Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nicholas R. Wurtz"'
Autor:
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Externí odkaz:
https://doaj.org/article/87187fce26ae464386af76218484bf38
Autor:
Nicholas R. Wurtz, James A. Johnson, Andrew Viet, Pravin S. Shirude, Vishweshwaraiah Baligar, Sudhakara Madduri, Daniel L. Cheney, Hyunsoo Park, John A. Lupisella, Mei-Yin Hsu, Mojgan Abousleiman, Michael A. Galella, Darpandeep Aulakh, Elizabeth A. Dierks, Ricardo A. Garcia, Jacek Ostrowski, Ellen K. Kick, Ruth R. Wexler
Publikováno v:
ACS Med Chem Lett
[Image: see text] Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases. Many reported synthetic agonists contain a phenylurea, which appears to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a365e85b2833ea7dfaf2477aac5a41a
https://doi.org/10.1021/acsmedchemlett.2c00079
https://doi.org/10.1021/acsmedchemlett.2c00079
Autor:
John Lupisella, Stéphane St-Onge, Marilyn Carrier, Erica M. Cook, Tao Wang, Chi Sum, Gayani Fernando, Kendra Apgar, Rongan Zhang, Nancy Carson, Bradley J. Snyder, Carol S. Ryan, Xiuying Ma, Elizabeth A. Dierks, Sean Little, Ellen K. Kick, Nicholas R. Wurtz, Michel Bouvier, Madeleine Héroux, Ricardo A. Garcia
Publikováno v:
ACS pharmacologytranslational science. 5(10)
Formyl peptide receptor 2 (FPR2) plays an integral role in the transition of macrophages from a pro-inflammatory program to one that is pro-resolving. FPR2-mediated stimulation of resolution post myocardial infarction has demonstrated efficacy in rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b88f9437b178647894ccc435a7eb5d
https://pubmed.ncbi.nlm.nih.gov/36268126
https://pubmed.ncbi.nlm.nih.gov/36268126
Autor:
Stéphane St-Onge, Bruce R. Ito, John A. Lupisella, Madeleine Héroux, Ricardo Garcia, Marilyn Carrier, Mei-Yin Hsu, Carol S. Ryan, Michel Bouvier, Elizabeth A. Dierks, Nicholas R. Wurtz, Ellen K. Kick, Jian Chen, Nancy A. Carson, Gayani Fernando, Jordan Kelly Towne, Jacek Ostrowski, Francisco Villarreal, Himanshu Shah, Xiuying Ma, Marcela Sotelo Bucardo, Gabe Mintier, David A. Gordon
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c03af88d759da1d54a687d698b9a270
http://www.sciencedirect.com/science/article/pii/S2452302X19301962
http://www.sciencedirect.com/science/article/pii/S2452302X19301962
Autor:
Moises Muratt Bustamante-Pozo, Rongan Zhang, Nancy L. Carson, Madeleine Héroux, Michel Bouvier, Jian Chen, David A. Gordon, Bruce R. Ito, Stéphane St.-Onge, Gayani Fernando, Marilyn Carrier, Francisco Villarreal, Zhaoqing Wang, Alejandra Garate-Carrillo, Carol S. Ryan, Jignesh Nagar, Jacek Ostrowski, John A. Lupisella, Ricardo Garcia, Shailesh Dudhgaonkar, Debra Search, Ellen K. Kick, Xiuying Ma, Ruth R. Wexler, Mei-Yin Hsu, Elizabeth A. Dierks, Nicholas R. Wurtz, John Allocco
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response. • Selective activation of FPR2 on macrophages potentiates key cellular activities that enab
Highlights • MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response. • Selective activation of FPR2 on macrophages potentiates key cellular activities that enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e8893e04bab7931d672cda68a46242
https://pubmed.ncbi.nlm.nih.gov/34466754
https://pubmed.ncbi.nlm.nih.gov/34466754
Autor:
