Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicholas Provine"'
Autor:
Anna Fowler, Michael FitzPatrick, Aberami Shanmugarasa, Amro Sayed Fadel Ibrahim, Hannah Kockelbergh, Han-Chieh Yang, Amelia Williams-Walker, Kim Ngan Luu Hoang, Shelley Evans, Nicholas Provine, Paul Klenerman, Elizabeth J. Soilleux
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1707 (2023)
Coeliac disease (CeD) is a T-cell mediated enteropathy triggered by dietary gluten which remains substantially under-diagnosed around the world. The diagnostic gold-standard requires histological assessment of intestinal biopsies taken at endoscopy w
Externí odkaz:
https://doaj.org/article/965f330abc59469c9e7f54cb7024adb4
Autor:
Adrienn Angyal, PhD, Stephanie Longet, PhD, Shona C Moore, PhD, Rebecca P Payne, DPhil, Adam Harding, MSc, Tom Tipton, PhD, Patpong Rongkard, MSc, Mohammad Ali, MD, Luisa M Hering, MSc, Naomi Meardon, MBChB, James Austin, PhD, Rebecca Brown, PhD, Donal Skelly, PhD, Natalie Gillson, BSc, Sue L Dobson, MSc, Andrew Cross, PhD, Gurjinder Sandhar, MSc, Jonathan A Kilby, MSc, Jessica K Tyerman, BSc, Alexander R Nicols, MSc, Jarmila S Spegarova, PhD, Hema Mehta, DPhil, Hailey Hornsby, MSc, Rachel Whitham, MSc, Christopher P Conlon, ProfPhD, Katie Jeffery, PhD, Philip Goulder, ProfDPhil, John Frater, ProfPhD, Christina Dold, PhD, Matthew Pace, PhD, Ane Ogbe, PhD, Helen Brown, BSc, M Azim Ansari, DPhil, Emily Adland, PhD, Anthony Brown, BSc, Meera Chand, FRCPath, Adrian Shields, PhD, Philippa C Matthews, PhD, Susan Hopkins, PhD, Victoria Hall, PhD, William James, ProfDPhil, Sarah L Rowland-Jones, ProfDM, Paul Klenerman, ProfPhD, Susanna Dunachie, ProfPhD, Alex Richter, ProfPhD, Christopher J A Duncan, DPhil, Eleanor Barnes, ProfPhD, Miles Carroll, ProfPhD, Lance Turtle, PhD, Thushan I de Silva, PhD, Adam Harding, Adam Watson, Adrian Shields, Adrienn Angyal, Ahmed Alhussni, Alex Richter, Alexander Nicols, Alexandra Deeks, Alice Webb-Bridges, Andrew Cross, Ane Ogbe, Anni Jämsén, Anthony Brown, Anu Chawla, Christina Dold, Christopher Duncan, Christopher Conlon, Donal Skelly, Denise O'Donnell, Eleanor Barnes, Emily Adland, Esme Weeks, Gurjinder Sandhar, Hailey Hornsby, Helen Brown, Hema Mehta, Hibatullah Abuelgasim, Huiyuan Xiao, James Austin, Jarmila Spegarova, Jennifer Holmes, Jenny Haworth, Jessica Tyerman, John Frater, Jonathan Kilby, Joseph Cutteridge, Katie Jeffery, Katy Lillie, Lance Turtle, Leigh Romaniuk, Lucy Denly, Luisa Hering, M. Azim Ansari, Matthew Pace, Meera Chand, Miles Carroll, Mohammad Ali, Mwila Kasanyinga, Naomi Meardon, Natalie Gillson, Patpong Rongkard, Paul Klenerman, Philip Goulder, Philippa Matthews, Rachel Whitham, Rebecca Brown, Rebecca Payne, Robert Wilson, Sarah Rowland-Jones, Sarah Thomas, Shona Moore, Siobhan Gardiner, Stephanie Longet, Stephanie Tucker, Sue Dobson, Susan Hopkins, Susanna Dunachie, Syed Adlou, Thushan de Silva, Tom Tipton, Victoria Hall, William James, Allan Lawrie, Nikki Smith, Helena Turton, Amira Zawia, Martin Bayley, Alex Fairman, Kate Harrington, Rosemary Kirk, Louise Marsh, Lisa Watson, Steven Wood, Benjamin Diffey, Chris Jones, Lauren Lett, Gareth Platt, Krishanthi Subramaniam, Daniel Wootton, Brendan Payne, Sophie Hambleton, Sinead Kelly, Judith Marston, Sonia Poolan, Dianne Turner, Muzlifah Haniffa, Emily Stephenson, Sandra Adele, Hossain