Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas R. Lees"'
Autor:
Andrew J. Devine, Alice E. Parnell, Catherine R. Back, Nicholas R. Lees, Samuel T. Johns, Ainul Z. Zulkepli, Rob Barringer, Katja Zorn, James E. M. Stach, Matthew P. Crump, Martin A. Hayes, Marc W. van der Kamp, Paul R. Race, Christine L. Willis
Publikováno v:
Angewandte Chemie. 135
Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using a combination of syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192ed9536efc507314b7a184d358c2a3
https://doi.org/10.1002/ange.202213053
https://doi.org/10.1002/ange.202213053
Autor:
Alexander J. A. Cobb, Kenneth Shankland, Callum D Johnston, Nicholas R. Lees, Laura A Bryant, Hannah Straker
Publikováno v:
Advanced Synthesis & Catalysis. 363:4067-4074
The organocatalytic transformation of resorcinols is extremely rare. In this article, we report a highly enantioselective, organocatalytic intramolecular cyclization of these systems by a Friedel-Crafts-type 1,4-addition using a Jorgensen-Hayashi-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::010f177fe705e7c4f543c910da66f997
https://doi.org/10.1002/adsc.202100647
https://doi.org/10.1002/adsc.202100647
Publikováno v:
J Am Chem Soc
The introduction of glycosides bearing basic nitrogen is challenging using conventional Lewis acid-promoted pathways owing to competitive coordination of the amine to the Lewis acid promoter. Additionally, because many aminoglycosides lack a C2 subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0c54cf0fb84238ff0c3d65367d394c
https://doi.org/10.1021/jacs.0c11262
https://doi.org/10.1021/jacs.0c11262
Autor:
Li-Chen Han, Matthew J. Byrne, James E. M. Stach, Carl O. Marsh, Nicholas R. Lees, Phillip W. Duke, Laurence Maschio, Sebastian Pagden‐Ratcliffe, Paul R. Race, Paul Curnow, Christine L. Willis, Sbusisiwe Z. Mbatha
Publikováno v:
Marsh, C O, Lees, N R, Han, L-C, Byrne, M J, Mbatha, S Z, Maschio, L, Pagden-Ratcliffe, S, Duke, P, Stach, J E M, Curnow, P, Willis, C L & Race, P R 2019, ' A Natural Diels-Alder Biocatalyst Enables Efficient [4 + 2] Cycloaddition Under Harsh Reaction Conditions ', ChemCatChem . https://doi.org/10.1002/cctc.201901285
Carbon‐carbon bond formation is a fundamental transformation in both synthetic chemistry and biosynthesis. Enzymes catalyze such reactions with exquisite selectivity which often cannot be achieved using non‐biological methods but may suffer from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1e17b701ba47a898ae6252727f14f4
https://doi.org/10.1002/cctc.201901285
https://doi.org/10.1002/cctc.201901285
Autor:
Jason M. Crawford, Nicholas R. Lees, Kevin M. Wernke, Seth B. Herzon, Chung Sub Kim, Alan R. Healy
Publikováno v:
Nature Chemistry. 11:890-898
The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. The clb pathway is found in gut commensal Escherichia coli, and clb metabolites are thought to initiate colorectal cancer via DNA crosslinking. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3112fd4ebe804a14721520652757d5d7
https://doi.org/10.1038/s41557-019-0338-2
https://doi.org/10.1038/s41557-019-0338-2
Autor:
Nicholas R. Lees, Li-Chen Han, Matthew J. Byrne, Jonathan A. Davies, Alice E. Parnell, Pollyanna E. J. Moreland, James E. M. Stach, Marc W. van der Kamp, Christine L. Willis, Paul R. Race
Publikováno v:
Angewandte Chemie. 131:2327-2331
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd6fa58d597a950176cbc7fbb72ea612
https://doi.org/10.1002/ange.201812105
https://doi.org/10.1002/ange.201812105
Publikováno v:
Journal of the American Chemical Society. 141(20)
Control of glycoside bond stereochemistry is the central challenge in the synthesis of oligosaccharides. 2-Deoxyglycosides, which lack a C2 substituent to guide stereoselectivity, are among the most difficult classes of glycoside bond constructions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1b438e5129d7fbecb058712a50dcc5
https://pubmed.ncbi.nlm.nih.gov/31059254
https://pubmed.ncbi.nlm.nih.gov/31059254
Autor:
Laurence, Maschio, Alice E, Parnell, Nicholas R, Lees, Christine L, Willis, Christiane, Schaffitzel, James E M, Stach, Paul R, Race
Publikováno v:
Methods in enzymology. 617
Polyketides are a structurally and functionally diverse family of bioactive natural products that have proven to be a rich source of pharmaceutical and agrochemical lead compounds. Many polyketides are biosynthesized by large multifunctional megaenzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f10192a59c9afc36ca0a791f65fd6f1
https://pubmed.ncbi.nlm.nih.gov/30784415
https://pubmed.ncbi.nlm.nih.gov/30784415
Autor:
Nicholas R. Lees, Christine L. Willis, Paul R. Race, James E. M. Stach, Christiane Schaffitzel, Alice E. Parnell, Laurence Maschio
Polyketides are a structurally and functionally diverse family of bioactive natural products that have proven to be a rich source of pharmaceutical and agrochemical lead compounds. Many polyketides are biosynthesized by large multifunctional megaenzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aca2aeb8c8f606e4e3d66f65c44efdd
https://doi.org/10.1016/bs.mie.2018.12.018
https://doi.org/10.1016/bs.mie.2018.12.018
Autor:
James E. M. Stach, Nicholas R. Lees, Jonathan A. Davies, Matthew J. Byrne, Marc W. van der Kamp, Alice E. Parnell, Christine L. Willis, Paul R. Race, Pollyanna E. J. Moreland, Li-Chen Han
Publikováno v:
Lees, N R, Han, L-C, Byrne, M, Davies, J, Parnell, A, Moreland, P, Stach, J E M, Van der Kamp, M, Willis, C & Race, P 2019, ' An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis ', Angewandte Chemie-International Edition, vol. 58, no. 8, pp. 2305-2309 . https://doi.org/10.1002/anie.201812105
Spirotetronate and spirotetramate natural products include a multitude of compounds with potent antimicrobial and antitumor activities. Their biosynthesis incorporates many unusual biocatalytic steps, including regio- and stereo-specific modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83468de882a82f0f473db0ae25fc9e02
https://pubmed.ncbi.nlm.nih.gov/30664319
https://pubmed.ncbi.nlm.nih.gov/30664319