Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Nicholas R Silvaggi"'
Autor:
Xuechen Zhu, Rongbin Wang, Vilja Siitonen, Nemanja Vuksanovic, Nicholas R Silvaggi, Charles E Melançon Iii, Mikko Metsä-Ketelä
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308684 (2024)
The biosynthetic pathway of actinorhodin in Streptomyces coelicolor A3(2) has been studied for decades as a model system of type II polyketide biosynthesis. The actinorhodin biosynthetic gene cluster includes a gene, actVI-orfA, that encodes a protei
Externí odkaz:
https://doaj.org/article/18d3d410d6f4415d808198f9e8cc3dfd
Autor:
David G Glanville, Lanlan Han, Andrew F Maule, Alexandra Woodacre, Devsaagar Thanki, Iman Tajer Abdullah, Julie A Morrissey, Thomas B Clarke, Hasan Yesilkaya, Nicholas R Silvaggi, Andrew T Ulijasz
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007052 (2018)
To survive diverse host environments, the human pathogen Streptococcus pneumoniae must prevent its self-produced, extremely high levels of peroxide from reacting with intracellular iron. However, the regulatory mechanism(s) by which the pneumococcus
Externí odkaz:
https://doaj.org/article/6e71c3ba02764d75bcc64dfb36ff03c7
Autor:
Andrew F Maule, David P Wright, Joshua J Weiner, Lanlan Han, Francis C Peterson, Brian F Volkman, Nicholas R Silvaggi, Andrew T Ulijasz
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004795 (2015)
Two-component signaling systems are ubiquitous in bacteria, Archaea and plants and play important roles in sensing and responding to environmental stimuli. To propagate a signaling response the typical system employs a sensory histidine kinase that p
Externí odkaz:
https://doaj.org/article/76130a7903044f98ac2797606428d74b
Publikováno v:
Methods in Enzymology ISBN: 9780443152764
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6be59ee2b2b2db82fec64282c49332f8
https://doi.org/10.1016/bs.mie.2023.03.010
https://doi.org/10.1016/bs.mie.2023.03.010
Autor:
Nikki Johnston, Tina L. Samuels, Christopher J. Goetz, Leggy A. Arnold, Brian C. Smith, Donna Seabloom, Beverly Wuertz, Frank Ondrey, Timothy S. Wiedmann, Nemanja Vuksanovic, Nicholas R. Silvaggi, Alexander C. MacKinnon, James Miller, Jonathan Bock, Joel H. Blumin
Publikováno v:
The Laryngoscope. 133
More than 20% of the US population suffers from laryngopharyngeal reflux. Although dietary/lifestyle modifications and alginates provide benefit to some, there is no gold standard medical therapy. Increasing evidence suggests that pepsin is partly, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34d823dbe07f5af7d386ca7ab71176c
https://doi.org/10.1002/lary.30242
https://doi.org/10.1002/lary.30242
MppQ is an enzyme of unknown function from Streptomyces hygroscopicus that is involved in the biosynthesis of the nonproteinogenic amino acid L-enduracididine (L-End). Since L-End is a component of several peptides showing high activity against methi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0f1370d00fc4025512d72316444a67
https://doi.org/10.1101/2022.04.03.486910
https://doi.org/10.1101/2022.04.03.486910
The E. coli glyoxylate reductase/hydroxypyruvate reductase A (EcGhrA) was investigated as a coupling enzyme to monitor the transamination of 2-ketoarginine and glycine by the L-enduracididine biosynthetic enzyme MppQ. Surprisingly, 2-ketoarginine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4c4281e4b0c01415fe5d5741ca52c0e
https://doi.org/10.1101/2022.04.02.486822
https://doi.org/10.1101/2022.04.02.486822
Autor:
Nemanja Vuksanovic, Rajdeep S Virdi, Trevor R Melkonian, Robert Bavisotto, Nicholas Hopper, Nicholas R. Silvaggi, David N. Frick
Publikováno v:
Slas Discovery
bioRxiv
bioRxiv
The Mac1 domain of the multifunctional SARS-CoV-2 non-structural protein 3 (nsp3) is a potential COVID-19 drug target because it is suspected to enhance the ability of the virus to evade the human immune system. The SARS-CoV-2 Mac1 domain binds ADP-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79149885fd5d4a061115aef8bb6f5866
http://europepmc.org/articles/PMC7684785
http://europepmc.org/articles/PMC7684785
Publikováno v:
Biochemistry. 58:4136-4147
The acetoacetate decarboxylase-like superfamily (ADCSF) is a little-explored group of enzymes that may contain new biocatalysts. The low level of sequence identity (∼20%) between many ADCSF enzymes and the confirmed acetoacetate decarboxylases led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1efa9a7a9a2d73c128463ef79d58f4b0
https://doi.org/10.1021/acs.biochem.9b00652
https://doi.org/10.1021/acs.biochem.9b00652
Autor:
Antonio J Campedelli, Kim D. Janda, Karen N. Allen, Nicholas R. Silvaggi, Amanda E Wakefield, Jason S. Chen, Alexander L. Nielsen, Lucy Lin, Lewis D. Turner
Publikováno v:
ACS Med Chem Lett
[Image: see text] Botulinum neurotoxins (BoNTs) are extremely toxic and have been deemed a Tier 1 potential bioterrorism agent. The most potent and persistent of the BoNTs is the “A” serotype, with strategies to counter its etiology focused on de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6468dc8ab60309aa56a634946c5a3f0e
https://pubmed.ncbi.nlm.nih.gov/34413962
https://pubmed.ncbi.nlm.nih.gov/34413962