Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Nicholas R J Gascoigne"'
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009253 (2021)
The human gut microbiota is a diverse and complex ecosystem that is involved in beneficial physiological functions as well as disease pathogenesis. Blastocystis is a common protistan parasite and is increasingly recognized as an important component o
Externí odkaz:
https://doaj.org/article/e147baafc30f4bc49944efdd17b2bfc8
Autor:
Vasily Rybakin, Luise Westernberg, Guo Fu, Hee-Ok Kim, Jeanette Ampudia, Karsten Sauer, Nicholas R J Gascoigne
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114320 (2014)
Development of thymocytes through the positive selection checkpoint requires the rearrangement and expression of a suitable T cell receptor (TCR) α-chain that can pair with the already-expressed β-chain to make a TCR that is selectable. That is, it
Externí odkaz:
https://doaj.org/article/ab3454fa25b1406396375172af2a3f92
Autor:
Sayak Mukherjee, Stephanie Rigaud, Sang-Cheol Seok, Guo Fu, Agnieszka Prochenka, Michael Dworkin, Nicholas R J Gascoigne, Veronica J Vieland, Karsten Sauer, Jayajit Das
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73937 (2013)
The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP4) is essential for thymocyte positive selection by regulating plasma-membrane association of the protein tyrosine kinase Itk downstream of the T cell receptor (TCR). IP4 can act
Externí odkaz:
https://doaj.org/article/6d4f84af532a4166a083be6fd3b99e30
Autor:
Vasily Rybakin, Nicholas R J Gascoigne
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43191 (2012)
Thymocyte negative selection is a requirement for the development of self tolerance. Although it is possible to assay the induction of cell death in thymocytes in vitro using antibody cross-linking, this stimulus is much stronger than the normal rang
Externí odkaz:
https://doaj.org/article/a989ff7b21ca4dcdbe56a0591c5c1932
Autor:
Jian Tang, Xian Jia, Jian Li, Junchen Dong, Jiayu Wang, Wanyun Li, Yuzhen Zhu, Yanyan Hu, Bowen Hou, Chunjie Lin, Yu Cong, Tong Ren, Changsheng Yan, Hongying Yang, Qian Lai, Haiping Zheng, Yuzhou Bao, Namrata Gautam, Hong-Rui Wang, Bing Xu, Xiao Lei Chen, Qing Li, Nicholas R. J. Gascoigne, Guo Fu
Publikováno v:
Cellular & Molecular Immunology. 20:512-524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1252d8cd469ac25889e8f4c78af6e787
https://doi.org/10.1038/s41423-023-00997-z
https://doi.org/10.1038/s41423-023-00997-z
Autor:
Lei Deng, Lukasz Wojciech, Chin Wen Png, Yan Qin Dorinda Kioh, Geok Choo Ng, Eric Chun Yong Chan, Yongliang Zhang, Nicholas R. J. Gascoigne, Kevin Shyong Wei Tan
Publikováno v:
npj Biofilms and Microbiomes. 9
Blastocystis is a species complex that exhibits extensive genetic diversity, evidenced by its classification into several genetically distinct subtypes (ST). Although several studies have shown the relationships between a specific subtype and gut mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325257f3c7ad3e4ec750c5070a485d6e
https://doi.org/10.1038/s41522-023-00389-1
https://doi.org/10.1038/s41522-023-00389-1
Publikováno v:
EMBO reports. 24
T cell activation and effector functions are determined by the affinity of the interaction between T cell receptor (TCR) and its antigenic peptide MHC (pMHC) ligand. A better understanding of the quantitative aspects of TCR-pMHC affinity-dependent T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af0c1ef7617a07e48bef4a85239752a
https://doi.org/10.15252/embr.202254969
https://doi.org/10.15252/embr.202254969
Autor:
Neil Q. Tay, Debbie C. P. Lee, Yen Leong Chua, Nayana Prabhu, Nicholas R. J. Gascoigne, David M. Kemeny
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
CD8+ T cells play an important role in providing protective immunity against a wide range of pathogens, and a number of different factors control their activation. Although CD40L-mediated CD40 licensing of dendritic cells (DCs) by CD4+ T cells is kno
Externí odkaz:
https://doaj.org/article/1e4221065f454e70988556de08ce40c0
Autor:
Huey Yee Teo, Yuan Song, Kylie Su Mei Yong, Yonghao Liu, Yu Mei, Zuhairah Binte Hanafi, Ying Zhu, Nicholas R. J. Gascoigne, Qingfeng Chen, Haiyan Liu
γδT cells are promising candidates for cellular immunotherapy due to their immune regulation through cytokine production and MHC-independent direct cytotoxicity against a broad spectrum of tumors. However, current γδT cell-based cancer immunother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22ec80a5de428df0a4d54e3ca731d95c
https://doi.org/10.1101/2022.08.11.503563
https://doi.org/10.1101/2022.08.11.503563
Autor:
Yongliang Zhang, Heng Boon Low, Yik-Lam Cho, Herbert Schwarz, Nicholas R. J. Gascoigne, Fengchun Xiao, Chin Wen Png, Fiona Yi Xin Lee, Xiaohong Xu, Bangyuan Wu, Jia Min Loo, Han-Ming Shen, Li Ren Kong, Henry Yang, Ramanuj DasGupta, Zhen Lim Wong, Xuan Xin, Chun-Wei Li, Boon Cher Goh, Iain Beehuat Tan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc584b47087c28dbb44baabfd0779768
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d