Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nicholas S Heaton"'
Autor:
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012345 (2024)
The CRISPR-Cas13 system has been proposed as an alternative treatment of viral infections. However, for this approach to be adopted as an antiviral, it must be optimized until levels of efficacy rival or exceed the performance of conventional approac
Externí odkaz:
https://doaj.org/article/ff2b71e5f2c14cc889ed30f7de84cd2e
Autor:
David J Bacsik, Bernadeta Dadonaite, Andrew Butler, Allison J Greaney, Nicholas S Heaton, Jesse D Bloom
Publikováno v:
eLife, Vol 12 (2023)
The ultimate success of a viral infection at the cellular level is determined by the number of progeny virions produced. However, most single-cell studies of infection quantify the expression of viral transcripts and proteins, rather than the amount
Externí odkaz:
https://doaj.org/article/9127c1486737475b8b8868e7d39955cd
Autor:
Heather M Froggatt, Kaitlyn N Burke, Ryan R Chaparian, Hector A Miranda, Xinyu Zhu, Benjamin S Chambers, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009951 (2021)
Influenza A viruses encode their genomes across eight, negative sense RNA segments. The six largest segments produce mRNA transcripts that do not generally splice; however, the two smallest segments are actively spliced to produce the essential viral
Externí odkaz:
https://doaj.org/article/5f9db5129dae43e99d5e7c7d6e8b2e01
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.
Autor:
Joseph D Trimarco, Brook E Heaton, Ryan R Chaparian, Kaitlyn N Burke, Raquel A Binder, Gregory C Gray, Clare M Smith, Vineet D Menachery, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009599 (2021)
Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt to complete
Externí odkaz:
https://doaj.org/article/485cd3cfaf524a5b9fa4517614d1a44a
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008098 (2019)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting virion incompletely infectious. It is kn
Externí odkaz:
https://doaj.org/article/e46eed4b7dda409aba017274b569886d
Autor:
Jessica K Fiege, Ian A Stone, Rebekah E Dumm, Barbara M Waring, Brian T Fife, Judith Agudo, Brian D Brown, Nicholas S Heaton, Ryan A Langlois
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008077 (2019)
Influenza A virus (IAV) is a seasonal pathogen with the potential to cause devastating pandemics. IAV infects multiple epithelial cell subsets in the respiratory tract, eliciting damage to the lungs. Clearance of IAV is primarily dependent on CD8+ T
Externí odkaz:
https://doaj.org/article/3abedd6189e14d2cba46d2013be0f6b3
Autor:
Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006409 (2017)
Externí odkaz:
https://doaj.org/article/81405dd53c8a448ea872d93c35e5a4a7
Autor:
Yi-ying Chou, Nicholas S Heaton, Qinshan Gao, Peter Palese, Robert H Singer, Timothée Lionnet
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003358 (2013)
The Influenza A virus genome consists of eight negative sense, single-stranded RNA segments. Although it has been established that most virus particles contain a single copy of each of the eight viral RNAs, the packaging selection mechanism remains p
Externí odkaz:
https://doaj.org/article/149978ab166748f8804a936920f5f9cd
Autor:
Kelly E Coller, Nicholas S Heaton, Kristi L Berger, Jacob D Cooper, Jessica L Saunders, Glenn Randall
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002466 (2012)
The current model of hepatitis C virus (HCV) production involves the assembly of virions on or near the surface of lipid droplets, envelopment at the ER in association with components of VLDL synthesis, and egress via the secretory pathway. However,
Externí odkaz:
https://doaj.org/article/917a3506af76443d9e8ed8c77fb39025
Publikováno v:
PLoS Pathogens, Vol 5, Iss 12, p e1000702 (2009)
Hepatitis C virus (HCV) enters hepatocytes following a complex set of receptor interactions, culminating in internalization via clathrin-mediated endocytosis. However, aside from receptors, little is known about the cellular molecular requirements fo
Externí odkaz:
https://doaj.org/article/31e686d87fbb4d0696bd63a2d6d46f6f