Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicholas Pasternack"'
Autor:
Marta Garcia-Montojo, Saeed Fathi, Cyrus Rastegar, Elena Rita Simula, Tara Doucet-O’Hare, Y. H. Hank Cheng, Rachel P. M. Abrams, Nicholas Pasternack, Nasir Malik, Muzna Bachani, Brianna Disanza, Dragan Maric, Myoung-Hwa Lee, Herui Wang, Ulisses Santamaria, Wenxue Li, Kevon Sampson, Juan Ramiro Lorenzo, Ignacio E. Sanchez, Alexandre Mezghrani, Yan Li, Leonardo Antonio Sechi, Sebastian Pineda, Myriam Heiman, Manolis Kellis, Joseph Steiner, Avindra Nath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 protein (ASRGL1) cleaves isoaspartates, which alter protein folding an
Externí odkaz:
https://doaj.org/article/3f8582a67a364758825325a7f9cb9801
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110147- (2024)
Summary: Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease with no cure. Human endogenous retroviruses (HERVs) have been implicated in its pathogenesis but their relevance to ALS is not fully understood. We examined
Externí odkaz:
https://doaj.org/article/ad737de41ccc44ca84dce6fe71068948
Autor:
Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3
Externí odkaz:
https://doaj.org/article/f4c24c167c97494e92ebdf24a5229496
Autor:
Wenxue Li, Darshan Pandya, Nicholas Pasternack, Marta Garcia-Montojo, Lisa Henderson, Christine A. Kozak, Avindra Nath
Publikováno v:
Neurotherapeutics. 19:1085-1101
The study of the role of retroviruses in amyotrophic lateral sclerosis (ALS) dates back to the 1960s shortly after transposable elements themselves were first discovered. It was quickly realized that in wild mice both horizontal and vertical transmis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2144fc25810263ff55ab044cc4144cd
https://doi.org/10.1007/s13311-022-01233-8
https://doi.org/10.1007/s13311-022-01233-8
Autor:
Myoung Hwa Lee, Daniel P Perl, Joseph Steiner, Nicholas Pasternack, Wenxue Li, Dragan Maric, Farinaz Safavi, Iren Horkayne-Szakaly, Robert Jones, Michelle N Stram, Joel T Moncur, Marco Hefti, Rebecca D Folkerth, Avindra Nath
Publikováno v:
Brain : a journal of neurology. 145(7)
The underlying mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to acute and long-term neurological manifestations remains obscure. We aimed to characterize the neuropathological changes in patients with coronavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1c2940fb6b0f679ef66f3f422f4e1c
https://pubmed.ncbi.nlm.nih.gov/36326831
https://pubmed.ncbi.nlm.nih.gov/36326831
Autor:
Ruth E. Siddorn, Katherine R. Brimblecombe, Emanuel F. Lopes, Nicholas Pasternack, Peter J. Magill, Richard Wade-Martins, Sarah Threlfell, Nora Bengoa-Vergniory, Natalie Connor-Robson, Natalie M. Doig, Bradley M. Roberts, Stephanie J. Cragg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be determined by plasma membrane GABA uptake transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb111576fd5377bcd50d1b23709f72f
https://orca.cardiff.ac.uk/id/eprint/142157/1/s41467-020-18247-5.pdf
https://orca.cardiff.ac.uk/id/eprint/142157/1/s41467-020-18247-5.pdf
