Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicholas R, Ader"'
Autor:
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski
Publikováno v:
eLife, Vol 8 (2019)
During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it. However, it remains unclear how outer membrane o
Externí odkaz:
https://doaj.org/article/03350d01eeaf4eab9e7aff73e995dd05
Autor:
Thomas J. Melia, C. Patrick Lusk, Megan C. King, Philip J. Mannino, Nicholas R. Ader, David J Thaller, Sunandini Chandra
Publikováno v:
The Journal of cell biology. 220(12)
Mechanisms that turnover components of the nucleus and inner nuclear membrane (INM) remain to be fully defined. We explore how components of the INM are selected by a cytosolic autophagy apparatus through a transmembrane nuclear envelope-localized ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c7feeb6859cf1c6d3ee68cb24f0b39
https://pubmed.ncbi.nlm.nih.gov/34714326
https://pubmed.ncbi.nlm.nih.gov/34714326
Autor:
Danqing Tong, David J Thaller, Nicholas R. Ader, Philip J. Mannino, Megan C. King, Sapan Borah, Barbara Ciani, C. Patrick Lusk, Christopher J. Marklew
Publikováno v:
The Journal of Cell Biology
Thaller et al. demonstrate that direct binding between phosphatidic acid (PA) and the ESCRT Chm7 is required for nuclear envelope surveillance; PA also accumulates at nuclear envelope herniations. Thus, tight control of PA metabolism is required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338c89afde91f8f4018847f226d4495d
http://europepmc.org/articles/PMC7816628
http://europepmc.org/articles/PMC7816628
Autor:
Nicholas R. Ader, C. Patrick Lusk
Publikováno v:
Curr Opin Cell Biol
Understanding how the integrity of the nuclear membranes is protected against internal and external stresses is an emergent challenge. Work reviewed here investigated the mechanisms by which losses of nuclear-cytoplasmic compartmentalization are sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a6c6a6dd81d4621af9fb63719a8abd
https://europepmc.org/articles/PMC7371540/
https://europepmc.org/articles/PMC7371540/
Autor:
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it. However, it remains unclear how outer membrane o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e309287bacbc030c9d26e3f08a6cfc7
https://pubmed.ncbi.nlm.nih.gov/30714902
https://pubmed.ncbi.nlm.nih.gov/30714902
Publikováno v:
Toxicology letters
The Nrf2 transcription factor is a master regulator of the cellular defense against oxidative and electrophilic stress. An increase in Nrf2 protein levels and an accumulation of Nrf2 in the nucleus are key parts of the Nrf2 activation mechanism. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04581deae2b0a4159a5e211c05c1f29
http://europepmc.org/articles/PMC4705856
http://europepmc.org/articles/PMC4705856
Autor:
Nicholas R. Ader
Publikováno v:
The Journal of Neuroscience. 36:11165-11167
Despite the passage of nearly two centuries since James Parkinson penned his seminal work, “An Essay on the Shaking Palsy,” the neurobiology of the disease that now shares his name remains unclear ([Parkinson, 2002][1]). Although the majority of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63f7dd27de14ff6fa49e5191377eb70f
https://doi.org/10.1523/jneurosci.2525-16.2016
https://doi.org/10.1523/jneurosci.2525-16.2016
Autor:
Nicholas R, Ader, Wanda, Kukulski
Publikováno v:
Methods in cell biology. 140
Fiducial-based correlation of fluorescence and electron microscopy data from high-pressure frozen and resin-embedded samples allows for high-precision localization of fluorescent signals to subcellular ultrastructure. Here we introduce the triCLEM pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdc0b4703c98b34be365c32f1c113a38
https://pubmed.ncbi.nlm.nih.gov/28528638
https://pubmed.ncbi.nlm.nih.gov/28528638
Autor:
Nicholas R. Ader, Wanda Kukulski
Fiducial-based correlation of fluorescence and electron microscopy data from high-pressure frozen and resin-embedded samples allows for high-precision localization of fluorescent signals to subcellular ultrastructure. Here we introduce the triCLEM pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbc5539f56466f0f4db39432fdbddecd
https://doi.org/10.1016/bs.mcb.2017.03.009
https://doi.org/10.1016/bs.mcb.2017.03.009