Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicholas P. van der Munnik"'
Publikováno v:
Journal of Chemical Theory and Computation. 14:2696-2704
Amyloid-β (Aβ) protein aggregates through a complex pathway to progress from monomers to soluble oligomers and ultimately insoluble fibrils. Because of the dynamic nature of aggregation, it has proven exceedingly difficult to determine the precise
Autor:
McCall Rogers, Nicholas P. van der Munnik, John Will Reed, Melissa A. Moss, Steven Zebulon Vance, Kayla M. Pate
Publikováno v:
CNS Neuroscience & Therapeutics. 23:135-144
SummaryAims Epidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid-β (Aβ) ol
Autor:
Kayla M. Pate, Venetia D. Lyles, Rahina Mahtab, Lemeisha Jones, Mihyun Lim, Shanee Mobley, Samuel E. Lohse, Vanessa M. Napumecheno, Mark J. Uline, Catherine J. Murphy, Deborah D. Soto-Ortega, Nisha Glassgow, Kaliah S. Jackson, Melissa A. Moss, Nicholas P. van der Munnik, Kelly A. Moore
Publikováno v:
Journal of Biological Engineering
Background Deposits of aggregated amyloid-β protein (Aβ) are a pathological hallmark of Alzheimer’s disease (AD). Thus, one therapeutic strategy is to eliminate these deposits by halting Aβ aggregation. While a variety of possible aggregation in
Autor:
Claudius Mundoma, Gaurav Ghag, Randi G. Reed, Melissa A. Moss, Nicholas P. van der Munnik, Lauren M. Wolf, Vijayaraghavan Rangachari
Publikováno v:
Protein engineering, designselection : PEDS. 29(5)
Granulins (Grns) are a family of small, cysteine-rich proteins that are generated upon proteolytic cleavage of their precursor, progranulin (Pgrn). All seven Grns (A-G) contain 12 conserved cysteines that form 6 intramolecular disulfide bonds, render
Publikováno v:
Biophysical Journal. 112:364a
Alzheimer's disease (AD) is the most common neurodegenerative disease. A mounting body of research implicates amyloid-β (Aβ) oligomers as an etiological factor in AD. However, the exact structure and stability of these species remains unclear. We h