Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Nicholas R, Natale"'
Autor:
Brent R. Lyda, Gregory P. Leary, Jill Farnsworth, Benjamin Seaver, Derek Silvius, Michael P. Kavanaugh, C. Sean Esslinger, Nicholas R. Natale
Publikováno v:
Molecules, Vol 29, Iss 10, p 2330 (2024)
As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors
Externí odkaz:
https://doaj.org/article/09739a5a115743fe8c51173f32001947
Publikováno v:
Crystals, Vol 14, Iss 3, p 256 (2024)
In pursuit of unsymmetrical precursors for the novel series of anthracenyl-isoxazole amide (AIM) antitumor agents, a series of substituted anthracenes were subjected to bromination and re-aromatization in our study, during which we solved four single
Externí odkaz:
https://doaj.org/article/37917addf0fb4761a08ea47b67e1735b
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 11, Pp 1089-1096 (2022)
Three hexahydroquinoline derivatives were synthesized and crystallized in an effort to study the structure–activity relationships of these calcium-channel antagonists. The derivatives are ethyl 4-(2-methoxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-
Externí odkaz:
https://doaj.org/article/c2f30f84d4734cc3af47dd0758e457a0
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 7, Pp 703-708 (2022)
The syntheses and structures of an unexpected by-product from an iodination reaction, namely, ethyl 5-methyl-3-(10-nitroanthracen-9-yl)isoxazole-4-carboxylate, C21H16N2O5, (I), and its oxidation product, ethyl 3-(9-hydroxy-10-oxo-9,10-dihydroanthrace
Externí odkaz:
https://doaj.org/article/7bca91f4469d48b5bedf400ad5ac99c9
Publikováno v:
Molecules, Vol 28, Iss 19, p 6800 (2023)
Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR1a, mGluR5, or mGluR8. Additional analo
Externí odkaz:
https://doaj.org/article/8c074562c3ad478d806719d1f0a7c36d
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 2, Pp 125-131 (2020)
The title compound I, 2,2′-[(2-nitrophenyl)methylene]bis(3-hydroxy-5,5-dimethylcyclohex-2-enone), C23H27NO6, features a 1,3-ketone–enol conformation which is stabilized by two intramolecular hydrogen bonds. The most prominent intermolecular inter
Externí odkaz:
https://doaj.org/article/0863ded8dce445cfaabf62d1dd47c4e1
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 10, Pp 1417-1420 (2018)
In the title racemic compound, ethyl 4-(4-dimethylaminophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, the common structural features in this type of compound, such as the flat-boat conformation of the 1,4-dihydropyridine
Externí odkaz:
https://doaj.org/article/ee740c5bd8cb448aae29b4ee094904d1
Autor:
Lindsay M. Achzet, Fanny Astruc-Diaz, Phillip H. Beske, Nicholas R. Natale, Travis T. Denton, Darrell A. Jackson
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 636 (2021)
Strokes remain one of the leading causes of disability within the United States. Despite an enormous amount of research effort within the scientific community, very few therapeutics are available for stroke patients. Cytotoxic accumulation of intrace
Externí odkaz:
https://doaj.org/article/597c70f3004c4cb4957010e25f2efc02
Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205584 (2018)
The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III1 region of the c-MYC promoter forms a DNA quadruplex. Stabilization of this structure with small mole
Externí odkaz:
https://doaj.org/article/d4e11fbb95874064b04098d7986a2101
Publikováno v:
Acta Crystallographica Section E Crystallographic Communications. 76:1818-1822
The title compound, C26H20N2O5, is a rearrangement product of an o-pyridinyl anthracenyl isoxazole ester. It features a bicyclic acetal structure, which has two extended almost co-planar ring systems, which subtend a fold angle of 102.17 (5)°. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a412c94d11226271dd8a29bff0af6ff
https://doi.org/10.1107/s2056989020014358
https://doi.org/10.1107/s2056989020014358