Delowar Akhter, Senthil Chinnakannan, Catherine de Lara, Timothy Donnison, Carl-Philipp Hackstein, Lian Lee, Nicholas Lim, Tom Malone, Eloise Phillips, Narayan Ramamurthy, Nichola Robinson, Oliver Sampson, David Eyre, Beatrice Simmons, Lizzie Stafford, Alexander Mentzer, Ali Amini, Carolina Arancibia-Cárcamo, Nicholas Provine, Simon Travis, Stavros Dimitriadis, Sile Johnson, Sarah Foulkes, Jameel Khawam, Edgar Wellington, Javier Gilbert-Jaramillo, Michael Knight, Maeva Dupont, Emily Horner, James Thaventhiran, Jeremy Chalk
Publikováno v:
The Lancet Microbe, Vol 3, Iss 1, Pp e21-e31 (2022)
Summary: Background: Previous infection with SARS-CoV-2 affects the immune response to the first dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and antibody responses in health-care workers with and without previous SA
Externí odkaz:
https://doaj.org/article/d48a073da959456b9ed11417935ce5d7
Autor:
Rebecca P. Payne, Stephanie Longet, James A. Austin, Donal T. Skelly, Wanwisa Dejnirattisai, Sandra Adele, Naomi Meardon, Sian Faustini, Saly Al-Taei, Shona C. Moore, Tom Tipton, Luisa M. Hering, Adrienn Angyal, Rebecca Brown, Alexander R. Nicols, Natalie Gillson, Susan L. Dobson, Ali Amini, Piyada Supasa, Andrew Cross, Alice Bridges-Webb, Laura Silva Reyes, Aline Linder, Gurjinder Sandhar, Jonathan A. Kilby, Jessica K. Tyerman, Thomas Altmann, Hailey Hornsby, Rachel Whitham, Eloise Phillips, Tom Malone, Alexander Hargreaves, Adrian Shields, Ayoub Saei, Sarah Foulkes, Lizzie Stafford, Sile Johnson, Daniel G. Wootton, Christopher P. Conlon, Katie Jeffery, Philippa C. Matthews, John Frater, Alexandra S. Deeks, Andrew J. Pollard, Anthony Brown, Sarah L. Rowland-Jones, Juthathip Mongkolsapaya, Eleanor Barnes, Susan Hopkins, Victoria Hall, Christina Dold, Christopher J.A. Duncan, Alex Richter, Miles Carroll, Gavin Screaton, Thushan I. de Silva, Lance Turtle, Paul Klenerman, Susanna Dunachie, Hibatullah Abuelgasim, Emily Adland, Syed Adlou, Hossain Delowar Akther, Ahmed Alhussni, Mohammad Ali, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Martin Bayley, Helen Brown, Jeremy Chalk, Meera Chand, Anu Chawla, Senthil Chinnakannan, Joseph Cutteridge, Catherine de Lara, Lucy Denly, Ben Diffey, Stavros Dimitriadis, Thomas M. Drake, Timothy Donnison, Maeva Dupont, David Eyre, Alex Fairman, Siobhan Gardiner, Javier Gilbert-Jarmillo, Philip Goulder, Carl-Philipp Hackstein, Sophie Hambleton, Muzlifah Haniffa, Jenny Haworth, Jennifer Holmes, Emily Horner, Anni Jämsén, Chris Jones, Mwila Kasanyinga, Sinead Kelly, Rosemary Kirk, Michael L. Knight, Allan Lawrie, Lian Lee, Lauren Lett, Katy Lillie, Nicholas Lim, Hema Mehta, Alexander J. Mentzer, Denise O’Donnell, Ane Ogbe, Matthew Pace, Brendan A.I. Payne, Gareth Platt, Sonia Poolan, Nicholas Provine, Narayan Ramamurthy, Nichola Robinson, Leigh Romaniuk, Patpong Rongkard, Oliver L. Sampson, Beatrice Simmons, Jarmila S. Spegarova, Emily Stephenson, Kris Subramaniam, James Thaventhiran, Sarah Thomas, Simon Travis, Stephanie Tucker, Helena Turton, Adam Watson, Lisa Watson, Esme Weeks, Robert Wilson, Steven Wood, Rachel Wright, Huiyuan Xiao, Amira A.T. Zawia
Publikováno v:
CELL
Cell
Cell
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the UK to accelerate population coverage with a single dose. At this time, trial data was lacking, and we addressed this in a study of UK healthcare worke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3759990625e1d7316179914d2a3269e4
