Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Nicholas P.J. Brindle"'
Publikováno v:
Clinical and Experimental Medicine
Septicaemia is an acute inflammatory reaction in the bloodstream to the presence of pathogen-associated molecular patterns. Whole blood stimulation assays capture endotoxin-induced formation of aggregates between platelets and leucocytes using flow c
Autor:
Despoina Giakomidi, Neil Bate, Eyad Issa, Hussein Farah, Nicholas P.J. Brindle, Mandeep Kang, Sultan Ahmed, Andrew J. Moss, Marlies Fischer
Publikováno v:
Molecular pharmaceutics. 15(9)
Angiopoietin-1 (Ang1) is a vascular protective ligand that acts through the receptor tyrosine kinase Tie2 to enhance endothelial survival and quiescence. In sepsis, diabetic retinopathy, and a range of other diseases, Ang2, an antagonist of Tie2, inc
Publikováno v:
Basic Science.
Introduction Angiopoietin-2 (Ang2) is a secreted ligand whose concentration is increased in several cardiovascular diseases, and which causes vascular inflammation, microvessel disintegration, cardiac fibrosis and myocardial damage. Ang2 binds the en
Autor:
Shikha Sharma, Julian E. Sale, Teonchit Nuamchit, Hiroshi Arakawa, Jean-Marie Buerstedde, Kathryn H. Steele, Nicholas P.J. Brindle
Publikováno v:
The Journal of Biological Chemistry
Background: The ligand angiopoietin2 contributes to vascular diseases. Results: A new directed evolution method was used to create a specific angiopoietin2-binding protein from a nonspecific angiopoietin receptor. Conclusion: The receptor binding spe
Autor:
Harprit Singh, Christopher S. Milner, Maria M. Aguilar Hernandez, Nisha Patel, Nicholas P.J. Brindle
Publikováno v:
Cellular Signalling. 21:1346-1350
The ability of cells to respond appropriately to changes in their environment requires integration and cross-talk between relevant signalling pathways. The vascular endothelial growth factor (VEGF) and angiopoietin families of ligands are key regulat
Publikováno v:
Microvascular Research. 77:187-191
Angiopoietin-1 (Ang1) has key roles in development and maintenance of the vascular system. The ligand is a potent inhibitor of vascular leakage and suppresses endothelial apoptosis and vessel regression. Ang1 was originally identified as a ligand for
Publikováno v:
Current Neurovascular Research. 5:236-245
Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) were originally identified as endothelial-specific ligands regulating key functions of the vasculature important in stroke. There is increasing evidence that these ligands also exert
Autor:
Hak-Zoo Kim, Jais Kavumkal, Gou Young Koh, Harprit Singh, Nicholas P.J. Brindle, Marie B. Marron, Tariq A. Tahir
Publikováno v:
Journal of Biological Chemistry. 282:30509-30517
Regulated ectodomain shedding followed by intramembrane proteolysis has recently been recognized as important in cell signaling and for degradation of several type I transmembrane proteins. The receptor-tyrosine kinase Tie1 is known to undergo ectodo
Autor:
Kathryn A. Gill, Nicholas P.J. Brindle
Publikováno v:
Biochemical and Biophysical Research Communications. 336:392-396
The factors controlling recruitment of endogenous and transplanted endothelial progenitor cells (EPC) to areas of neovascularization are largely unknown. In this study, we have examined the possibility that EPC migration and adhesion could be regulat
Autor:
Diane C. Darland, Nicholas P.J. Brindle, Amir Tadros, Benjamin J. Dunmore, Patricia A. D'Amore, Paul N. Morris, Douglas A. Marchuk
Publikováno v:
Journal of Molecular Medicine. 83:58-63
Tie2 is expressed predominantly in endothelial cells and is required for blood vessel formation and maintenance. A missense mutation resulting in an R to W substitution in the kinase domain of Tie2 co-segregates with an autosomal dominantly inherited