Zobrazeno 1 - 10
of 635
pro vyhledávání: '"Nicholas S, Hill"'
Autor:
Brianna F. Moon, Iris Y. Zhou, Yingying Ning, Yin‐Ching I. Chen, Mariane Le Fur, Sergey Shuvaev, Eman A. Akam, Hua Ma, Cesar Molinos Solsona, Jonah Weigand‐Whittier, Nicholas Rotile, Lida P. Hariri, Matthew Drummond, Avery T. Boice, Samantha E. Zygmont, Yamini Sharma, Rod R. Warburton, Gregory L. Martin, Robert M. Blanton, Barry L. Fanburg, Nicholas S. Hill, Peter Caravan, Krishna C. Penumatsa
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background Aging‐associated left ventricular dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right ventricular failure. At the time of diagnosis, cardiac function has declined, and cardiopulmonar
Externí odkaz:
https://doaj.org/article/fa3b4d084c534778b2beccd7d0657d41
Autor:
Karen E. A. Burns, Myriam Lafrienier-Roula, Nicholas S. Hill, Deborah J. Cook, Andrew J. E. Seely, Bram Rochwerg, Michael Mayette, Frederick D’Aragon, John W. Devlin, Peter Dodek, Maged Tanios, Audrey Gouskos, Alexis F. Turgeon, Pierre Aslanian, Ying Tung Sia, Jeremy R. Beitler, Robert Hyzy, Gerard J. Criner, Elias Baedorf Kassis, Jennifer L. Y. Tsang, Maureen O. Meade, Janice M. Liebler, Jessica T. Y. Wong, Kevin E. Thorpe, For the Canadian Critical Care Trials Group
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract Background This update summarizes key changes made to the protocol for the Frequency of Screening and Spontaneous Breathing Trial (SBT) Technique Trial—North American Weaning Collaborative (FAST-NAWC) trial since the publication of the ori
Externí odkaz:
https://doaj.org/article/ce791a89f1e2415fafbf3ff1a4952852
Autor:
Krishna C. Penumatsa, Yamini Sharma, Rod R. Warburton, Adit Singhal, Deniz Toksoz, Chinmayee D. Bhedi, Guanming Qi, Ioana R. Preston, Christina Anderlind, Nicholas S. Hill, Barry L. Fanburg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pulmonary hypertension (PH) pathogenesis is driven by inflammatory and metabolic derangements as well as glycolytic reprogramming. Induction of both interleukin 6 (IL6) and transglutaminase 2 (TG2) expression participates in human and experimental ca
Externí odkaz:
https://doaj.org/article/381c17b270eb4d1c8a45c65eadd5697c
Autor:
Tim Raveling, Judith M. Vonk, Nicholas S. Hill, Peter C. Gay, Ciro Casanova, Enrico Clini, Thomas Köhnlein, Eduardo Márquez-Martin, Tessa Schneeberger, Patrick B. Murphy, Fransien M. Struik, Huib A.M. Kerstjens, Marieke L. Duiverman, Peter J. Wijkstra
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Background Not all hypercapnic COPD patients benefit from home noninvasive ventilation (NIV), and mechanisms through which NIV improves clinical outcomes remain uncertain. We aimed to identify “responders” to home NIV, denoted by a beneficial eff
Externí odkaz:
https://doaj.org/article/8d10fde96c9d43b1bdaaa3a90a583d97
Autor:
Hunter Gillies, Murali M. Chakinala, Benjamin T. Dake, Jeremy P. Feldman, Marius M. Hoeper, Marc Humbert, Zhi‐Cheng Jing, Jonathan Langley, Vallerie V. McLaughlin, Ralph W. Niven, Stephan Rosenkranz, Xiaosha Zhang, Nicholas S. Hill
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract AV‐101 (imatinib) powder for inhalation, an investigational dry powder inhaled formulation of imatinib designed to target the underlying pathobiology of pulmonary arterial hypertension, was generally well tolerated in healthy adults in a p
Externí odkaz:
https://doaj.org/article/6cca6181d66a4a5aadc281acfa6b68ed
Autor:
Mario Naranjo, Erika B. Rosenzweig, Anna R. Hemnes, Miriam Jacob, Ankit Desai, Nicholas S. Hill, A. Brett Larive, J. Emanuel Finet, Jane Leopold, Evelyn Horn, Robert Frantz, Franz Rischard, Serpil Erzurum, Gerald Beck, Stephen C. Mathai, Paul M. Hassoun, the PVDOMICS Study Group
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 3, Pp n/a-n/a (2023)
Abstract The prevalence of acute vasodilator response (AVR) to inhaled nitric oxide (iNO) during right heart catheterization (RHC) is 12% in idiopathic pulmonary arterial hypertension (IPAH). AVR, however, is reportedly lower in other disease‐assoc
Externí odkaz:
https://doaj.org/article/13c1a8d9ff844dbdb41fb3812a4d8872
Autor:
Ryan S. Mote, Nicholas S. Hill, Joseph H. Skarlupka, Jessica M. Carpenter, Jeferson M. Lourenco, Todd R. Callaway, ViLinh T. Tran, Ken Liu, Mathew R. Smith, Dean P. Jones, Garret Suen, Nikolay M. Filipov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Bovine fescue toxicosis (FT) is caused by grazing ergot alkaloid-producing endophyte (Epichloë coenophiala)-infected tall fescue. Endophyte’s effects on the animal’s microbiota and metabolism were investigated recently, but its effects
Externí odkaz:
https://doaj.org/article/a7df8a9cebeb468aac6443a66eed55aa
Autor:
Hunter Gillies, Ralph Niven, Benjamin T. Dake, Murali M. Chakinala, Jeremy P. Feldman, Nicholas S. Hill, Marius M. Hoeper, Marc Humbert, Vallerie V. McLaughlin, Martin Kankam
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Oral imatinib has been shown to be effective, but poorly tolerated, in patients with advanced pulmonary arterial hypertension (PAH). To maintain efficacy while improving tolerability, AV-101, a dry powder inhaled formulation of imatinib, w
Externí odkaz:
https://doaj.org/article/6e8ff00f40604cb1bb338a1660e59c87
Autor:
Mihaela S. Stefan, Penelope S. Pekow, Christopher M. Shea, Ashley M. Hughes, Nicholas S. Hill, Jay S. Steingrub, Mary Jo S. Farmer, Dean R. Hess, Karen L. Riska, Taylar A. Clark, Peter K. Lindenauer
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-5 (2021)
Abstract Background There is strong evidence that noninvasive ventilation (NIV) improves the outcomes of patients hospitalized with severe COPD exacerbation, and NIV is recommended as the first-line therapy for these patients. Yet, several studies ha
Externí odkaz:
https://doaj.org/article/635648ba407242f1838e0cacd6e52153
Autor:
Robert P. Frantz, Jane A. Leopold, Paul M. Hassoun, Anna R. Hemnes, Evelyn M. Horn, Stephen C. Mathai, Franz P. Rischard, A. Brett Larive, W.h. Wilson Tang, Margaret M. Park, Nicholas S. Hill, Erika B. Rosenzweig
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is believed to involve both vascular obstruction and vasoconstriction; hence, pulmonary vasodilators such as riociguat may be beneficial. Acute vasoreactivity testing (AVT) is seldom perf
Externí odkaz:
https://doaj.org/article/1ad59bc7849242dca29b4335fa8f1ce5