John A. Lupisella, Kiyoshi Fujii, David A. Gordon, Mei-Yin Hsu, Toshikazu Yamaoka, Yasuchi Kohno, Kohei Ohata, Kosuke Tsuda, Kazuto Arakawa, Nancy L. Carson, Kazunori Fukuchi, Ruth R. Wexler, Francisco Villarreal, Ellen K. Kick, Junichi Ishiyama, Jacek Ostrowski, Shingo Matsushima, Hitomi Yamada, Yoshifumi Saito, Bruce R. Ito, Yoshikazu Asahina, Ricardo Garcia, Nicholas R. Wurtz
Publikováno v:
Journal of medicinal chemistry. 63(17)
Formyl peptide receptor 2 (FPR2) agonists can stimulate resolution of inflammation and may have utility for treatment of diseases caused by chronic inflammation, including heart failure. We report the discovery of a potent and selective FPR2 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae320f52a2002341eb02a49f914b8d9d
https://pubmed.ncbi.nlm.nih.gov/32407089
https://pubmed.ncbi.nlm.nih.gov/32407089
Publikováno v:
Seminars in Immunology. 59:101602
Formyl peptide receptor type 2 (FPR2) regulates the initiation and resolution phases of the inflammatory response. In the setting of heart injury and disease, dysregulated inflammation can potentiate maladaptive healing and pathological remodeling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90651317e8ca052f0e6ade9b9129a0af
https://doi.org/10.1016/j.smim.2022.101602
https://doi.org/10.1016/j.smim.2022.101602
Autor:
Rongan Zhang, Gayani Fernando, Francisco Villarreal, Bruce R. Ito, Elizabeth A. Dierks, Nicholas R. Wurtz, Mei-Yin Hsu, Ricardo Garcia, John A. Lupisella, Y Kohno, Jacek Ostrowski, Carol S. Ryan, Nancy L. Carson, Zhaoqing Wang, Y Asahina
Publikováno v:
European Heart Journal. 40
Background/Introduction Dysregulated inflammation following myocardial infarction (MI) can lead to maladaptive infarct healing, myocardial damage and heart failure. Formyl peptide receptor 2 (FPR2) plays an important role in the ligand-dependent regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b688371cb14bd43dc42231a3265732e
https://doi.org/10.1093/eurheartj/ehz748.0168
https://doi.org/10.1093/eurheartj/ehz748.0168
Autor:
Monique Phillips, Brandon Parkhurst, E. Scott Priestley, Pancras C. Wong, Ruth R. Wexler, Xiaojun Zhang, Peter W. Glunz, Nicholas R. Wurtz, Daniel L. Cheney, Yan Zou, Ladziata Vladimir, Swanee Jacutin-Porte, Jiang Wen, Joseph M. Luettgen, James A. Johnson, Dietmar A. Seiffert, Alan R. Rendina, Timothy M. Harper
Publikováno v:
Journal of Medicinal Chemistry. 59:7125-7137
Inhibitors of the tissue factor (TF)/factor VIIa complex (TF-FVIIa) are promising novel anticoagulants which show excellent efficacy and minimal bleeding in preclinical models. Starting with an aminoisoquinoline P1-based macrocyclic inhibitor, optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b34dc28b27bae5c40db47c08ef65d
https://doi.org/10.1021/acs.jmedchem.6b00469
https://doi.org/10.1021/acs.jmedchem.6b00469
Autor:
Pancras C. Wong, Ruth R. Wexler, E. Scott Priestley, Daniel L. Cheney, Ladziata Vladimir, Yan Zou, Luciano Mueller, Nicholas R. Wurtz, Anzhi Wei, Peter W. Glunz
Publikováno v:
Journal of Medicinal Chemistry. 59:4007-4018
Incorporation of a methyl group onto a macrocyclic FVIIa inhibitor improves potency 10-fold but is accompanied by atropisomerism due to restricted bond rotation in the macrocyclic structure, as demonstrated by NMR studies. We designed a conformationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3c259a51a8e23fc52b982f3e27a60f
https://doi.org/10.1021/acs.jmedchem.6b00244
https://doi.org/10.1021/acs.jmedchem.6b00244