Výsledky vyhledávání - "Nicholas R, Klug"

Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries

Autor: Osama F. Harraz, Nicholas R. Klug, Amanda J. Senatore, David C. Hill-Eubanks, Mark T. Nelson

Publikováno v: Circ Res

Capillaries are equipped to sense neurovascular coupling agents released onto the outer wall of a capillary, translating these external signals into electrical/Ca 2+ changes that play a crucial role in blood flow regulation and ensuring that neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574af6ef914c3f19f064e4bdbec09fe5
https://europepmc.org/articles/PMC9106929/

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Adenosine signaling activates ATP-sensitive K(+) channels in endothelial cells and pericytes in CNS capillaries

Autor: Maria Sancho, Nicholas R. Klug, Amreen Mughal, Masayo Koide, Saul Huerta de la Cruz, Thomas J. Heppner, Adrian D. Bonev, David Hill-Eubanks, Mark T. Nelson

Publikováno v: Sci Signal

The dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron- and glial-derived compounds that enhance regional and global cerebral perfus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3454ce1c75f0c8fb2383cf7f7d31555e
https://europepmc.org/articles/PMC9623876/

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Kv2.1 channels play opposing roles in regulating membrane potential, Ca 2+ channel function, and myogenic tone in arterial smooth muscle

Autor: Laura Guarina, Samantha O’Dwyer, L. Fernando Santana, James S. Trimmer, Collin Matsumoto, Barbara Rosati, Nicholas R. Klug, David McKinnon, Sendoa Tajada, Stephanie Palacio

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 7
Proceedings of the National Academy of Sciences of the United States of America

Significance Our data challenge the generally accepted view that Kv2.1 proteins regulate arterial smooth muscle function by regulating their membrane potential. Rather, we discovered that Kv2.1 plays both conductive and structural roles with opposing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d055ecc155ca71fbda75d38ea3d2ea
https://doi.org/10.1073/pnas.1917879117

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Piezo1 is a mechanosensor channel in CNS capillaries

Autor: Mark T. Nelson, Amanda Senatore, Nicholas R. Klug, Masayo Koide, Osama F. Harraz

Publikováno v: Journal of General Physiology. 154

Cerebral blood flow (CBF) is exquisitely controlled to meet the ever-changing demands of active neurons in the brain. Brain capillaries are equipped with sensors of neurovascular coupling agents released from neurons/astrocytes onto the outer wall of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::243d6241d8d9c69eff750607b33ff286
https://doi.org/10.1085/jgp.2021ecc12

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Enhanced Vascular Contractility Following Secondhand Smoke Exposure: A Pathological 'Double-hit' to Critical Smooth Muscle Ion Channels

Autor: Mark T. Nelson, Nicholas R. Klug

Publikováno v: Function. 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c39e2b779f87319a6873410fa4bce66
https://doi.org/10.1093/function/zqab061

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Electro-Metabolic Sensing Through Capillary ATP-Sensitive K+ Channels and Adenosine to Control Cerebral Blood Flow

Autor: Amreen Mughal, Thomas J. Heppner, Mark T. Nelson, Maria Sancho, David C. Hill-Eubanks, Nicholas R. Klug

SUMMARYThe dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuro/glial-derived compounds that regulate regional and global cerebral perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fce172501c7fdf5121f08212f17f3a4
https://doi.org/10.1101/2021.03.12.435152

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High glucose-induced effects on Na

Autor: Nicholas R, Klug, Olga V, Chechneva, Benjamin Y, Hung, Martha E, O'Donnell

Publikováno v: Am J Physiol Cell Physiol

Hyperglycemia exacerbates edema formation and worsens neurological outcome in ischemic stroke. Edema formation in the early hours of stroke involves transport of ions and water across an intact blood-brain barrier (BBB), and swelling of astrocytes. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9f5ad6e6d82df304fb0f3dca5211e2f
https://pubmed.ncbi.nlm.nih.gov/33406028

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Contractile pericytes determine the direction of blood flow at capillary junctions

Autor: Mark T. Nelson, Nikolaos M. Tsoukias, Michael I. Kotlikoff, Frank K. Lee, Bo Shui, Albert L. Gonzales, Jane C. Lee, Arash Moshkforoush, David C. Hill-Eubanks, Nicholas R. Klug

Publikováno v: PNAS
Proc Natl Acad Sci U S A

The essential function of the circulatory system is to continuously and efficiently supply the O(2) and nutrients necessary to meet the metabolic demands of every cell in the body, a function in which vast capillary networks play a key role. Capillar

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Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

Autor: Monara Kaelle Servulo Cruz Angelim, Nicholas R. Klug, Julien Ratelade, Mark T. Nelson, Valérie Domenga-Denier, Fabrice Dabertrand, Anne Joutel, Damiano Lombardi, Rustam Al-Shahi Salman, Colin Smith, Jean-Frédéric Gerbeau

Publikováno v: Circulation
Circulation, American Heart Association, 2020, 141 (25), pp.2078-2094. ⟨10.1161/CIRCULATIONAHA.119.040963⟩
Circulation, 2020, 141 (25), pp.2078-2094. ⟨10.1161/CIRCULATIONAHA.119.040963⟩
Ratelade, J, Klug, N, Lombardi, D, Cruz Angelim, MKS, Dabertrand, F, Domenga-Denier, V, Salam, RA & Nelson, M 2020, ' Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage. ', Circulation . https://doi.org/10.1161/circulationaha.119.040963
Circulation, American Heart Association, 2020, Epub ahead of print. ⟨10.1161/CIRCULATIONAHA.119.040963⟩
Ratelade, J, Klug, N R, Lombardi, D, Angelim, M K S C, Dabertrand, F, Domenga-denier, V, Al-shahi Salman, R, Smith, C, Gerbeau, J, Nelson, M T & Joutel, A 2020, ' Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.119.040963

Background: Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of stroke without specific treatments. It has been thought that smooth muscle cell (SMC) degeneration at the site of arteriolar wall rupture may be sufficient to cau

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