Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicholas R F, Hannan"'
Autor:
Lara C. Lewis, Peggy Cho Kiu Lo, Jeremy M. Foster, Nan Dai, Ivan R. Corrêa, Paulina M. Durczak, Gary Duncan, Ashley Ramsawhook, Guruprasad Padur Aithal, Chris Denning, Nicholas R. F. Hannan, Alexey Ruzov
Publikováno v:
Epigenetics, Vol 12, Iss 4, Pp 277-286 (2017)
Patterns of DNA methylation (5-methylcytosine, 5mC) are rearranged during differentiation contributing to the regulation of cell type-specific gene expression. TET proteins oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-
Externí odkaz:
https://doaj.org/article/20cafdd844e340c596c7cad776addb54
A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells
Autor:
Gray, Sara Cuevas-Ocaña, Jin Ye Yang, Magomet Aushev, George Schlossmacher, Christine E. Bear, Nicholas R. F. Hannan, Neil D. Perkins, Janet Rossant, Amy P. Wong, Michael A.
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10266
Introducing or correcting disease-causing mutations through genome editing in human pluripotent stem cells (hPSCs) followed by tissue-specific differentiation provide sustainable models of multiorgan diseases, such as cystic fibrosis (CF). However, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::2aca7e9c88cb999b574f1b838570cbcb
Autor:
Richard L Gieseck, Nicholas R F Hannan, Roque Bort, Neil A Hanley, Rosemary A L Drake, Grant W W Cameron, Thomas A Wynn, Ludovic Vallier
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86372 (2014)
Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in applications ranging from therapeutic cell infusions to in vitro toxicology studies. However, curren
Externí odkaz:
https://doaj.org/article/9f6b9f4dd535417faa7c438470c69ea3
Autor:
Alessandro, Bertero, Matthias, Pawlowski, Daniel, Ortmann, Kirsten, Snijders, Loukia, Yiangou, Miguel, Cardoso de Brito, Stephanie, Brown, William G, Bernard, James D, Cooper, Elisa, Giacomelli, Laure, Gambardella, Nicholas R F, Hannan, Dharini, Iyer, Fotios, Sampaziotis, Felipe, Serrano, Mariëlle C F, Zonneveld, Sanjay, Sinha, Mark, Kotter, Ludovic, Vallier
Publikováno v:
Development (Cambridge, England)
Inducible loss of gene function experiments are necessary to uncover mechanisms underlying development, physiology and disease. However, current methods are complex, lack robustness and do not work in multiple cell types. Here we address these limita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffd603f7794af59054077f59f671b941
https://pubmed.ncbi.nlm.nih.gov/27899508
https://pubmed.ncbi.nlm.nih.gov/27899508
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1250
Hepatocytes produced from the differentiation of human pluripotent stem cells can be used to study human development and liver disease, to investigate the toxicological response of novel drug candidates, and as an alternative source of primary cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99a61d7608f828fe0a0fb7de3784aa91
https://pubmed.ncbi.nlm.nih.gov/26272139
https://pubmed.ncbi.nlm.nih.gov/26272139
Autor:
Thomas Touboul, Nicholas R. F. Hannan, Sébastien Corbineau, Amélie Martinez, Clémence Martinet, Sophie Branchereau, Sylvie Mainot, Hélène Strick-Marchand, Roger Pedersen, James Di Santo, Anne Weber, Ludovic Vallier
Publikováno v:
Hepatology. 52:402-402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bff595c69f84c9e35201bddb5ab48c0
https://doi.org/10.1002/hep.23752
https://doi.org/10.1002/hep.23752