Autor:
Kin-Ming Lo, Nicholas S. Wilson, Kenneth W. Hance, Robert Tighe, Helen Sabzevari, Robert Hofmeister, Yan Lan, Dong Zhang, Jeremy D. Waight, Shinji Takai, Guozhong Qin, Bo Marelli
Publikováno v:
The Journal of Immunology. 194:878-882
CD4+ regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad
Autor:
Nicholas S. Wilson, Sylvia Dietrich, Randi Gombos, Ana M. Martín González, Robert Stein, Lukasz Swiech, David Savitsky, Ben A. Croker, Benjamin Morin, Jennifer Buell, Mariana Manrique, Antoine Tanne, Jeremy D. Waight, Christine Brittsan, Dhan Chand, Belinda Akpeng, Thomas Horn
Publikováno v:
Cancer cell. 33(6)
Summary The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to therapeutic activity has been extensively studied. For example, F
Autor:
Randi Gombos, David Savitsky, Mark Bushell, Mathew Costa, Nicholas S. Wilson, R.B. Stein, Sylvia Dietrich, Jennifer Buell, Jeremy D. Waight, Elena Paltrinieri, Alexander Duncan, Dhan Chand
Publikováno v:
Cancer Research. 79:2390-2390
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) has emerged as an important regulator of the cancer-immunity cycle. Preclinical studies have demonstrated that TIGIT antibodies can enhance T and NK cell anti-tumor immunity, and therapeutic anti
Autor:
Randi Gombos, Matthew Costa, Claire Galand, Nicholas S. Wilson, Olga Ignatovich, Cailin E. Joyce, Dennis J. Underwood, David Savitsky, Benjamin Morin, Vignesh Venkatraman, Cornelia Anne Mundt, Min Lim, Christina Riordan, R.B. Stein, Rebecca M. Ward, Yanping Xiao, Dhan Chand, Mark Findeis, Marc van Dijk
Publikováno v:
Journal of Clinical Oncology. 37:e14005-e14005
e14005 Background: Agonist antibodies targeting CD137 are potent inducers of tumor-reactive T cell proliferation, cytokine production, and cytotoxicity, and have been explored clinically for their ability to enhance immune cell-mediated destruction o