Development and validation of a prognostic 40-day mortality risk model among hospitalized patients with COVID-19.

Autor: Donald A Berry, Andrew Ip, Brett E Lewis, Scott M Berry, Nicholas S Berry, Mary MrKulic, Virginia Gadalla, Burcu Sat, Kristen Wright, Michelle Serna, Rashmi Unawane, Katerina Trpeski, Michael Koropsak, Puneet Kaur, Zachary Sica, Andrew McConnell, Urszula Bednarz, Michael Marafelias, Andre H Goy, Andrew L Pecora, Ihor S Sawczuk, Stuart L Goldberg

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0255228 (2021)

ObjectivesThe development of a prognostic mortality risk model for hospitalized COVID-19 patients may facilitate patient treatment planning, comparisons of therapeutic strategies, and public health preparations.MethodsWe retrospectively reviewed the

Externí odkaz: https://doaj.org/article/0544c34f8de74d10831452a6e428d4c2

The Bayesian Time Machine: Accounting for temporal drift in multi-arm platform trials

Autor: Benjamin R Saville, Donald A Berry, Nicholas S Berry, Kert Viele, Scott M Berry

Publikováno v: Clinical Trials. 19:490-501

Background Multi-arm platform trials investigate multiple agents simultaneously, typically with staggered entry and exit of experimental treatment arms versus a shared control arm. In such settings, there is considerable debate whether to limit analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5831411c632d5a9e43812efae32223fb
https://doi.org/10.1177/17407745221112013

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC) : an open-label, platform-adaptive randomised controlled trial

Autor: Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, Najib M Rahman, Gail Hayward, Duncan B Richards, Jienchi Dorward, David M Lowe, Joseph F Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S Nguyen-Van-Tam, Mahendra G Patel, Benjamin R Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P B Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A Detry, Christina T Saunders, Mark Fitzgerald, Nicholas S Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D Jani, Nigel D Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little, Akosua A Agyeman, Tanveer Ahmed, Damien Allcock, Adrian Beltran-Martinez, Oluseye E Benedict, Nigel Bird, Laura Brennan, Julianne Brown, Gerard Burns, Mike Butler, Zelda Cheng, Ruth Danson, Nigel de Kare-Silver, Devesh Dhasmana, Jon Dickson, Serge Engamba, Stacey Fisher, Robin Fox, Eve Frost, Richard Gaunt, Sarit Ghosh, Ishtiaq Gilkar, Anna Goodman, Steve Granier, Aleksandra Howell, Iqbal Hussain, Simon Hutchinson, Marie Imlach, Greg Irving, Nicholas Jacobsen, James Kennard, Umar Khan, Kyle Knox, Christopher Krasucki, Tom Law, Rem Lee, Nicola Lester, David Lewis, James Lunn, Claire I. Mackintosh, Mehul Mathukia, Patrick Moore, Seb Morton, Daniel Murphy, Rhiannon Nally, Chinonso Ndukauba, Olufunto Ogundapo, Henry Okeke, Amit Patel, Kavil Patel, Ruth Penfold, Satveer Poonian, Olajide Popoola, Alexander Pora, Vibhore Prasad, Rishabh Prasad, Omair Razzaq, Scot Richardson, Simon Royal, Afsana Safa, Satash Sehdev, Tamsin Sevenoaks, Divya Shah, Aadil Sheikh, Vanessa Short, Baljinder S Sidhu, Ivor Singh, Yusuf Soni, Chris Thalasselis, Pete Wilson, David Wingfield, Michael Wong, Maximillian N J Woodall, Nick Wooding, Sharon Woods, Joanna Yong, Francis Yongblah, Azhar Zafar

Publikováno v: PANORAMIC Trial Collaborative Group, Butler, C C, Hobbs, F D R, Gbinigie, O A, Rahman, N M, Hayward, G, Richards, D B, Dorward, J, Lowe, D M, Standing, J F, Breuer, J, Khoo, S, Petrou, S, Hood, K, Nguyen-Van-Tam, J S, Patel, M G, Saville, B R, Marion, J, Ogburn, E, Allen, J, Rutter, H, Francis, N, Thomas, N P B, Evans, P, Dobson, M, Madden, T-A, Holmes, J, Harris, V, Png, M E, Lown, M, van Hecke, O, Detry, M A, Saunders, C T, Fitzgerald, M, Berry, N S, Mwandigha, L, Galal, U, Mort, S, Jani, B D, Hart, N D, Ahmed, H, Butler, D, McKenna, M, Chalk, J, Lavallee, L, Hadley, E, Cureton, L, Benysek, M, Andersson, M, Coates, M & Barrett, S 2023, ' Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial ', The Lancet, vol. 401, no. 10373, pp. 281-293 . https://doi.org/10.1016/S0140-6736(22)02597-1

Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6937dbf90341fd2ff687fe41c3d612
https://hdl.handle.net/10023/27412

A clustering method for graphical handwriting components and statistical writership analysis

Autor: Nicholas S. Berry, Alicia L. Carriquiry, Amy Crawford

Publikováno v: Statistical Analysis and Data Mining

Handwritten documents can be characterized by their content or by the shape of the written characters. We focus on the problem of comparing a person's handwriting to a document of unknown provenance using the shape of the writing, as is done in foren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6cd6ac6672ffe5aac4ea4a92997d2b
https://doi.org/10.1002/sam.11488

Hydroxychloroquine and tocilizumab therapy in COVID-19 patients-An observational study

Autor: Andre Goy, Joseph P. Underwood, Ihor S. Sawczuk, Noa Biran, Andrew Ip, Eric Hansen, Brittany A Sinclaire, Arif Asif, Steven J. Sperber, Stuart L. Goldberg, Lisa Tank, Keith M. Rose, Donald A. Berry, Jerry Zuckerman, Andrew L. Pecora, Nicholas S. Berry, Carol L. Barsky, Sarah L. Timmapuri, Joseph Landolfi, Rani Sebti, Gregory Sugalski, Jason Korcak, Urszula Bednarz, Daniel W. Varga, Cristina Cicogna, Shivam Mathura, Bindu Balani, Scott M. Berry, Michael Marafelias, Laurie G Jacobs, Ronaldo C. Go, Julia A. Piwoz

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237693 (2020)
PLOS ONE, 15(8):e0237693
BASE-Bielefeld Academic Search Engine
PLoS ONE

BackgroundHydroxychloroquine has been touted as a COVID-19 treatment. Tocilizumab, an inhibitor of IL-6, has been proposed as a treatment of critically ill patients.ObjectiveTo describe the association between mortality and hydroxychloroquine or toci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07e4ecb39cdbd57862707ca89b6d077
https://doaj.org/article/0eb4769173b44ac7b0878cbcbb1584b3