Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Nicholas S Kirkby"'
Autor:
Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183025 (2017)
RationaleNitric oxide synthase (NOS) is a biomarker/target in sepsis. NOS activity is driven by amino acids, which cycle to regulate the substrate L-arginine in parallel with cycles which regulate the endogenous inhibitors ADMA and L-NMMA. The relati
Externí odkaz:
https://doaj.org/article/2e318961191b4024bb0cead40dbb6561
Autor:
Blerina Ahmetaj-Shala, Michael Olanipekun, Abel Tesfai, Niall MacCallum, Nicholas S. Kirkby, Gregory J. Quinlan, Chih-Chin Shih, Ryota Kawai, Sharon Mumby, Mark Paul-Clark, Elizabeth J. Want, Jane A. Mitchell
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Externí odkaz:
https://doaj.org/article/9334704285f14cf0b336bf208608e733
Autor:
Nicholas S Kirkby, Martina H Lundberg, William R Wright, Timothy D Warner, Mark J Paul-Clark, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98165 (2014)
Cyxlo-oxygenase (COX)-2 inhibitors, including traditional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with increased cardiovascular side effects, including myocardial infarction. We and others have shown that COX-1 and not COX-2 driv
Externí odkaz:
https://doaj.org/article/496c671654e540fda0ae65c895136f06
Autor:
Nicholas S Kirkby, Anne K Zaiss, Paula Urquhart, Jing Jiao, Philip J Austin, Malak Al-Yamani, Martina H Lundberg, Louise S MacKenzie, Timothy D Warner, Anna Nicolaou, Harvey R Herschman, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69524 (2013)
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found
Externí odkaz:
https://doaj.org/article/18a323ab2fc043b0bc1ea6141626660a
Autor:
Nicholas S Kirkby, Lucinda Low, Jonathan R Seckl, Brian R Walker, David J Webb, Patrick W F Hadoke
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16906 (2011)
Traditional methods for the analysis of vascular lesion formation are labour intensive to perform - restricting study to 'snapshots' within each vessel. This study was undertaken to determine the suitability of optical projection tomographic (OPT) im
Externí odkaz:
https://doaj.org/article/d4557a34f95449bdad14ae337ad6f065
Autor:
Paul C Armstrong, Nicholas S Kirkby, Zetty N Zain, Michael Emerson, Jane A Mitchell, Timothy D Warner
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20062 (2011)
Clinical use of selective inhibitors of cyclooxygenase (COX)-2 appears associated with increased risk of thrombotic events. This is often hypothesised to reflect reduction in anti-thrombotic prostanoids, notably PGI(2), formed by COX-2 present within
Externí odkaz:
https://doaj.org/article/320c554b0ecb41e6b4fd249643787c65
Autor:
Aleksandra Judina, Marili Niglas, Vladislav Leonov, Nicholas S. Kirkby, Ivan Diakonov, Peter T. Wright, Lan Zhao, Jane A. Mitchell, Julia Gorelik
Publikováno v:
Cells, Vol 12, Iss 23, p 2764 (2023)
(1) Pulmonary hypertension (PH)-associated right ventricular (RV) failure is linked to a reduction in pulmonary vasodilators. Treprostinil has shown effectiveness in PAH patients with cardiac decompensation, hinting at potential cardiac benefits. We
Externí odkaz:
https://doaj.org/article/d9c9e0ef31eb4ac383dcf8f7feb383b1
Autor:
Plinio Ferreira, Ricky Vaja, Maria Lopes-Pires, Marilena Crescente, He Yu, Rolf Nüsing, Bin Liu, Yingbi Zhou, Magdi Yaqoob, Anran Zhang, Matthew Rickman, Hilary Longhurst, William E. White, Rebecca B. Knowles, Melissa V. Chan, Timothy D. Warner, Elizabeth Want, Nicholas S. Kirkby, Jane A. Mitchell
Publikováno v:
Kidney International Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ffa11fbc9dc27c26fba23518a6a5216
https://doi.org/10.1016/j.ekir.2023.03.014
https://doi.org/10.1016/j.ekir.2023.03.014
Autor:
Nicholas S. Kirkby, Ivana Vojnovic, Chih-Chin Shih, Paul C Armstrong, Timothy D. Warner, Jane A. Mitchell, Melissa V. Chan
Publikováno v:
British Journal of Pharmacology. 178:4758-4771
Background and purpose P2Y12 receptor antagonists reduce platelet aggregation and the incidence of arterial thrombosis. Adenosine signalling in platelets directly affects cyclic nucleotide tone, which we have shown to have a synergistic relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a522c92df209f90db68b251cf039ef48
https://doi.org/10.1111/bph.15659
https://doi.org/10.1111/bph.15659
Autor:
Paul C. Armstrong, Harriet E. Allan, Nicholas S. Kirkby, Clemens Gutmann, Abhishek Joshi, Marilena Crescente, Jane A. Mitchell, Manuel Mayr, Timothy D. Warner
Publikováno v:
Blood advances. 6(23)
The proportion of young platelets, also known as newly formed or reticulated, within the overall platelet population has been clinically correlated with adverse cardiovascular outcomes. However, our understanding of this is incomplete because of limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cf0ebd02f00248aa0c47922b385ef8
https://pubmed.ncbi.nlm.nih.gov/36037520
https://pubmed.ncbi.nlm.nih.gov/36037520