https://doi.org/10.1016/j.cell.2021.10.011
https://doi.org/10.1016/j.cell.2021.10.011
Autor:
Calli Dendrou, Kate Lynch, Fabiola Curion, Charlotte Rich-Griffin, Hing-Yuen Yeung, Nicholas Provine, Nicholas Ilott, Helen Ferry, Eve Fryer, Holm Uhlig, Roger W.G. Chapman, Satish Keshav, Paul Klenerman
Publikováno v:
Journal of Hepatology. 77:S602
This protocol is for the isolation of the epithelial cells (and associated immune cells within the epithelial layer) from frozen human intestinal pinch biopsies, for use in single-cell sequencing or flow cytometry experiments. This protocol is adapte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d7e331184d904bd0db2388dfbcca7e
https://doi.org/10.17504/protocols.io.bcb6isre
https://doi.org/10.17504/protocols.io.bcb6isre
This protocol is designed for the freezing, thawing, and processing of human intestinal pinch biopsies for isolation of live CD45+ leukocytes and downstream applications such as flow cytometry or single-cell RNA-sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49c4016a2d22c46a74428dd6e1fabfa
https://doi.org/10.17504/protocols.io.6nvhde6
https://doi.org/10.17504/protocols.io.6nvhde6
Autor:
Nicholas Provine, Alexander Badamchi-Zadeh, Christine Bricault, Pablo Penaloza-MacMaster, Rafael Larocca, Lily Parenteau, Stephen Blackmore, Erica Borducchi, Dan Barouch
Publikováno v:
The Journal of Immunology. 194:72.16-72.16
BACKGROUND: Recombinant adenovirus (Ad) vectors have recently garnered interest as vaccine platforms to elicit robust antibody (Ab) responses. In this study we seek to determine the timing of CD4 T cell help for the induction of these Ab responses. M
Adenovirus 5 vaccination elicits IL-27, which impairs CD4 and CD8 T cell functionality (VAC12P.1113)
Autor:
Rafael Larocca, Nicholas Provine, M. Iampietro, Erica Borducchi, Pablo Penaloza-MacMaster, Christine Bricault, Eryn Blass, Lily Parenteau, Stephen Blackmore, Kathryn Stephenson, Dan Barouch
Publikováno v:
The Journal of Immunology. 194:213.4-213.4
In pre-clinical studies Ad26 has shown increased protective efficacy compared to Ad5. We hypothesize this is due, in part, to differences in phenotype and function of the elicited CD4 and CD8 T cell responses. Thus, our goal is to elucidate the pheno
Autor:
Pablo Penaloza-MacMaster, Daniel Barber, E. Wherry, Nicholas Provine, Jeffrey E. Teigler, Lily Parenteau, Stephen Blackmore, Erica Borducchi, Rafael Larocca, Kathleen Yates, Hao Shen, W. Haining, Rami Sommerstein, Daniel Pinschewer, Rafi Ahmed, Dan Barouch
Publikováno v:
The Journal of Immunology. 194:74.9-74.9
CD4 T cells promote memory immune responses, but it is unclear whether vaccine-induced CD4 T cells contribute to immune protection. We interrogated if virus-specific CD4 T cells would protect mice against infection with chronic lymphocytic choriomeni
Ad5 but not Ad26 induces an IFN-γ+IL-10+ CD4+ T cell population following immunization (VAC12P.1023)
Publikováno v:
The Journal of Immunology. 192:206.12-206.12
Adenovirus-based vaccines have arisen as an attractive method to elicit robust cellular and humoral immune responses. Multiple vector serotypes have been developed, but the CD4+ regulatory T cell responses generated by these vectors have not previous