Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Nicholas S, Tolwinski"'
Autor:
Nicholas S. Tolwinski
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 2, p 15 (2024)
In this Special Issue, titled “Drosophila—A Model System for Developmental Biology”, we present a series of articles and reviews looking at the diverse ways that researchers are using the humble fruit fly, also known as the vinegar fly, to tack
Externí odkaz:
https://doaj.org/article/d10b57d4ba1f44318814118bb90a0076
Autor:
Qian Hui Tan, Agimaa Otgonbaatar, Prameet Kaur, Angelica Faye Ga, Nathan P. Harmston, Nicholas S. Tolwinski
Publikováno v:
Cells, Vol 13, Iss 5, p 365 (2024)
Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes i
Externí odkaz:
https://doaj.org/article/0468d6e6377a4462942f40399028c691
Autor:
Jay B. Lusk, Ellora Hui Zhen Chua, Prameet Kaur, Isabelle Chiao Han Sung, Wen Kin Lim, Vanessa Yuk Man Lam, Nathan Harmston, Nicholas S. Tolwinski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Proper embryonic development requires directional axes to pattern cells into embryonic structures. In Drosophila, spatially discrete expression of transcription factors determines the anterior to posterior organization of the early embryo, w
Externí odkaz:
https://doaj.org/article/dfb761956de44fe5ad80f4623742e7b2
Publikováno v:
Bio-Protocol, Vol 10, Iss 23 (2020)
Alzheimer’s Disease (AD) has long been associated with accumulation of extracellular amyloid plaques (Aβ) originating from the Amyloid Precursor Protein. Plaques have, however, been discovered in healthy individuals and not all AD brains show plaq
Externí odkaz:
https://doaj.org/article/d7d4e6502ea145e5a652f1a04c47d4ee
Autor:
Chu Hsien Lim, Prameet Kaur, Emelyne Teo, Vanessa Yuk Man Lam, Fangchen Zhu, Caroline Kibat, Jan Gruber, Ajay S Mathuru, Nicholas S Tolwinski
Publikováno v:
eLife, Vol 9 (2020)
The brains of Alzheimer’s disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP). Amy
Externí odkaz:
https://doaj.org/article/92b095df61944eb6979288e58c478d4a
Autor:
Prameet Kaur, Ellora Hui Zhen Chua, Wen Kin Lim, Jiarui Liu, Nathan Harmston, Nicholas S. Tolwinski
Publikováno v:
Cells, Vol 11, Iss 2, p 281 (2022)
Patients with Alzheimer’s disease suffer from a decrease in brain mass and a prevalence of amyloid-β plaques. These plaques are thought to play a role in disease progression, but their exact role is not entirely established. We developed an optoge
Externí odkaz:
https://doaj.org/article/8b64a16f5e3e4962a0df8a123b0e5647
Autor:
Prameet Kaur, Vanessa Yuk Man Lam, Anirudh Gautam Mannava, Jahnavi Suresh, Andreas Jenny, Nicholas S. Tolwinski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during cano
Externí odkaz:
https://doaj.org/article/f0b54aded1a04e80b4c93f85536b5bf0
Autor:
Eungi Yang, Ofelia Tacchelly-Benites, Zhenghan Wang, Michael P. Randall, Ai Tian, Hassina Benchabane, Sarah Freemantle, Claudio Pikielny, Nicholas S. Tolwinski, Ethan Lee, Yashi Ahmed
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling
Externí odkaz:
https://doaj.org/article/3da63aa64149454db576577367439463
Autor:
Prabhat Tiwari, Nicholas S. Tolwinski
Publikováno v:
Opsin-free Optogenetics ISBN: 9781003280750
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::585512e1f56ebf051303ace625056698
https://doi.org/10.1201/b22823-8
https://doi.org/10.1201/b22823-8
Autor:
Lucian B. Tomaz, Bernard A. Liu, null Meroshini M, Sheena L. M. Ong, Ee Kim Tan, Nicholas S. Tolwinski, Christopher S. Williams, Anne-Claude Gingras, Marc Leushacke, N. Ray Dunn
Publikováno v:
Journal of Cell Science. 135
The gene mutated in colorectal cancer (MCC) encodes a coiled-coil protein implicated, as its name suggests, in the pathogenesis of hereditary human colon cancer. To date, however, the contributions of MCC to intestinal homeostasis and disease remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e308d6dc24a6b58e3e28ecc70c80687
https://doi.org/10.1242/jcs.259272
https://doi.org/10.1242/jcs.259272