Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nicholas S, Heaton"'
Autor:
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012345 (2024)
The CRISPR-Cas13 system has been proposed as an alternative treatment of viral infections. However, for this approach to be adopted as an antiviral, it must be optimized until levels of efficacy rival or exceed the performance of conventional approac
Externí odkaz:
https://doaj.org/article/ff2b71e5f2c14cc889ed30f7de84cd2e
Autor:
Samantha Skavicus, Nicholas S. Heaton
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Externí odkaz:
https://doaj.org/article/7493513197e842a48f69114077d077e7
Autor:
David J Bacsik, Bernadeta Dadonaite, Andrew Butler, Allison J Greaney, Nicholas S Heaton, Jesse D Bloom
Publikováno v:
eLife, Vol 12 (2023)
The ultimate success of a viral infection at the cellular level is determined by the number of progeny virions produced. However, most single-cell studies of infection quantify the expression of viral transcripts and proteins, rather than the amount
Externí odkaz:
https://doaj.org/article/9127c1486737475b8b8868e7d39955cd
Autor:
Joseph D. Trimarco, Sarah L. Nelson, Ryan R. Chaparian, Alexandra I. Wells, Nathan B. Murray, Parastoo Azadi, Carolyn B. Coyne, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of host antiviral restriction factors could provide targets for antiviral therapy. Here, using a genome-wide CRISPR screen, the authors identify the glycosyltransferase B3GAT1 as a host protein which, when ectopically overexpressed, re
Externí odkaz:
https://doaj.org/article/421acf3c2de24f58bda9a6d24454f5bd
Autor:
Heather M Froggatt, Kaitlyn N Burke, Ryan R Chaparian, Hector A Miranda, Xinyu Zhu, Benjamin S Chambers, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009951 (2021)
Influenza A viruses encode their genomes across eight, negative sense RNA segments. The six largest segments produce mRNA transcripts that do not generally splice; however, the two smallest segments are actively spliced to produce the essential viral
Externí odkaz:
https://doaj.org/article/5f9db5129dae43e99d5e7c7d6e8b2e01
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.
Autor:
Joseph D Trimarco, Brook E Heaton, Ryan R Chaparian, Kaitlyn N Burke, Raquel A Binder, Gregory C Gray, Clare M Smith, Vineet D Menachery, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009599 (2021)
Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt to complete
Externí odkaz:
https://doaj.org/article/485cd3cfaf524a5b9fa4517614d1a44a
Autor:
Rebekah E. Dumm, Jessica K. Fiege, Barbara M. Waring, Chay T. Kuo, Ryan A. Langlois, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Infection of a cell with influenza B virus (IBV) often results in cell death and the role of surviving cells in pathogenesis is unclear. Here, Dumm et al. generate a recombinant IBV that activates a host-cell reporter to permanently label infected ce
Externí odkaz:
https://doaj.org/article/9031272241854e39a95eb61c490bdf38
Autor:
Alfred T. Harding, Nicholas S. Heaton
Publikováno v:
Cancers, Vol 14, Iss 4, p 909 (2022)
Sex hormones, such as estrogen and testosterone, are steroid compounds with well-characterized effects on the coordination and development of vertebrate reproductive systems. Since their discovery, however, it has become clear that these “sex hormo
Externí odkaz:
https://doaj.org/article/1e328cb3883a4159a6f7cddbdbde6004
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008098 (2019)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting virion incompletely infectious. It is kn
Externí odkaz:
https://doaj.org/article/e46eed4b7dda409aba017274b569886d
Autor:
Brook E. Heaton, Edward M. Kennedy, Rebekah E. Dumm, Alfred T. Harding, Matthew T. Sacco, David Sachs, Nicholas S. Heaton
Publikováno v:
Cell Reports, Vol 20, Iss 7, Pp 1503-1512 (2017)
Influenza A virus (IAV) is a pathogen that poses significant risks to human health. It is therefore critical to develop strategies to prevent influenza disease. Many loss-of-function screens have been performed to identify the host proteins required
Externí odkaz:
https://doaj.org/article/e716c767ea214b789a87a430cce058b3